open access

Vol 92, No 1 (2021)
Research paper
Published online: 2021-01-29
Get Citation

The influence of hepatitis B virus (HBV) or hepatitis C virus (HCV) infections on the pregnancy course

Julita Nikolajuk-Stasiuk1, Tadeusz W. Lapinski1
·
Pubmed: 33576489
·
Ginekol Pol 2021;92(1):30-34.
Affiliations
  1. Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Poland, Poland

open access

Vol 92, No 1 (2021)
ORIGINAL PAPERS Obstetrics
Published online: 2021-01-29

Abstract

Objectives: The incidence of HBV infections among the pregnant in Europe falls within the range of 1–7%, whereas it is
1.7–4.3% for HCV.
The aim was to assess the course of pregnancy among women infected with HBV or HCV, and the condition of neonates
in the fifth minute after the birth.
Material and methods: The study included 157 pregnant individuals infected with HBV, 53 infected with HCV, and
330 healthy pregnant women. None of the women infected with HBV and HCV as well as from the control group were
infected with HIV, and none of them took intoxicants.
Results: Weight of neonates delivered by healthy women was higher as compared with children born by women infected
with HBV or HCV (3.517 vs 3.347 and 3.366). The Apgar score of neonates delivered by women with HBV and HCV infections
was lower as compared with the children born by healthy women (9.4 vs 9.3 vs 9.7; p < 0.05). Premature births occurred
more often in HBV and HCV-infected women than in the control group (14.6% and 24.5% vs 6.96%; p < 0.05). Miscarriages
were significantly more common among the patients with HCV infections as compared with the patients who were healthy
(9.4% vs 1.8%; p < 0.05). In comparison with the healthy individuals, this group of patients experienced pruritus (10.5% vs
4.2%; p < 0.05), oedemas (9.4% vs 2.4%; p < 0.05), and hypertension (9.4% vs 1.5%; p < 0.05) more often.
An increase in HBV loads was observed between the 6th and 28th–32nd week of pregnancy among the infected with HBV,
and then, a decrease was observed in the 6th months after the delivery.
Conclusions: The women infected with HBV without HBsAg (–) and the infected with HCV are subject to common incidence
of premature births. Women infected with HCV often experience oedemas, hypertension, and pruritus.

Abstract

Objectives: The incidence of HBV infections among the pregnant in Europe falls within the range of 1–7%, whereas it is
1.7–4.3% for HCV.
The aim was to assess the course of pregnancy among women infected with HBV or HCV, and the condition of neonates
in the fifth minute after the birth.
Material and methods: The study included 157 pregnant individuals infected with HBV, 53 infected with HCV, and
330 healthy pregnant women. None of the women infected with HBV and HCV as well as from the control group were
infected with HIV, and none of them took intoxicants.
Results: Weight of neonates delivered by healthy women was higher as compared with children born by women infected
with HBV or HCV (3.517 vs 3.347 and 3.366). The Apgar score of neonates delivered by women with HBV and HCV infections
was lower as compared with the children born by healthy women (9.4 vs 9.3 vs 9.7; p < 0.05). Premature births occurred
more often in HBV and HCV-infected women than in the control group (14.6% and 24.5% vs 6.96%; p < 0.05). Miscarriages
were significantly more common among the patients with HCV infections as compared with the patients who were healthy
(9.4% vs 1.8%; p < 0.05). In comparison with the healthy individuals, this group of patients experienced pruritus (10.5% vs
4.2%; p < 0.05), oedemas (9.4% vs 2.4%; p < 0.05), and hypertension (9.4% vs 1.5%; p < 0.05) more often.
An increase in HBV loads was observed between the 6th and 28th–32nd week of pregnancy among the infected with HBV,
and then, a decrease was observed in the 6th months after the delivery.
Conclusions: The women infected with HBV without HBsAg (–) and the infected with HCV are subject to common incidence
of premature births. Women infected with HCV often experience oedemas, hypertension, and pruritus.

Get Citation

Keywords

HBV or HCV infection in pregnancy; childbirth

About this article
Title

The influence of hepatitis B virus (HBV) or hepatitis C virus (HCV) infections on the pregnancy course

Journal

Ginekologia Polska

Issue

Vol 92, No 1 (2021)

Article type

Research paper

Pages

30-34

Published online

2021-01-29

Page views

1000

Article views/downloads

867

DOI

10.5603/GP.a2020.0139

Pubmed

33576489

Bibliographic record

Ginekol Pol 2021;92(1):30-34.

Keywords

HBV or HCV infection in pregnancy
childbirth

Authors

Julita Nikolajuk-Stasiuk
Tadeusz W. Lapinski

References (15)
  1. Jonas MM. Hepatitis B and pregnancy: an underestimated issue. Liver Int. 2009; 29 Suppl 1: 133–139.
  2. Komatsu H, Inui A, Komatsu H, et al. [Long-term history of chronic hepatitis B virus infection in children]. Nihon Rinsho. 2004; 62 Suppl 8(6): 303–308.
  3. European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, European Association for the Study of the Liver. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol. 2017; 67(2): 370–398.
  4. Patton H, Tran TT. Management of hepatitis B during pregnancy. Nat Rev Gastroenterol Hepatol. 2014; 11(7): 402–409.
  5. Cui AM, Cheng XY, Shao JG, et al. Maternal hepatitis B virus carrier status and pregnancy outcomes: a prospective cohort study. BMC Pregnancy Childbirth. 2016; 16: 87.
  6. Ayoub WS, Cohen E. Hepatitis B Management in the Pregnant Patient: An Update. J Clin Transl Hepatol. 2016; 4(3): 241–247.
  7. Floreani A. Hepatitis C and pregnancy. World J Gastroenterol. 2013; 19(40): 6714–6720.
  8. Gowda C, Kennedy S, Glover C, et al. Enhanced identification of maternal hepatitis C virus infection using existing public health surveillance systems. Paediatr Perinat Epidemiol. 2018; 32(4): 401–410.
  9. Kushner T, Cohen J, Tien PC, et al. Evaluating Women's Preferences for Hepatitis C Treatment During Pregnancy. Hepatol Commun. 2018; 2(11): 1306–1310.
  10. Safir A, Levy A, Sikuler E, et al. Maternal hepatitis B virus or hepatitis C virus carrier status as an independent risk factor for adverse perinatal outcome. Liver Int. 2010; 30(5): 765–770.
  11. He Q, Song X, Huang Y, et al. Dexamethasone Stimulates Hepatitis B Virus (HBV) Replication Through Autophagy. Med Sci Monit. 2018; 24: 4617–4624.
  12. Shimizu I, Kohno N, Tamaki K, et al. Female hepatology: favorable role of estrogen in chronic liver disease with hepatitis B virus infection. World J Gastroenterol. 2007; 13(32): 4295–4305.
  13. Söderström A, Norkrans G, Lindh M. Hepatitis B virus DNA during pregnancy and post partum: aspects on vertical transmission. Scand J Infect Dis. 2003; 35(11-12): 814–819.
  14. Yang YB, Li XM, Shi ZJ, et al. Pregnant woman with fulminant hepatic failure caused by hepatitis B virus infection: a case report. World J Gastroenterol. 2004; 10(15): 2305–2306.
  15. ter Borg MJ, Leemans WF, de Man RA, et al. Exacerbation of chronic hepatitis B infection after delivery. J Viral Hepat. 2008; 15(1): 37–41.

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl