Vol 91, No 9 (2020)
Research paper
Published online: 2020-09-23

open access

Page views 1852
Article views/downloads 1105
Get Citation

Connect on Social Media

Connect on Social Media

Are neutrophil to lymphocyte ratio and platelet to lymphocyte ratio clinically useful for the prediction of early pregnancy loss?

Süleyman Cemil Oğlak1, Mustafa Fırat Aydın1
Pubmed: 33030732
Ginekol Pol 2020;91(9):524-527.

Abstract

Objectives: Red cell distribution width (RDW), mean platelet volume (MPV), plateletcrit (PCT), platelet distribution width (PDW), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) have all been identified as systemic inflammatory markers. The aim of this study to investigate whether the use of systemic inflammatory markers can predict early pregnancy loss.
Material and methods: A total of 137 patients with early pregnancy loss was compared with 148 participants in the control group who had given birth at term. In the study group, CBC values were included in the study at the time of referral to the hospital for routine follow-up, while patients did not experience early pregnancy loss. In the control group, CBC values of the patient before the seventh week of pregnancy were included in the study.
Results: There was no significant difference between the two groups in terms of RDW, MPV, PCT and PDW values. The NLR and PLR values were significantly higher in the early pregnancy loss group than the control group (p < 0.05).
Conclusion: Our findings suggest that high NLR and PLR values are potent markers for the prediction of early pregnancy loss.

Article available in PDF format

View PDF Download PDF file

References

  1. American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology. ACOG Practice Bulletin No. 200: Early Pregnancy Loss. Obstet Gynecol. 2018; 132(5): e197–e207.
  2. Sapra KJ, Buck Louis GM, Sundaram R, et al. Signs and symptoms associated with early pregnancy loss: findings from a population-based preconception cohort. Hum Reprod. 2016; 31(4): 887–896.
  3. Sapra KJ, Joseph KS, Galea S, et al. Signs and symptoms associated with early pregnancy loss: findings from a population-based preconception cohort. Hum Reprod. 2016; 31(4): 887–896.
  4. Pinar MH, Gibbins K, He M, et al. Early Pregnancy Losses: Review of Nomenclature, Histopathology, and Possible Etiologies. Fetal Pediatr Pathol. 2018; 37(3): 191–209.
  5. Christiansen OB, Nielsen HS, Kolte AM. Inflammation and miscarriage. Semin Fetal Neonatal Med. 2006; 11(5): 302–308.
  6. Kalagiri RR, Carder T, Choudhury S, et al. Inflammation in Complicated Pregnancy and Its Outcome. Am J Perinatol. 2016; 33(14): 1337–1356.
  7. Calleja-Agius J, Jauniaux E, Pizzey AR, et al. Investigation of systemic inflammatory response in first trimester pregnancy failure. Hum Reprod. 2012; 27(2): 349–357.
  8. Tang J, Gao X, Zhi M, et al. Plateletcrit: a sensitive biomarker for evaluating disease activity in Crohn's disease with low hs-CRP. J Dig Dis. 2015; 16(3): 118–124.
  9. Wang J, Zhu QW, Cheng XY, et al. Assessment efficacy of neutrophil-lymphocyte ratio and monocyte-lymphocyte ratio in preeclampsia. J Reprod Immunol. 2019; 132: 29–34.
  10. Challis JR, Lockwood CJ, Myatt L, et al. Inflammation and pregnancy. Reprod Sci. 2009; 16(2): 206–215.
  11. Nadeau-Vallée M, Obari D, Palacios J, et al. Sterile inflammation and pregnancy complications: a review. Reproduction. 2016; 152(6): R277–R292.
  12. O'Hern Perfetto C, Fan X, Dahl S, et al. Expression of interleukin-22 in decidua of patients with early pregnancy and unexplained recurrent pregnancy loss. J Assist Reprod Genet. 2015; 32(6): 977–984.
  13. Sacerdoti F, Amaral MM, Aisemberg J, et al. Involvement of hypoxia and inflammation in early pregnancy loss mediated by Shiga toxin type 2. Placenta. 2015; 36(6): 674–680.
  14. Ku CW, Allen JC, Malforta R, et al. How can we better predict the risk of spontaneous miscarriage among women experiencing threatened miscarriage? Gynecol Endocrinol. 2015; 31(8): 647–51.
  15. Kim MA, Han GH, Kwon JY, et al. Clinical significance of platelet-to-lymphocyte ratio in women with preeclampsia. Am J Reprod Immunol. 2018; 80(1): e12973.
  16. Wada H, Dohi T, Miyauchi K, et al. Mean platelet volume and long-term cardiovascular outcomes in patients with stable coronary artery disease. Atherosclerosis. 2018; 277: 108–112.
  17. Wincup C, Parnell C, Cleanthous S, et al. Red cell distribution width correlates with fatigue levels in a diverse group of patients with systemic lupus erythematosus irrespective of anaemia status. Clin Exp Rheumatol. 2019; 37(5): 852–54.
  18. Jenne C, Kubes P. Platelets in inflammation and infection. Platelets. 2015; 26(4): 286–292.
  19. Karateke A, Kurt RK, Baloğlu A. Relation of platelet distribution width (PDW) and platelet crit (PCT) to preeclampsia. Ginekol Pol. 2015; 86(5): 372–375.
  20. Aynıoglu O, Isık H, Sahbaz A, et al. Can Plateletcrit be a Marker for Recurrent Pregnancy Loss? Clin Appl Thromb Hemost. 2016; 22(5): 447–452.
  21. Yao C, Liu X, Tang Ze. Prognostic role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio for hospital mortality in patients with AECOPD. Int J Chron Obstruct Pulmon Dis. 2017; 12: 2285–2290.
  22. Gezer C, Ekin A, Ertas IE, et al. High first-trimester neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios are indicators for early diagnosis of preeclampsia. Ginekol Pol. 2016; 87(6): 431–435.
  23. Yilmaz H, Celik HT, Namuslu M, et al. Benefits of the neutrophil-to-lymphocyte ratio for the prediction of gestational diabetes mellitus in pregnant women. Exp Clin Endocrinol Diabetes. 2014; 122(1): 39–43.
  24. Kirbas A, Biberoglu E, Daglar K, et al. Neutrophil-to-lymphocyte ratio as a diagnostic marker of intrahepatic cholestasis of pregnancy. Eur J Obstet Gynecol Reprod Biol. 2014; 180: 12–15.
  25. Christoforaki V, Zafeiriou Z, Daskalakis G, et al. First trimester neutrophil to lymphocyte ratio (NLR) and pregnancy outcome. J Obstet Gynaecol. 2020; 40(1): 59–64.