open access

Vol 4, No 4 (2013)
Review paper
Published online: 2014-02-06
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Pathogenesis of lymphoid malignancies

Emilia Białopiotrowicz, Krzysztof Warzocha, Przemysław Juszczyński
Hematologia 2013;4(4):321-332.

open access

Vol 4, No 4 (2013)
REVIEW ARTICLES
Published online: 2014-02-06

Abstract

Lymphocyte development is a complex and multistep process that leads to generation of a repertoire of cells endowed with specific receptors and capable of recognizing and responding to antigens. The B- (BCR) and T-cell (TCR) receptors are generated as a result of immunoglobulin or TCR gene re­arrangements that involve DNA double strand breaks. The DNA editing processes occurring in de­veloping lymphocytes predispose cells to primary translocations and oncogenic mutations, followed by additional aberrations accumulating in the background of these primary lesions. Arising typical, recurrent genetic abnormalities are a diagnostic feature of certain lymphoid malignancies. Genetic and epigenetic lesions accumulating within cells lead to deregulated signaling pathways and un­controlled cell proliferation, resistance to apoptosis and metabolic changes. Transformed cells retain some features of their normal counterparts, such as reliance on tonic BCR signaling and signals delivered by microenvironment. In the current manuscript, we provide a concise review of common pathogenic mechanisms in lymphoid tumors and their biological implications.

Abstract

Lymphocyte development is a complex and multistep process that leads to generation of a repertoire of cells endowed with specific receptors and capable of recognizing and responding to antigens. The B- (BCR) and T-cell (TCR) receptors are generated as a result of immunoglobulin or TCR gene re­arrangements that involve DNA double strand breaks. The DNA editing processes occurring in de­veloping lymphocytes predispose cells to primary translocations and oncogenic mutations, followed by additional aberrations accumulating in the background of these primary lesions. Arising typical, recurrent genetic abnormalities are a diagnostic feature of certain lymphoid malignancies. Genetic and epigenetic lesions accumulating within cells lead to deregulated signaling pathways and un­controlled cell proliferation, resistance to apoptosis and metabolic changes. Transformed cells retain some features of their normal counterparts, such as reliance on tonic BCR signaling and signals delivered by microenvironment. In the current manuscript, we provide a concise review of common pathogenic mechanisms in lymphoid tumors and their biological implications.

Get Citation

Keywords

lymphomas, pathogenesis, genetic aberrations, microenvironment Hematologia 2013;

About this article
Title

Pathogenesis of lymphoid malignancies

Journal

Hematology in Clinical Practice

Issue

Vol 4, No 4 (2013)

Article type

Review paper

Pages

321-332

Published online

2014-02-06

Bibliographic record

Hematologia 2013;4(4):321-332.

Keywords

lymphomas
pathogenesis
genetic aberrations
microenvironment Hematologia 2013

Authors

Emilia Białopiotrowicz
Krzysztof Warzocha
Przemysław Juszczyński

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