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Vol 92, No 6 (2021)
Review paper
Published online: 2021-04-29
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Vitamin D3 and its receptor in selected obstetrical complications

Justyna Magielda-Stola1, Krzysztof Drews1, Hubert Wolski12, Agnieszka Seremak-Mrozikiewicz1
DOI: 10.5603/GP.a2021.0088
·
Pubmed: 33914313
·
Ginekol Pol 2021;92(6):460-465.
Affiliations
  1. Division of Perinatology and Women’s Disease, Poznan University of Medical Sciences, Poznan, Poland
  2. Division of Obstetrics and Gynecology, Hospital Zakopane, Poland

open access

Vol 92, No 6 (2021)
REVIEW PAPERS Obstetrics
Published online: 2021-04-29

Abstract

Vitamin D3 (VD3) and its steroidal nuclear receptor are necessary for proper development of a pregnancy. They play a key role in implantation, modulate the mother’s immune response to the developing fetus, influence the final development of a placenta, and regulate blood pressure and glucose tolerance. VD3 deficiency can lead to the occurrence of obstetric complications such as recurrent miscarriages, preeclampsia, intrauterine growth restriction, gestational diabetes and preterm labor. VD3 deficiency is a common phenomenon across the globe; because of the higher demand placed on their bodies, pregnant women are more likely to develop VD3 deficiency. During pregnancy, VD3 supplementation is a safe method of treatment without risk of side effects or intoxication. To obtain the greatest efficacy, VD3 supplementation should start at the pregnancy planning stage, under control of the VD3 serum concentration, which should exceed 30 ng/mL (75 nmol/L); this is to start the positive effect of the optimal VD3 concentration from the beginning of a pregnancy.

Abstract

Vitamin D3 (VD3) and its steroidal nuclear receptor are necessary for proper development of a pregnancy. They play a key role in implantation, modulate the mother’s immune response to the developing fetus, influence the final development of a placenta, and regulate blood pressure and glucose tolerance. VD3 deficiency can lead to the occurrence of obstetric complications such as recurrent miscarriages, preeclampsia, intrauterine growth restriction, gestational diabetes and preterm labor. VD3 deficiency is a common phenomenon across the globe; because of the higher demand placed on their bodies, pregnant women are more likely to develop VD3 deficiency. During pregnancy, VD3 supplementation is a safe method of treatment without risk of side effects or intoxication. To obtain the greatest efficacy, VD3 supplementation should start at the pregnancy planning stage, under control of the VD3 serum concentration, which should exceed 30 ng/mL (75 nmol/L); this is to start the positive effect of the optimal VD3 concentration from the beginning of a pregnancy.

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Keywords

vitamin D; VDR; pregnancy complications

About this article
Title

Vitamin D3 and its receptor in selected obstetrical complications

Journal

Ginekologia Polska

Issue

Vol 92, No 6 (2021)

Article type

Review paper

Pages

460-465

Published online

2021-04-29

Page views

922

Article views/downloads

741

DOI

10.5603/GP.a2021.0088

Pubmed

33914313

Bibliographic record

Ginekol Pol 2021;92(6):460-465.

Keywords

vitamin D
VDR
pregnancy complications

Authors

Justyna Magielda-Stola
Krzysztof Drews
Hubert Wolski
Agnieszka Seremak-Mrozikiewicz

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