open access
Plasma microRNAs can be a potential diagnostic biomarker for endometriosis
Affiliations- HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China
open access
Abstract
Objectives: Plasma microRNAs are considered potential diagnostic biomarkers for endometriosis. Increasing evidence has shown that a huge number of miRNAs are abnormally expressed in endometriosis plasma and play irreplaceable roles in diagnosis.
Material and methods: The aim of our study was to identify the differential expression of circular miRNA by reviewing the PubMed, ScienceDirect, and Cochrane databases between normal women and women with endometriosis and analyzing the miRNA data downloaded from the GEO database.
Results: Because of the differential miRNA expression in this review, we evaluated the diagnostic values of the differentially expressed miRNAs, particularly during the menstrual phases. According to the cut-off criteria with |log 2 FC| > 1.0 and P < 0.05, 36 differentially expressed miRNAs were identified, including 13 upregulated miRNAs and 23 downregulated miRNAs. We developed miR-155, miR-574, miR-23a, and miR-520d via a Venn diagram. Functional enrichment analysis considered that the target miRNAs might be involved in various pathways related to endometriosis, including neurotrophin, Hippo, oocyte meiosis, ubiquitin mediated proteolysis, HTLV-Infection, FoxO, and Rap1 signaling pathways. CTNNB1, MYC, and ES R1 of transcription factors were related to the differentially expressed miRNAs.
Conclusions: In summary, our study suggested that a four-miRNA could be included as a prognostic marker in endometriosis.
Abstract
Objectives: Plasma microRNAs are considered potential diagnostic biomarkers for endometriosis. Increasing evidence has shown that a huge number of miRNAs are abnormally expressed in endometriosis plasma and play irreplaceable roles in diagnosis.
Material and methods: The aim of our study was to identify the differential expression of circular miRNA by reviewing the PubMed, ScienceDirect, and Cochrane databases between normal women and women with endometriosis and analyzing the miRNA data downloaded from the GEO database.
Results: Because of the differential miRNA expression in this review, we evaluated the diagnostic values of the differentially expressed miRNAs, particularly during the menstrual phases. According to the cut-off criteria with |log 2 FC| > 1.0 and P < 0.05, 36 differentially expressed miRNAs were identified, including 13 upregulated miRNAs and 23 downregulated miRNAs. We developed miR-155, miR-574, miR-23a, and miR-520d via a Venn diagram. Functional enrichment analysis considered that the target miRNAs might be involved in various pathways related to endometriosis, including neurotrophin, Hippo, oocyte meiosis, ubiquitin mediated proteolysis, HTLV-Infection, FoxO, and Rap1 signaling pathways. CTNNB1, MYC, and ES R1 of transcription factors were related to the differentially expressed miRNAs.
Conclusions: In summary, our study suggested that a four-miRNA could be included as a prognostic marker in endometriosis.
Keywords
endometriosis; circular; microRNA; diagnosis; plasma
About this articleTitle
Plasma microRNAs can be a potential diagnostic biomarker for endometriosis
Journal
Issue
Article type
Research paper
Pages
450-459
Published online
2021-06-17
Page views
6161
Article views/downloads
2055
DOI
Pubmed
Bibliographic record
Ginekol Pol 2022;93(6):450-459.
Keywords
endometriosis
circular
microRNA
diagnosis
plasma
Authors
Zhihong Zhuo
Chuhan Wang
Huimin Yu
References (36)- Chen L, Kang C. miRNA interventions serve as 'magic bullets' in the reversal of glioblastoma hallmarks. Oncotarget. 2015; 6(36): 38628–38642.
- Lee R, Feinbaum R, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993; 75(5): 843–854.
- Pasquinelli AE, Reinhart BJ, Slack F, et al. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature. 2000; 408(6808): 86–89.
- Lim LP, Lau NC, Garrett-Engele P, et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005; 433(7027): 769–773.
- Teague EM, Print CG, Hull ML. The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update. 2010; 16(2): 142–165.
- Caporali A, Emanueli C. MicroRNA regulation in angiogenesis. Vascul Pharmacol. 2011; 55(4): 79–86.
- Bartel DP, Chen CZ. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet. 2004; 5(5): 396–400.
- Lagos-Quintana M, Rauhut R, Lendeckel W, et al. Identification of novel genes coding for small expressed RNAs. Science. 2001; 294(5543): 853–858.
- Mitchell PS, Parkin RK, Kroh EM, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2008; 105(30): 10513–10518.
- Small EM, Olson EN. Pervasive roles of microRNAs in cardiovascular biology. Nature. 2011; 469(7330): 336–342.
- Lawrie CH, Gal S, Dunlop HM, et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol. 2008; 141(5): 672–675.
- D'Alessandra Y, Devanna P, Limana F, et al. Circulating microRNAs are new and sensitive biomarkers of myocardial infarction. Eur Heart J. 2010; 31(22): 2765–2773.
- Vodolazkaia A, El-Aalamat Y, Popovic D, et al. Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endometriosis. Hum Reprod. 2012; 27(9): 2698–2711.
- Giudice LC, Kao LC. Endometriosis . Lancet. 2004; 364(9447): 1789–1799.
- Tamaresis JS, Irwin JC, Goldfien GA, et al. Molecular classification of endometriosis and disease stage using high-dimensional genomic data. Endocrinology. 2014; 155(12): 4986–4999.
- Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010; 362(25): 2389–2398.
- Tokushige N, Markham R, Crossett B, et al. Discovery of a novel biomarker in the urine in women with endometriosis. Fertil Steril. 2011; 95(1): 46–49.
- Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012; 98(3): 511–519.
- Jia SZ, Yang Y, Lang J, et al. Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis. Hum Reprod. 2013; 28(2): 322–330.
- Fassbender A, Vodolazkaia A, Saunders P, et al. Biomarkers of endometriosis. Fertil Steril. 2013; 99(4): 1135–1145.
- Cho S, Mutlu L, Grechukhina O, et al. Circulating microRNAs as potential biomarkers for endometriosis. Fertil Steril. 2015; 103(5): 1252–12560.e1.
- Cosar E, Mamillapalli R, Ersoy GS, et al. Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis. Fertil Steril. 2016; 106(2): 402–409.
- Suryawanshi S, Vlad AM, Lin HM, et al. Plasma microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer. Clin Cancer Res. 2013; 19(5): 1213–1224.
- Wang WT, Zhao YN, Han BW, et al. Circulating microRNAs identified in a genome-wide serum microRNA expression analysis as noninvasive biomarkers for endometriosis. J Clin Endocrinol Metab. 2013; 98(1): 281–289.
- Wang L, Huang W, Ren C, et al. Analysis of serum microRNA profile by solexa sequencing in women with endometriosis. Reprod Sci. 2016; 23(10): 1359–1370.
- Nothnick WB, Falcone T, Joshi N, et al. Serum miR-451a levels are significantly elevated in women with endometriosis and recapitulated in baboons (papio anubis) with experimentally-induced disease. Reprod Sci. 2017; 24(8): 1195–1202.
- Maged AM, Deeb WS, El Amir A, et al. Diagnostic accuracy of serum miR-122 and miR-199a in women with endometriosis. Int J Gynaecol Obstet. 2018; 141(1): 14–19.
- Wang F, Wang H, Jin D, et al. Serum miR-17, IL-4, and IL-6 levels for diagnosis of endometriosis. Medicine (Baltimore). 2018; 97(24): e10853.
- Rekker K, Saare M, Roost AM, et al. Circulating miR-200-family micro-RNAs have altered plasma levels in patients with endometriosis and vary with blood collection time. Fertil Steril. 2015; 104(4): 938–946.e2.
- Pateisky P, Pils D, Szabo L, et al. hsa-miRNA-154-5p expression in plasma of endometriosis patients is a potential diagnostic marker for the disease. Reprod Biomed Online. 2018; 37(4): 449–466.
- Shakiba K, Bena JF, McGill KM, et al. Surgical treatment of endometriosis: a 7-year follow-up on the requirement for further surgery. Obstet Gynecol. 2008; 111(6): 1285–1292.
- Johnson NP, Hummelshoj L, Johnson NP, et al. World Endometriosis Society Montpellier Consortium. Consensus on current management of endometriosis. Hum Reprod. 2013; 28(6): 1552–1568.
- Nnoaham KE, Hummelshoj L, Webster P, et al. World Endometriosis Research Foundation Global Study of Women's Health consortium. Impact of endometriosis on quality of life and work productivity: a multicenter study across ten countries. Fertil Steril. 2011; 96(2): 366–373.e8.
- Pan Q, Chegini N. MicroRNA signature and regulatory functions in the endometrium during normal and disease states. Semin Reprod Med. 2008; 26(6): 479–493.
- Dai L, Gu L, Di W. MiR-199a attenuates endometrial stromal cell invasiveness through suppression of the IKK /NF- B pathway and reduced interleukin-8 expression. Molecular Human Reproduction. 2011; 18(3): 136–145.
- Ramón LA, Braza-Boïls A, Gilabert-Estellés J, et al. microRNAs expression in endometriosis and their relation to angiogenic factors. Hum Reprod. 2011; 26(5): 1082–1090.
