Vol 10, No 1 (2019)
Review paper
Published online: 2019-06-19
The importance of neprilysin (CD10) in hematooncology
DOI: 10.5603/Hem.2019.0013
Hematologia 2019;10(1):19-28.
Abstract
CD10 is an extracellular protein with enzymatic activity. Its substrates are various substances with the properties of signal particles. CD10 also has in itself the propriety of transmitting signals via the membrane, and affecting various intracellular signal transduction pathways, through interaction with numerous protein complexes. CD10 expression is observed in many normal tissues as well as in selected tumors. It is therefore particularly important in histopathological differential diagnosis. The following article presents the structure, location and functions of the CD10. The effect of CD10 expression on the clinical course and prognosis in hematological and non-haematological malignancies is also described.
Keywords: CD10neprilysinimmunohistochemical expressionhematooncology
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