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A comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrateresistant polycystic ovary syndrome — a retrospective study
Affiliations- Department of Gynecology and Obstetrics, Health Sciences University, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey
- Department of Gynecology and Obstetrics, Dicle University, Diyarbakır, Turkey
- Department of Gynecology and Obstetrics, Memorial Hospital, Diyarbakir, Turkey
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Abstract
Objectives: The aim of this study was to compare a combination treatment with CC plus letrozole versus gonadotropins
in CC-resistant polycystic ovary syndrome (PCOS) patients with regard to ovulation and clinical pregnancy rate.
Material and methods: One hundred sixteen CC-resistant infertile PCOS patients were evaluated retrospectively. The patients
were divided into two groups. Group 1 (n = 73) received CC plus letrozole, and Group 2 (n = 43) received gonadotropins.
Results: The ovulation rate in Group 1 was 65/73 (89%), the pregnancy rate was 13/73 (18%), the twin foetuses rate was
1/73 (1.3%) and the miscarriage rate was 2/73 (2.7%). In Group 2, the ovulation rate was 41/43 (95%), and the pregnancy
rate was 8/43 (19%) the rate of the twin foetuses was 1/43 (2.3%) and the miscarriage rate was 1/43 (2.3%). There was no
statistically significant difference in the ovulation (p = 0.25), pregnancy (p = 0.91), twin foetuses (p = 0.89) and miscarriage
p = 0.89) rates between two groups.
Conclusions: This new drug combination suggests that it may be a lower cost, lower risk alternative treatment that increases
the rate of ovulation. Larger randomized clinical trials are needed to provide information on live birth rates of this
combination.
Abstract
Objectives: The aim of this study was to compare a combination treatment with CC plus letrozole versus gonadotropins
in CC-resistant polycystic ovary syndrome (PCOS) patients with regard to ovulation and clinical pregnancy rate.
Material and methods: One hundred sixteen CC-resistant infertile PCOS patients were evaluated retrospectively. The patients
were divided into two groups. Group 1 (n = 73) received CC plus letrozole, and Group 2 (n = 43) received gonadotropins.
Results: The ovulation rate in Group 1 was 65/73 (89%), the pregnancy rate was 13/73 (18%), the twin foetuses rate was
1/73 (1.3%) and the miscarriage rate was 2/73 (2.7%). In Group 2, the ovulation rate was 41/43 (95%), and the pregnancy
rate was 8/43 (19%) the rate of the twin foetuses was 1/43 (2.3%) and the miscarriage rate was 1/43 (2.3%). There was no
statistically significant difference in the ovulation (p = 0.25), pregnancy (p = 0.91), twin foetuses (p = 0.89) and miscarriage
p = 0.89) rates between two groups.
Conclusions: This new drug combination suggests that it may be a lower cost, lower risk alternative treatment that increases
the rate of ovulation. Larger randomized clinical trials are needed to provide information on live birth rates of this
combination.
Keywords
polycystic ovary syndrome; gonadotropins; clomiphene resistance; letrozole; ovulation induction
About this articleTitle
A comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrateresistant polycystic ovary syndrome — a retrospective study
Journal
Issue
Article type
Research paper
Pages
185-188
Published online
2020-03-31
Page views
1928
Article views/downloads
2645
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(4):185-188.
Keywords
polycystic ovary syndrome
gonadotropins
clomiphene resistance
letrozole
ovulation induction
Authors
Serhat Ege
Muhammed Hanifi Bademkıran
Nurullah Peker
Ali Emre Tahaoğlu
Fatma Nur Hançer Çaça
Serap Mutlu Özçelik
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