open access

Vol 94, No 7 (2023)
Research paper
Published online: 2023-02-10
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Does body mass index affect anti-mullerian hormone levels in girls and adolescents?

Iwona J. Czech1, Miroslaw Partyka2, Agnieszka Drosdzol-Cop1
·
Pubmed: 36929787
·
Ginekol Pol 2023;94(7):524-526.
Affiliations
  1. Chair and Department of Gynecology, Obstetrics and Oncological Gynecology, Medical University of Silesia in Katowice, Poland
  2. Laboratory Diagnostics Department of the Upper Silesian Child Health Center in Katowice, Poland

open access

Vol 94, No 7 (2023)
ORIGINAL PAPERS Gynecology
Published online: 2023-02-10

Abstract

Objectives: Anti-mullerian hormone (AMH) is a dimeric glycoprotein which belongs to the transforming growth factor- beta superfamily. In women, it is produced by granulosa cells in pre-antral and small antral follicles. In recent years, there has been a continuous increase in obesity among children and adolescents. There are few studies that present AMH concentrations in premenarcheal and early postmenarcheal girls. The purpose of this work is to assess whether AMH levels were associated with body mass index (BMI) in adolescent girls before and after menarche.

Material and methods: The study was performed at the Pediatric Endocrinology Department and Outpatient Clinic at Upper Silesian Child Health Center. 82 girls were enrolled to the study.

Results: There were no statistically important differences between AMH levels in menstruating and non-menstruating girls depending on BMI.

Conclusions: Body mass index seems not to affect the AMH levels in adolescents, however a special attention must be given when interpreting AMH levels in girls with irregular menstrual cycles and observed for PCOS.

Abstract

Objectives: Anti-mullerian hormone (AMH) is a dimeric glycoprotein which belongs to the transforming growth factor- beta superfamily. In women, it is produced by granulosa cells in pre-antral and small antral follicles. In recent years, there has been a continuous increase in obesity among children and adolescents. There are few studies that present AMH concentrations in premenarcheal and early postmenarcheal girls. The purpose of this work is to assess whether AMH levels were associated with body mass index (BMI) in adolescent girls before and after menarche.

Material and methods: The study was performed at the Pediatric Endocrinology Department and Outpatient Clinic at Upper Silesian Child Health Center. 82 girls were enrolled to the study.

Results: There were no statistically important differences between AMH levels in menstruating and non-menstruating girls depending on BMI.

Conclusions: Body mass index seems not to affect the AMH levels in adolescents, however a special attention must be given when interpreting AMH levels in girls with irregular menstrual cycles and observed for PCOS.

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Keywords

AMH; BMI; obesity; adolescents; pediatric endocrinology

About this article
Title

Does body mass index affect anti-mullerian hormone levels in girls and adolescents?

Journal

Ginekologia Polska

Issue

Vol 94, No 7 (2023)

Article type

Research paper

Pages

524-526

Published online

2023-02-10

Page views

1079

Article views/downloads

327

DOI

10.5603/GP.a2023.0013

Pubmed

36929787

Bibliographic record

Ginekol Pol 2023;94(7):524-526.

Keywords

AMH
BMI
obesity
adolescents
pediatric endocrinology

Authors

Iwona J. Czech
Miroslaw Partyka
Agnieszka Drosdzol-Cop

References (9)
  1. Drosdzol-Cop A, Dulska A, Czech I. Otyłość a problemy ginekologiczne wieku dziecięcego. In: Olszanecka-Glinianowicz M. ed. Obesitologia kliniczna. Alfa-medica press, Bielsko-Biała 2021.
  2. Ng M, Fleming T, Robinson M, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014; 384(9945): 766–781.
  3. World Health Organization. Adolescent obesity and related behaviours: trends and inequalities in the WHO European Region, 2002–2014.
  4. McCartney CR, Blank SK, Prendergast KA, et al. Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girls. J Clin Endocrinol Metab. 2007; 92(2): 430–436.
  5. Drosdzol-Cop A, Orszulak D. Zespół policystycznych jajników u dziewcząt w wieku nastoletnim. In: Olszanecka-Glinianowicz M. ed. Obesitologia kliniczna. Alfa-medica press, Bielsko-Biała 2021.
  6. Oldfield AL, Kazemi M, Lujan ME. Impact of Obesity on Anti-Mullerian Hormone (AMH) Levels in Women of Reproductive Age. J Clin Med. 2021; 10(14).
  7. Kriseman M, Mills C, Kovanci E, et al. Antimullerian hormone levels are inversely associated with body mass index (BMI) in women with polycystic ovary syndrome. J Assist Reprod Genet. 2015; 32(9): 1313–1316.
  8. Cengiz H, Ekin M, Dagdeviren H, et al. Comparison of serum anti-Müllerian hormone levels in normal weight and overweight-obese adolescent patients with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2014; 180: 46–50.
  9. Kim JY, Tfayli H, Michaliszyn SF, et al. Anti-Müllerian Hormone in Obese Adolescent Girls With Polycystic Ovary Syndrome. J Adolesc Health. 2017; 60(3): 333–339.

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