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Assessment of selected parameters of placental microstructure in patients with intrahepatic cholestasis of pregnancy
Affiliations- Gynecologic and Obstetrical University Hospital in Poznan, Poland
- Division of Reproduction, Department of Obstetrics, Gynaecology and Gynaecologic Oncology, Poznan University of Medical Sciences, Poznan, Poland
open access
Abstract
Objectives: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder during pregnancy. Cholestasis is associated with increased risk of fetal complications: prematurity, perinatal hypoxia and meconium stained amniotic fluid, and sudden intrauterine fetal death. The exact mechanisms associated with cholestasis fetal sequelae are not fully understood. The aim of the study was the histopathological evaluation of placentas from patients with cholestasis and healthy pregnant women to establish whether cholestasis is accompanied by changes in placental microstructure.
Material and methods: The effect of cholestasis on placental microstructure was investigated using placental tissue from patients with cholestatsis treated with ursodeoxycholic acid (UDCA) and from uncomplicated pregnancies. Five placental histopathological features were analyzed: number of syncytial knots, number of capillaries per villous, structure of stroma, presence of Hofbauer cells, and villitis of unknown etiology.
Results: There were no statistically significant differences in any of the studied parameters between cholestasis-affected and healthy control groups.
Conclusions: There are no diffrences in placental microstructure in cholestasis patients treated with UDCA and in patients with uncomplicated pregnancy.
Abstract
Objectives: Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder during pregnancy. Cholestasis is associated with increased risk of fetal complications: prematurity, perinatal hypoxia and meconium stained amniotic fluid, and sudden intrauterine fetal death. The exact mechanisms associated with cholestasis fetal sequelae are not fully understood. The aim of the study was the histopathological evaluation of placentas from patients with cholestasis and healthy pregnant women to establish whether cholestasis is accompanied by changes in placental microstructure.
Material and methods: The effect of cholestasis on placental microstructure was investigated using placental tissue from patients with cholestatsis treated with ursodeoxycholic acid (UDCA) and from uncomplicated pregnancies. Five placental histopathological features were analyzed: number of syncytial knots, number of capillaries per villous, structure of stroma, presence of Hofbauer cells, and villitis of unknown etiology.
Results: There were no statistically significant differences in any of the studied parameters between cholestasis-affected and healthy control groups.
Conclusions: There are no diffrences in placental microstructure in cholestasis patients treated with UDCA and in patients with uncomplicated pregnancy.
Keywords
intrahepatic cholestasis of pregnancy; ursodeoxycholic acid; placenta; histology
About this articleTitle
Assessment of selected parameters of placental microstructure in patients with intrahepatic cholestasis of pregnancy
Journal
Issue
Article type
Research paper
Pages
452-457
Published online
2019-08-30
Page views
1317
Article views/downloads
1205
DOI
Pubmed
Bibliographic record
Ginekol Pol 2019;90(8):452-457.
Keywords
intrahepatic cholestasis of pregnancy
ursodeoxycholic acid
placenta
histology
Authors
Milena Gruszczynska-Losy
Ewa Wender-Ozegowska
Przemyslaw Wirstlein
Malgorzata Szczepanska
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