Vol 92, No 9 (2021)
Review paper
Published online: 2021-08-06

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On the border of medical specialties: ovarian metastasis from colorectal cancer

Katarzyna A. Kowalczyk123, Wojciech M. Wysocki124
Pubmed: 34541653
Ginekol Pol 2021;92(9):659-662.


The colon cancer (CC) is the fourth most common cancer in the world. It is associated with metastatic spread in 50% of cases in the course of the disease. Common sites for synchronous metastases from colorectal cancer are the lung, liver, peritoneum, bone and brain. The frequency of ovarian metastasis from CC varies widely from 1.6 to 7.4%. This type of metastasis is difficult to distinguish clinically from primary ovarian neoplasms. We present a case of a 49-years old woman admitted to the Department of General Surgery at the 5th Military Clinical Hospital in Cracow for elective surgery for metastatic obstructive sigmoid cancer. Computed tomography (CT) showed a large tumor in the right ovarian field. Brief recommendations regarding that issue based on the available literature has been summarized as well.

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  1. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019; 14(2): 89–103.
  2. Jervis MJ, Rodrigues C, Cabral D, et al. Surgical Approach to Colorectal Cancer Pulmonary Metastasis - One-year Experience of a Reference Center. Rev Port Cir Cardiotorac Vasc. 2019; 26(2): 117–119.
  3. Shimazaki J, Tabuchi T, Nishida K, et al. Synchronous ovarian metastasis from colorectal cancer: A report of two cases. Oncol Lett. 2016; 12(1): 257–261.
  4. Garg S, Dasappa L, Lakshmaiah KC, et al. Colorectal cancer presenting as ovarian metastasis. Clin Cancer Investig J. 2017; 6(1): 92–96.
  5. Challa VR, Goud YG, Rangappa P, et al. "Ovarian Metastases from Colorectal Cancer: Our Experience". Indian J Surg Oncol. 2015; 6(2): 95–98.
  6. Wright JD, Powell MA, Mutch DG, et al. Synchronous ovarian metastases at the time of laparotomy for colon cancer. Gynecol Oncol. 2004; 92(3): 851–855.
  7. Mori Y, Nyuya A, Yasui K, et al. Clinical outcomes of women with ovarian metastases of colorectal cancer treated with oophorectomy with respect to their somatic mutation profiles. Oncotarget. 2018; 9(23): 16477–16488.
  8. Miller BE, Pittman B, Wan JY, et al. Colon cancer with metastasis to the ovary at time of initial diagnosis. Gynecol Oncol. 1997; 66(3): 368–371.
  9. Lee SuJ, Lee J, Lim HoY, et al. Survival benefit from ovarian metastatectomy in colorectal cancer patients with ovarian metastasis: a retrospective analysis. Cancer Chemother Pharmacol. 2010; 66(2): 229–235.
  10. Muthukrishnan S, Naganathbabu OL, Murugesan SD, et al. Krukenberg tumours from gastrointestinal cancers-analysis from a tertiary care centre in India. J Gastrointest Oncol. 2018; 9(6): 1164–1167.
  11. de Waal YRP, Thomas CMG, Oei ALM, et al. Secondary ovarian malignancies: frequency, origin, and characteristics. Int J Gynecol Cancer. 2009; 19(7): 1160–1165.
  12. Lee InK, Kim DoH, Gorden DL, et al. Prognostic value of CEA and CA 19-9 tumor markers combined with cytology from peritoneal fluid in colorectal cancer. Ann Surg Oncol. 2009; 16(4): 861–870.
  13. Segelman J, Flöter-Rådestad A, Hellborg H, et al. Epidemiology and prognosis of ovarian metastases in colorectal cancer. Br J Surg. 2010; 97(11): 1704–1709.
  14. Koneczny J, Czekierdowski A, Florczak M, et al. The use of sonographic subjective tumor assessment, IOTA logistic regression model 1, IOTA Simple Rules and GI-RADS system in the preoperative prediction of malignancy in women with adnexal masses. Ginekol Pol. 2017; 88(12): 647–653.
  15. Sielezneff I, Salle E, Antoine K, et al. Simultaneous bilateral oophorectomy does not improve prognosis of postmenopausal women undergoing colorectal resection for cancer. Dis Colon Rectum. 1997; 40(11): 1299–1302.
  16. Wysocki W, Kojs Z, Mituś J, et al. Prophylactic ovariectomy in patients with colorectal cancer: is it justified? Current Gynecologic Oncology. 2013; 11(1): 55–61.
  17. Thompson C. Prophylactic oophorectomy during primary colorectal cancer resection: A systematic review and meta-analysis. World Journal of Surgical Procedures. 2015; 5(1): 167.