open access

Vol 94, No 4 (2023)
Research paper
Published online: 2022-05-12
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Hematological and biochemical markers in determining the diagnosis and stage prediction of endometrial cancer

Aleksandra Nadezda Petric12, Radomir Živadinović12, Dejan Mitić12, Marko Stanojević2, Aleksandar Živadinović2, Ivana Kostić3
·
Pubmed: 35894501
·
Ginekol Pol 2023;94(4):283-290.
Affiliations
  1. Gynecology and Obstetrics Clinic, University Clinical Center Niš, Serbia
  2. Faculty of Medicine, University of Niš, Serbia
  3. Health Center Niš, Serbia

open access

Vol 94, No 4 (2023)
ORIGINAL PAPERS Gynecology
Published online: 2022-05-12

Abstract

Objectives: To establish whether there is a statistically significant difference in hematological and biochemical parameters between the patients with premalignant changes of the uterine mucosa and those with malignant changes. The aim is to establish whether hematological and biochemical parameters may be useful in predicting the stages of endometrial malignancy and in differentiating premalignant and malignant endometrial changes.
Material and methods: A retrospective study included 100 patients (70 with endometrial carcinoma diagnosis and 30 with atypical hyperplasia). We compared hematological and biochemical parameters in both groups.
Results: CRP, granulocytes, platelets, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) are statistically significantly higher in patients with malignant changes. Lymphocyte count is statistically significantly lower in patients with malignant changes. Platelet count is statistically significantly lower in patients with stages I and II in comparison to patients with higher disease stage. NLR and PLR have good discriminatory power for carcinoma presence. Patients with advanced changes have statistically significantly higher CRP values, higher granulocyte and platelet count, as well as higher values of NLR and PLR, and statistically significantly lower values of lymphocytes and MPV in comparison to
benign changes.
Conclusions: There is a possibility of using hematological and biochemical parameters in the assessment of endometrial changes as well as in the prediction of stages, in confirmed malignant changes of the endometrium.

Abstract

Objectives: To establish whether there is a statistically significant difference in hematological and biochemical parameters between the patients with premalignant changes of the uterine mucosa and those with malignant changes. The aim is to establish whether hematological and biochemical parameters may be useful in predicting the stages of endometrial malignancy and in differentiating premalignant and malignant endometrial changes.
Material and methods: A retrospective study included 100 patients (70 with endometrial carcinoma diagnosis and 30 with atypical hyperplasia). We compared hematological and biochemical parameters in both groups.
Results: CRP, granulocytes, platelets, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) are statistically significantly higher in patients with malignant changes. Lymphocyte count is statistically significantly lower in patients with malignant changes. Platelet count is statistically significantly lower in patients with stages I and II in comparison to patients with higher disease stage. NLR and PLR have good discriminatory power for carcinoma presence. Patients with advanced changes have statistically significantly higher CRP values, higher granulocyte and platelet count, as well as higher values of NLR and PLR, and statistically significantly lower values of lymphocytes and MPV in comparison to
benign changes.
Conclusions: There is a possibility of using hematological and biochemical parameters in the assessment of endometrial changes as well as in the prediction of stages, in confirmed malignant changes of the endometrium.

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Keywords

endometrial cancer; hematological parameters; biochemical parameters; stage

About this article
Title

Hematological and biochemical markers in determining the diagnosis and stage prediction of endometrial cancer

Journal

Ginekologia Polska

Issue

Vol 94, No 4 (2023)

Article type

Research paper

Pages

283-290

Published online

2022-05-12

Page views

2384

Article views/downloads

577

DOI

10.5603/GP.a2022.0038

Pubmed

35894501

Bibliographic record

Ginekol Pol 2023;94(4):283-290.

Keywords

endometrial cancer
hematological parameters
biochemical parameters
stage

Authors

Aleksandra Nadezda Petric
Radomir Živadinović
Dejan Mitić
Marko Stanojević
Aleksandar Živadinović
Ivana Kostić

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