open access

Vol 94, No 6 (2023)
Research paper
Published online: 2022-05-06
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Expression and clinical significance of lncRNA NORAD in patients with gestational hypertension

Zhengjiao Liang1, Li Wang1
·
Pubmed: 35894504
·
Ginekol Pol 2023;94(6):429-434.
Affiliations
  1. Department of Obstetrics and Gynecology, Anhui No.2 Provincial People’s Hospital, China

open access

Vol 94, No 6 (2023)
ORIGINAL PAPERS Gynecology
Published online: 2022-05-06

Abstract

Objectives: Gestational hypertension (GH), the most common type of hypertensive disorders in pregnancy, often occurs in women during pregnancy. The purpose of this study was to investigate the expression and clinical significance of lncRNA NORAD in gestational hypertension, and to discuss the possibility of lncRNA NORAD as a diagnostic marker of gestational hypertension.

Material and methods: A total of 219 participants were involved in the study. Basic clinical information of all participants was collected, and the expression of NORAD in serum was detected by RT-qPCR. ROC curves were drawn to evaluate the diagnostic value of NORAD expression for gestational hypertension. Multiple linear regression analysis was done to explore the relationship between NORAD and clinical variables. Logistic regression analysis was conducted to analyze the independent influence of different variables on the development of gestational hypertension into preeclampsia.

Results: The expression level of NORAD in gestational hypertension was higher than that of healthy individuals, and the expression level of NORAD in preeclampsia was higher than that of gestational hypertension and healthy individuals. The ROC curve suggested that the expression of NORAD has a higher diagnostic value for gestational hypertension. Multiple linear regression analysis showed that systolic blood pressure (SBP) and diastolic blood pressure (DBP) were correlated with the expression of NORAD. SBP, DBP and NORAD were all factors that affect the development of gestational hypertension to preeclampsia, which were known by Logistic regression analysis.

Conclusions: LncRNA NORAD may be used as a biomarker for gestational hypertension diagnosis and can influence its progression into preeclampsia.

Abstract

Objectives: Gestational hypertension (GH), the most common type of hypertensive disorders in pregnancy, often occurs in women during pregnancy. The purpose of this study was to investigate the expression and clinical significance of lncRNA NORAD in gestational hypertension, and to discuss the possibility of lncRNA NORAD as a diagnostic marker of gestational hypertension.

Material and methods: A total of 219 participants were involved in the study. Basic clinical information of all participants was collected, and the expression of NORAD in serum was detected by RT-qPCR. ROC curves were drawn to evaluate the diagnostic value of NORAD expression for gestational hypertension. Multiple linear regression analysis was done to explore the relationship between NORAD and clinical variables. Logistic regression analysis was conducted to analyze the independent influence of different variables on the development of gestational hypertension into preeclampsia.

Results: The expression level of NORAD in gestational hypertension was higher than that of healthy individuals, and the expression level of NORAD in preeclampsia was higher than that of gestational hypertension and healthy individuals. The ROC curve suggested that the expression of NORAD has a higher diagnostic value for gestational hypertension. Multiple linear regression analysis showed that systolic blood pressure (SBP) and diastolic blood pressure (DBP) were correlated with the expression of NORAD. SBP, DBP and NORAD were all factors that affect the development of gestational hypertension to preeclampsia, which were known by Logistic regression analysis.

Conclusions: LncRNA NORAD may be used as a biomarker for gestational hypertension diagnosis and can influence its progression into preeclampsia.

Get Citation

Keywords

lncRNA NORAD; gestational hypertension; preeclampsia; diagnostic

About this article
Title

Expression and clinical significance of lncRNA NORAD in patients with gestational hypertension

Journal

Ginekologia Polska

Issue

Vol 94, No 6 (2023)

Article type

Research paper

Pages

429-434

Published online

2022-05-06

Page views

1688

Article views/downloads

462

DOI

10.5603/GP.a2022.0016

Pubmed

35894504

Bibliographic record

Ginekol Pol 2023;94(6):429-434.

Keywords

lncRNA NORAD
gestational hypertension
preeclampsia
diagnostic

Authors

Zhengjiao Liang
Li Wang

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