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Vol 8, No 3 (2017)
Review paper
Published online: 2017-11-23

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Diagnosis and treatment of patients with mature T-cell and NK-cell neoplasms

Krzysztof Warzocha1, Bartosz Puła1
DOI: 10.5603/Hem.2017.0022
Hematologia 2017;8(3):177-196.

Abstract

Mature T-cell and NK-cell neoplasms comprise a heterogenous group of diseases of lymphoid origin. Approximately 10–15% of the diagnosed lymphomas make up to this category. These neoplasms are characterized by differentiated clinical and pathomorphological traits, frequent extranodal mani¬festations and poor outcome. Given their relatively rare occurrence, high heterogeneity and lack of randomized clinical trials, work out of unified recommendations is difficult. Nevertheless, chemo¬therapy and hematopoietic stem cell transplantation seem to be effective in up-front and relapsed and refractory setting. In this publication we discuss the guidelines of diagnosis and treatment of this heterogenous malignancy group.

Keywords: mature T-cell and NK-cell neoplasmschemotherapyhematopoietic stem cell transplantationprognosisdiagnostics

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