Tom 2, Supl. B (2011)
OPISY PRZYPADKÓW
Opublikowany online: 2012-02-28
Problemy terapeutyczne chorego ze współistnieniem przewlekłej białaczki szpikowej i szpiczaka plazmocytowego
Ilona Seferyńska, Monika Prochorec-Sobieszek, Krzysztof Warzocha
Tom 2, Supl. B (2011)
OPISY PRZYPADKÓW
Opublikowany online: 2012-02-28
Streszczenie
Neoplastic disorders derived from lymphoid or hematopoietic lineages have been hitherto rarely described in cases where they jointly occur. Here a patient with chronic myeloid leukemia
(CML) and plasma cell myeloma (PCM) is presented with proliferation of leukemia cells being dominant at presentation. Following several months of treatment with tyrosine kinase inhibitors, suppression of the leukemic clone was achieved but with a concomitant proliferation of
bone marrow plasma cells. Subsequent chemotherapy resulted in partial remission of PCM however proliferation of leukemia cells was again noted. Due to this treatment regime being
ineffective it was therefore decided to replace any further treatment with interferon alpha which is recognized to be active against PCM and CML cells. Minimal doses of nilotynib may also be
given if adequate hematological tolerance were to be observed.
Streszczenie
Neoplastic disorders derived from lymphoid or hematopoietic lineages have been hitherto rarely described in cases where they jointly occur. Here a patient with chronic myeloid leukemia
(CML) and plasma cell myeloma (PCM) is presented with proliferation of leukemia cells being dominant at presentation. Following several months of treatment with tyrosine kinase inhibitors, suppression of the leukemic clone was achieved but with a concomitant proliferation of
bone marrow plasma cells. Subsequent chemotherapy resulted in partial remission of PCM however proliferation of leukemia cells was again noted. Due to this treatment regime being
ineffective it was therefore decided to replace any further treatment with interferon alpha which is recognized to be active against PCM and CML cells. Minimal doses of nilotynib may also be
given if adequate hematological tolerance were to be observed.
Słowa kluczowe
przewlekła białaczka szpikowa; szpiczak plazmocytowy; leczenie
Tytuł
Problemy terapeutyczne chorego ze współistnieniem przewlekłej białaczki szpikowej i szpiczaka plazmocytowego
Czasopismo
Hematologia
Numer
Tom 2, Supl. B (2011)
Strony
28-32
Data publikacji on-line
2012-02-28
Słowa kluczowe
przewlekła białaczka szpikowa
szpiczak plazmocytowy
leczenie
Autorzy
Ilona Seferyńska
Monika Prochorec-Sobieszek
Krzysztof Warzocha
Informacje o artykule