Molecular oncogenic defects in subtypes of diffuse large B-cell lymphoma

Abstract

Diffuse large B-cell lymphoma (DLBCL), which is characterized by the uncontrolled growth of mature, peripheral B-cells, constitutes a group of heterogeneous diseases in terms of morphological, biological and clinical features. The classification of DLBCL based on the location of the tumor, his­topathology, immunophenotype, etiology, and similarity to other diseases of the B lymphocytes. This review presents an update on the molecular abnormalities identified in the major subtypes of the disease, e.g. germinal center B-cell and activated B-cell, and their importance in context of the clinical course of disease.