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Research paper
Published online: 2021-04-20
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Does intraoperative application of TachoSil reduce the number of lymphoceles after pelvic lymphadenectomy?

Andrzej Wrobel1, Izabela Winkler2, Tomasz Rechberger1, Katarzyna Skorupska1, Pawel Miotla1
DOI: 10.5603/GP.a2021.0065
·
Pubmed: 33914319
Affiliations
  1. 2nd Department of Gynecology, Medical University of Lublin, Poland
  2. 2nd Department of Gynecology, St' Johns Centre Oncology, Lublin, Poland

open access

Ahead of Print
ORIGINAL PAPERS Gynecology
Published online: 2021-04-20

Abstract

Objectives: The degree of lymphoceles prevention was assessed using collagen patches coated with human coagulation factors (TachoSil, Nycomed International Management GmbH, Zurich, Switzerland). The study enrolled 50 consecutive patients with endometrial and cervical cancer stages IB to II who had undergone open hysterectomy and pelvic lymphadenectomy (PL). In addition, the drainage volumes of 22 patients with hypertension were compared to that of the rest of the study population. Furthermore, occurrence of lymphocele in patients with endometrial and cervical cancer were compared after completion of adjuvant treatment.

Material and methods: Patients were simultaneously randomized in two groups: as a control (side without TachoSil applied) and study group (side with TachoSil applied). All surgical parameters were collected, and patients underwent ultrasound examination on postoperative days 1, 6, and 30, and at the end of treatment.

Results: The TachoSil Group showed a lower drainage volume, 30 days after surgery, while outflow of fluid occurred in 11 (22%) of all TachoSil Group cases and 22 (44%) of all control group cases. Furthermore, two patients in the control group had symptomatic lymphocele, while the same number of cases was observed in the TachoSil Group. However, the TachoSil Group demonstrated a decreased tendency to lymphocele occurrence after the end of adjuvant therapy. Here, patients with the collagen patch developed lymphocele in 12% of all cases, as opposed to 18% without TachoSil.

Conclusions: TachoSil is a useful support treatment option for reducing drainage volume and preventing lymphocele development after lymphadenectomy.

Abstract

Objectives: The degree of lymphoceles prevention was assessed using collagen patches coated with human coagulation factors (TachoSil, Nycomed International Management GmbH, Zurich, Switzerland). The study enrolled 50 consecutive patients with endometrial and cervical cancer stages IB to II who had undergone open hysterectomy and pelvic lymphadenectomy (PL). In addition, the drainage volumes of 22 patients with hypertension were compared to that of the rest of the study population. Furthermore, occurrence of lymphocele in patients with endometrial and cervical cancer were compared after completion of adjuvant treatment.

Material and methods: Patients were simultaneously randomized in two groups: as a control (side without TachoSil applied) and study group (side with TachoSil applied). All surgical parameters were collected, and patients underwent ultrasound examination on postoperative days 1, 6, and 30, and at the end of treatment.

Results: The TachoSil Group showed a lower drainage volume, 30 days after surgery, while outflow of fluid occurred in 11 (22%) of all TachoSil Group cases and 22 (44%) of all control group cases. Furthermore, two patients in the control group had symptomatic lymphocele, while the same number of cases was observed in the TachoSil Group. However, the TachoSil Group demonstrated a decreased tendency to lymphocele occurrence after the end of adjuvant therapy. Here, patients with the collagen patch developed lymphocele in 12% of all cases, as opposed to 18% without TachoSil.

Conclusions: TachoSil is a useful support treatment option for reducing drainage volume and preventing lymphocele development after lymphadenectomy.

Get Citation

Keywords

lymphocele; endometrial cancer; lymphadenectomy; cervical cancer; collagen patch

About this article
Title

Does intraoperative application of TachoSil reduce the number of lymphoceles after pelvic lymphadenectomy?

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2021-04-20

DOI

10.5603/GP.a2021.0065

Pubmed

33914319

Keywords

lymphocele
endometrial cancer
lymphadenectomy
cervical cancer
collagen patch

Authors

Andrzej Wrobel
Izabela Winkler
Tomasz Rechberger
Katarzyna Skorupska
Pawel Miotla

References (14)
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  2. Frost JA, Webster KE, Bryant A, et al. Lymphadenectomy for the management of endometrial cancer. Cochrane Database Syst Rev. 2015(9): CD007585.
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