Vol 8, No 4 (2017)
Review paper
Published online: 2018-02-24

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Erythroferrone — a new hormone regulating production of hepcidin

Edyta Knap, Beata Jakubowska-Solarska, Magdalena Nieśpiałowska
Hematologia 2017;8(4):265-270.


Iron is an essential bioelement for life, however both a deficiency and overload can lead to serious disorders in body function. Different proteins are involved in maintaining systemic iron homeostasis. Many of these have already been well-described, and some are commonly used markers for assessing iron metabolism. In 2014, a new protein was identified, erythroferrone, which suppresses hepcidin synthesis while increasing the availability of iron that is essential for erythropoiesis. The paper is therefore aimed at presenting current knowledge on the structure, function and the potential
uses of erythroferrone.

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