Vol 1, No 4 (2010)
Review paper
Published online: 2010-11-24
Prophylaxis and treatment of the central nervous system involvement in lymphoid malignancies
Hematologia 2010;1(4):352-358.
Abstract
Lymphoid malignancies may be accompanied by primary or secondary involvement of central
nervous system (CNS). The risk is particularly high in course acute lymphoblastic leukemia
(ALL)/lymphoblastic lymphoma (LBL), Burkitt lymphoma (BL), selected patients with diffuse
large B cell lymphoma (DLBCL) and unclassifiable large B cell lymphoma with features
between DLBCL and BL. The diagnosis of CNS involvement implicates the need for intensive
treatment including intrathecal chemotherapy as well as intravenous infusion of high doses of
cytostatics crossing the blood-brain barrier. As the prognosis of patients with CNS relapse is
poor, appropriate prophylaxis is required. In this paper we present recommendations of the
Polish Adult Leukemia Group (PALG) and the Polish Lymphoma Research Group (PLRG).
Hematologia 2010; 1, 4: 352-358
Hematologia 2010; 1, 4: 352-358
Keywords: acute lymphoblastic leukemiadiffuse large B cell lymphomacentral nervous systemprophylaxistreatment
