open access

Vol 91, No 12 (2020)
Research paper
Published online: 2020-12-31
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Comparison of Misoprostol versus Dinoprostone for delivery induction among pregnant women without concomitant disease

Teresa Gornisiewicz, Katarzyna Kusmierska-Urban, Hubert Huras, Aleksander Galas
DOI: 10.5603/GP.2020.0119
·
Pubmed: 33447991
·
Ginekol Pol 2020;91(12):726-732.

open access

Vol 91, No 12 (2020)
ORIGINAL PAPERS Obstetrics
Published online: 2020-12-31

Abstract

Objectives: Induction of labour is a part of an active prenatal care nowadays and the ideal method of that procedure still
remains to be identified. The purpose of this study was to evaluate effectiveness of misoprostol vaginal insert as compared
to dinoprostone gel for delivery induction in pregnant women without any comorbidities.
Material and methods: It was a retrospective cohort study of 240 pregnant women. The primary study outcome was
successful delivery. Other analysed parameters included time to delivery of a baby, time to the beginning of the first stage
of labour, time to vaginal delivery, and duration of all delivery stages. We compared both methods regarding maternal
complications during and after delivery. We also reviewed neonatal outcomes such as birth weight, birth length and
1-minute Apgar scores.
Results: The patients’ basic characteristics were similar regarding their age, gravidity, parity, height, weight and Bishop
score. Time to any delivery and to the onset of a labour in the misoprostol group versus in the dinoprostone group was
14.5 vs 35.6 h (p < 0.001) and 9.9 h vs 25.3 h (p < 0.001) respectively. The chance of the beginning of labour and the baby’s
delivery over time has been observed to be approximately two times higher for misoprostol as compared to dinoprostone.
Conclusions: Our study showed that using misoprostol vaginal insert in comparison to dinoprostone seems to shorten the
time to beginning of the first stage of labour as well as the time to the delivery itself. Some lower Apgar scores observed
in the misoprostol group requires further investigation.

Abstract

Objectives: Induction of labour is a part of an active prenatal care nowadays and the ideal method of that procedure still
remains to be identified. The purpose of this study was to evaluate effectiveness of misoprostol vaginal insert as compared
to dinoprostone gel for delivery induction in pregnant women without any comorbidities.
Material and methods: It was a retrospective cohort study of 240 pregnant women. The primary study outcome was
successful delivery. Other analysed parameters included time to delivery of a baby, time to the beginning of the first stage
of labour, time to vaginal delivery, and duration of all delivery stages. We compared both methods regarding maternal
complications during and after delivery. We also reviewed neonatal outcomes such as birth weight, birth length and
1-minute Apgar scores.
Results: The patients’ basic characteristics were similar regarding their age, gravidity, parity, height, weight and Bishop
score. Time to any delivery and to the onset of a labour in the misoprostol group versus in the dinoprostone group was
14.5 vs 35.6 h (p < 0.001) and 9.9 h vs 25.3 h (p < 0.001) respectively. The chance of the beginning of labour and the baby’s
delivery over time has been observed to be approximately two times higher for misoprostol as compared to dinoprostone.
Conclusions: Our study showed that using misoprostol vaginal insert in comparison to dinoprostone seems to shorten the
time to beginning of the first stage of labour as well as the time to the delivery itself. Some lower Apgar scores observed
in the misoprostol group requires further investigation.

Get Citation

Keywords

misoprostol; dinoprostone; induction of labor

About this article
Title

Comparison of Misoprostol versus Dinoprostone for delivery induction among pregnant women without concomitant disease

Journal

Ginekologia Polska

Issue

Vol 91, No 12 (2020)

Article type

Research paper

Pages

726-732

Published online

2020-12-31

DOI

10.5603/GP.2020.0119

Pubmed

33447991

Bibliographic record

Ginekol Pol 2020;91(12):726-732.

Keywords

misoprostol
dinoprostone
induction of labor

Authors

Teresa Gornisiewicz
Katarzyna Kusmierska-Urban
Hubert Huras
Aleksander Galas

References (13)
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  2. Induction of Labour. Society of Obstetricians and Gynaecologist of Canada Clinical Practise Guideline No 296. J Obstet and Gynecol Canada. 2013; 35: s1–s18.
  3. Huras H, Radoń-Pokracka M, Górnisiewicz T. Indukcja porodu w świetle aktualnego piśmiennictwa. Ginekol Położ. 2016; 11(1): 21–25.
  4. Leszczyńska-Gorzelak B, Laskowska M, Oleszczuk J. Comparative analysis of the effectiveness of misoprostol and prostaglandin E(2) in the preinduction and induction of labor. Med Sci Monit. 2001; 7(5): 1023–1028.
  5. Dögl M, Vanky E, Heimstad R. Changes in induction methods have not influenced cesarean section rates among women with induced labor. Acta Obstet Gynecol Scand. 2016; 95(1): 112–115.
  6. Bomba-Opoń D, Drews K, Huras H, et al. Indukcja porodu — algorytmy kliniczne. Wytyczne Polskiego Towarzystwa Ginekologów i Położników. Ginekologia i Perinatologia Praktyczna. 2018; 3(1): 23–29.
  7. Sharp A, Faluyi D, Alfirevic Z. Misoprostol vaginal insert (Mysodelle) versus Dinoprostone intravaginal gel (Prostin) for induction of labour. Eur J Obstet Gynecol Reprod Biol. 2019; 240: 41–44.
  8. Wing DA, Brown R, Plante LA, et al. Misoprostol vaginal insert and time to vaginal delivery: a randomized controlled trial. Obstet Gynecol. 2013; 122(2 Pt 1): 201–209.
  9. Górnisiewicz T, Jaworowski A, Zembala-Szczerba M, et al. Analysis of intravaginal misoprostol 0.2 mg versus intracervical dinoprostone 0.5 mg doses for labor induction at term pregnancies. Ginekol Pol. 2017; 88(6): 320–324.
  10. Bolla D, Weissleder SV, Radan AP, et al. Misoprostol vaginal insert versus misoprostol vaginal tablets for the induction of labour: a cohort study. BMC Pregnancy Childbirth. 2018; 18(1): 149.
  11. Eriksson A, Jeppesen S, Krebs L. Induction of labour in nulliparous women- quick or slow: a cohort study comparing slow-release vaginal insert with low-dose misoprostol oral tablets. BMC Pregnancy Childbirth. 2020; 20(1): 79.
  12. Maggi C, Mazzoni G, Gerosa V, et al. Labor induction with misoprostol vaginal insert compared with dinoprostone vaginal insert. Acta Obstet Gynecol Scand. 2019; 98(10): 1268–1273.
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