open access

Vol 92, No 8 (2021)
Research paper
Published online: 2021-04-06
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Correlation of monocyte/HDL ratio (MHR) with inflammatory parameters in obese patients diagnosed with polycystic ovary syndrome

Dilsad Herkiloglu1, Sefik Gokce1
DOI: 10.5603/GP.a2020.0191
·
Pubmed: 33844250
·
Ginekol Pol 2021;92(8):537-543.
Affiliations
  1. Istanbul Yeni Yuzyil University Department Of Obstetrics And Gynecology, Istanbul, Turkey

open access

Vol 92, No 8 (2021)
ORIGINAL PAPERS Gynecology
Published online: 2021-04-06

Abstract

Objectives: Monocyte/high density lipprotein (HDL) ratio (MHR) has been reported to be associated with obesity and polycystic ovarian syndrome (PCOS). In this study, it was aimed to evaluate whether there is a relationship between PCOS and MHR and inflammatory parameters, to investigate the relationship level of MHR and lymphocyte/monocyte ratio (LMR), which are easily accessible inflammatory and oxidative stress markers, with obese women with PCOS, and to determine the usability of MHR as a predictive marker for PCOS.
Material and methods: The study included 64 PCOS-patients who were admitted to Gynecology clinics and 52 healthy women.
Results: The mean MHR (12.5 ± 4.6) in the PCOS group was significantly higher than the control group (10.4 ± 4.0) (p = 0.01). In the examination performed by combining the groups PCOS and obesity status, the mean MHR value in the PCOS-obese group was significantly higher than all the other groups (p = 0.004). In the ROC analysis, the threshold value of 10.1 for MHR was found to have a sensitivity of 84.8% and specificity of 58.5% in determining the association between PCOS and obesity (AUC: 0.721; p < 0.001; LB: 0.628; UB: 0.814; CI 95%). Accordingly, the rate of those with MHR level of 10.1 and above was significantly higher in the PCOS group compared to the control group (67.2% vs 40.4%) (p = 0.001). In the logistic regression analysis, the determination is increased by 3,026 times (odds ratio; 1.401–6.535) in predicting the presence of PCOS in those with MHR value of 10.1 and above, and 7,576 times (Odds ratio; 2.652–21.646) in predicting the presence of PCOS + obesity was found to be. Correlation analysis in PCOS patients revealed that the MHR value was negatively correlated with age (p = 0.001; r = –0.412), LMR (p = 0.003; r = –0.377), and total cholesterol [p = 0.018; correlation coefficient (r) = –0.302].
Conclusions: This study findings showed that MHR level is significantly related to PCOS, and especially MHR values above 10.1 may be a significant predictive marker for PCOS. Our study findings also show that an association of PCOS and obesity is a very important trigger on MHR.

Abstract

Objectives: Monocyte/high density lipprotein (HDL) ratio (MHR) has been reported to be associated with obesity and polycystic ovarian syndrome (PCOS). In this study, it was aimed to evaluate whether there is a relationship between PCOS and MHR and inflammatory parameters, to investigate the relationship level of MHR and lymphocyte/monocyte ratio (LMR), which are easily accessible inflammatory and oxidative stress markers, with obese women with PCOS, and to determine the usability of MHR as a predictive marker for PCOS.
Material and methods: The study included 64 PCOS-patients who were admitted to Gynecology clinics and 52 healthy women.
Results: The mean MHR (12.5 ± 4.6) in the PCOS group was significantly higher than the control group (10.4 ± 4.0) (p = 0.01). In the examination performed by combining the groups PCOS and obesity status, the mean MHR value in the PCOS-obese group was significantly higher than all the other groups (p = 0.004). In the ROC analysis, the threshold value of 10.1 for MHR was found to have a sensitivity of 84.8% and specificity of 58.5% in determining the association between PCOS and obesity (AUC: 0.721; p < 0.001; LB: 0.628; UB: 0.814; CI 95%). Accordingly, the rate of those with MHR level of 10.1 and above was significantly higher in the PCOS group compared to the control group (67.2% vs 40.4%) (p = 0.001). In the logistic regression analysis, the determination is increased by 3,026 times (odds ratio; 1.401–6.535) in predicting the presence of PCOS in those with MHR value of 10.1 and above, and 7,576 times (Odds ratio; 2.652–21.646) in predicting the presence of PCOS + obesity was found to be. Correlation analysis in PCOS patients revealed that the MHR value was negatively correlated with age (p = 0.001; r = –0.412), LMR (p = 0.003; r = –0.377), and total cholesterol [p = 0.018; correlation coefficient (r) = –0.302].
Conclusions: This study findings showed that MHR level is significantly related to PCOS, and especially MHR values above 10.1 may be a significant predictive marker for PCOS. Our study findings also show that an association of PCOS and obesity is a very important trigger on MHR.

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Keywords

monocyte/HDL ratio; PCOS; obesity

About this article
Title

Correlation of monocyte/HDL ratio (MHR) with inflammatory parameters in obese patients diagnosed with polycystic ovary syndrome

Journal

Ginekologia Polska

Issue

Vol 92, No 8 (2021)

Article type

Research paper

Pages

537-543

Published online

2021-04-06

DOI

10.5603/GP.a2020.0191

Pubmed

33844250

Bibliographic record

Ginekol Pol 2021;92(8):537-543.

Keywords

monocyte/HDL ratio
PCOS
obesity

Authors

Dilsad Herkiloglu
Sefik Gokce

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