Myeloproliferative neoplasms and myelodysplastic syndromes — advances in diagnosis and therapy
Abstract
During recent years there has been a significant progress in the diagnosis and therapy of myeloproliferative neoplasms and myelodysplastic syndromes. The application of novel sequencing techniques has led to the discovery of multiple recurrently mutated genes that has largely improved our understanding of the biological complexity of these malignancies. Most importantly, these new findings on molecular pathogenesis have resulted in the development of effective targeted therapies as well as construction of new prognostic indexes that facilitate patients’ assignment to proper type of treatment.
Keywords: polycythemia veraessential thrombocythemiaprimary myelofibrosismyelodysplastic syndromesprognostic scalestherapy