Vol 93, No 11 (2022)
Research paper
Published online: 2022-10-03

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Endometrial regeneration in Asherman’s syndrome and endometrial atrophy using Wharton’s jelly-derived mesenchymal stem cells

Jaroslaw B. Kaczynski12, Jakub K. Rzepka12
Pubmed: 36196566
Ginekol Pol 2022;93(11):904-909.

Abstract

Objectives: Reconstruction of the endometrium in patients with endometrial atrophy and Asherman’s syndrome using
Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs).

Material and methods: Prospective pilot study, with the inclusion of two patients.

Results: After administration of WJ-MSCs into the uterine cavity, endometrial reconstruction was achieved in both patients. Pregnancy was achieved in one of them, after transfer of a frozen embryo, completed by delivery around the due date.

Conclusions: Endometrial atrophy and Asherman’s syndrome, is one of the most frustrating clinical situations we face
in assisted reproductive procedures. The use of Wharton’s jelly-derived mesenchymal stem cells in restoring the normal
function of the endometrium, could become an easy and accessible therapeutic medal, for this endometrial dysfunction,
which is so difficult to treat.

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