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ORIGINAL PAPERS Gynecology
Published online: 2020-05-05
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The impact of concurrent HPV infections on the presentation of high grade cervical intraepithelial lesions

Emine Ozturk, Onur Ince, İbrahim Karaca, Gokhan Demirayak, Cihan Comba, Ismail Alay, Volkan Sakir Erdogan, Suna Yıldırım Karaca, Isa Aykut Ozdemir
DOI: 10.5603/GP.a2020.0002
·
Pubmed: 32374017

open access

Ahead of Print
ORIGINAL PAPERS Gynecology
Published online: 2020-05-05

Abstract

Objectives: We investigate how concurrent high-risk (hr) HPV (human papillomavirus) genotypes affect CIN2-3 risk and evaluate the relationship of different genotype combinations with cervical epithelial lesions. Material and methods: This study included HPV positive patients between the ages of 30 and 60 who underwent liquid-based cervical smears and HPV screening through community-based, cervical cancer screening programs between June 2015 and June 2017. The impact of the increase in hrHPV types was calculated by estimating how it changed the odds ratio of CIN2-3 risk. Results: The rate of multiple concurrent HPV infections was 48.7% in the CIN2-3 group and 58.4% in the CIN1 group. Among patients in the CIN2-3 and CIN1 groups, the most common HPV coinfection was respectively HPV 16+31 and HPV 16+51. The HPV 51 ratio in CIN1 patients was 28.9% and the HPV 51 ratio in the CIN2-3 patient was 6.6%. With every increase in the number of hrHPV infection types, the frequency of CIN2-3 decreased [OR: 0.72, 95% CI: 0.54-0.95]. For all hrHPV combinations, the addition of HPV 16 was associated with a higher risk of CIN2-3. Conclusions: An increase in number of hrHPV types is associated with lower CIN2-3 risk. Further cohort studies with larger samples are needed to clarify this relationship. The available evidence suggests that HPV 16 genotype plays an important role in patients with high-grade cervical lesions and has a negative impact on the cervix in concurrent multiple HPV infections.

Abstract

Objectives: We investigate how concurrent high-risk (hr) HPV (human papillomavirus) genotypes affect CIN2-3 risk and evaluate the relationship of different genotype combinations with cervical epithelial lesions. Material and methods: This study included HPV positive patients between the ages of 30 and 60 who underwent liquid-based cervical smears and HPV screening through community-based, cervical cancer screening programs between June 2015 and June 2017. The impact of the increase in hrHPV types was calculated by estimating how it changed the odds ratio of CIN2-3 risk. Results: The rate of multiple concurrent HPV infections was 48.7% in the CIN2-3 group and 58.4% in the CIN1 group. Among patients in the CIN2-3 and CIN1 groups, the most common HPV coinfection was respectively HPV 16+31 and HPV 16+51. The HPV 51 ratio in CIN1 patients was 28.9% and the HPV 51 ratio in the CIN2-3 patient was 6.6%. With every increase in the number of hrHPV infection types, the frequency of CIN2-3 decreased [OR: 0.72, 95% CI: 0.54-0.95]. For all hrHPV combinations, the addition of HPV 16 was associated with a higher risk of CIN2-3. Conclusions: An increase in number of hrHPV types is associated with lower CIN2-3 risk. Further cohort studies with larger samples are needed to clarify this relationship. The available evidence suggests that HPV 16 genotype plays an important role in patients with high-grade cervical lesions and has a negative impact on the cervix in concurrent multiple HPV infections.

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Keywords

Human Papilloma Vırus, coinfection, cervical intraepithelial lesions

About this article
Title

The impact of concurrent HPV infections on the presentation of high grade cervical intraepithelial lesions

Journal

Ginekologia Polska

Issue

Ahead of Print

Published online

2020-05-05

DOI

10.5603/GP.a2020.0002

Pubmed

32374017

Keywords

Human Papilloma Vırus
coinfection
cervical intraepithelial lesions

Authors

Emine Ozturk
Onur Ince
İbrahim Karaca
Gokhan Demirayak
Cihan Comba
Ismail Alay
Volkan Sakir Erdogan
Suna Yıldırım Karaca
Isa Aykut Ozdemir

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