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Vol 93, No 3 (2022)
Research paper
Published online: 2021-04-23
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Magnetic resonance-guided high-intensity ultrasound (MR-HIFU) in the treatment of symptomatic uterine fibroids — five-year experience

Tomasz Lozinski1, Justyna Filipowska12, Magdalena Pyka1, Monika Baczkowska3, Michal Ciebiera3
DOI: 10.5603/GP.a2021.0098
·
Pubmed: 33914323
·
Ginekol Pol 2022;93(3):185-194.
Affiliations
  1. Department of Obstetrics and Gynaecology Pro-Familia Hospital, Rzeszow, Poland
  2. Electroradiology Department, Jagiellonian University Medical College, Cracow, Poland
  3. Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, Warsaw, Poland

open access

Vol 93, No 3 (2022)
ORIGINAL PAPERS Gynecology
Published online: 2021-04-23

Abstract

Objectives: Uterine fibroids (UF) are the most common benign tumors of the female reproductive organ. It is crucial to recognize that the appropriate treatment of UFs requires an individualized approach. The present paper aimed at the presentation of the five-year experience of our center in the treatment of UFs with the use of magnetic resonance-guided high-intensity ultrasound (MR-HIFU) therapy. Material and methods: The study enrolled a total of 1284 patients with symptomatic UFs. The Sonalleve MR-HIFU system (Philips Ingenia 3.0T System) was used for magnetic resonance imaging (MRI) qualification and treatment. Results: The group of patients qualified for thermal ablation included 356 (28%) women. No significant differences were observed between the group undergoing thermal ablation and patients who were disqualified. A complete procedure was performed in 22.6% of patients who presented at the center. Non-perfused volume (NPV) is one of the most important parameters assessed during MR-HIFU procedures. The mean NPV value in the present study was 71%. The average UF volumes decreased by 27% at three-month follow-up ultrasound, by 34% after six months and by 39% as shown by MRI measurements performed 6 months post-treatment. Conclusions: According to our data, MR-HIFU therapy is associated with good clinical outcomes in patients with symptomatic UFs. The method facilitates a marked symptom reduction and, in many cases, diminishing tumor volume. The presented five-year outcomes as regards our experience in the MR-HIFU therapy of patients with symptomatic UFs indicate that the method offers an attractive alternative to the traditional methods of UF treatment in selected cases.

Abstract

Objectives: Uterine fibroids (UF) are the most common benign tumors of the female reproductive organ. It is crucial to recognize that the appropriate treatment of UFs requires an individualized approach. The present paper aimed at the presentation of the five-year experience of our center in the treatment of UFs with the use of magnetic resonance-guided high-intensity ultrasound (MR-HIFU) therapy. Material and methods: The study enrolled a total of 1284 patients with symptomatic UFs. The Sonalleve MR-HIFU system (Philips Ingenia 3.0T System) was used for magnetic resonance imaging (MRI) qualification and treatment. Results: The group of patients qualified for thermal ablation included 356 (28%) women. No significant differences were observed between the group undergoing thermal ablation and patients who were disqualified. A complete procedure was performed in 22.6% of patients who presented at the center. Non-perfused volume (NPV) is one of the most important parameters assessed during MR-HIFU procedures. The mean NPV value in the present study was 71%. The average UF volumes decreased by 27% at three-month follow-up ultrasound, by 34% after six months and by 39% as shown by MRI measurements performed 6 months post-treatment. Conclusions: According to our data, MR-HIFU therapy is associated with good clinical outcomes in patients with symptomatic UFs. The method facilitates a marked symptom reduction and, in many cases, diminishing tumor volume. The presented five-year outcomes as regards our experience in the MR-HIFU therapy of patients with symptomatic UFs indicate that the method offers an attractive alternative to the traditional methods of UF treatment in selected cases.

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Keywords

uterine fibroid; leiomyoma; non-invasive; magnetic resonance imaging; magnetic resonance-guided high-intensity ultrasound; MR-HIFU

About this article
Title

Magnetic resonance-guided high-intensity ultrasound (MR-HIFU) in the treatment of symptomatic uterine fibroids — five-year experience

Journal

Ginekologia Polska

Issue

Vol 93, No 3 (2022)

Article type

Research paper

Pages

185-194

Published online

2021-04-23

Page views

6350

Article views/downloads

1488

DOI

10.5603/GP.a2021.0098

Pubmed

33914323

Bibliographic record

Ginekol Pol 2022;93(3):185-194.

Keywords

uterine fibroid
leiomyoma
non-invasive
magnetic resonance imaging
magnetic resonance-guided high-intensity ultrasound
MR-HIFU

Authors

Tomasz Lozinski
Justyna Filipowska
Magdalena Pyka
Monika Baczkowska
Michal Ciebiera

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