open access

Vol 92, No 9 (2021)
Research paper
Published online: 2021-04-08
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Maternal serum IL-22 concentrations are significantly upregulated in patients with preterm premature rupture of membranes

Mustafa Behram1, Süleyman Cemil Oğlak2, Yusuf Başkıran1, Sema Süzen Çaypınar1, Sedat Akgöl1, Şeyhmus Tunç2, Zeynep Gedik Özköse1, Emrullah Akay3, Ismail Dağ4
DOI: 10.5603/GP.a2021.0036
·
Pubmed: 33844260
·
Ginekol Pol 2021;92(9):631-636.
Affiliations
  1. Department of Obstetrics and Gynecology, Health Sciences University, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey
  2. Department of Obstetrics and Gynecology, Health Sciences University, Gazi Yaşargil Training and Research Hospital, Diyarbakır, Turkey
  3. Department of Obstetrics and Gynecology, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey
  4. Department of Biochemistry, Eyüpsultan State Hospital, Istanbul, Turkey

open access

Vol 92, No 9 (2021)
ORIGINAL PAPERS Obstetrics
Published online: 2021-04-08

Abstract

Objectives: This study aimed to compare the serum IL-22 levels between preterm premature rupture of membranes (PPROM) patients and the control group with intact membranes. We also hypothesized whether serum IL-22 upregulation might contribute to defense against inflammatory responses and improve the pregnancy outcomes.
Material and methods: We performed this prospective case-control study between 24–34 weeks of pregnancy. We enrolled 40 singleton pregnant patients with PPROM and 40 healthy gestational age- and gravidity-matched patients without PPROM. The degree of association between variables and IL-22 were calculated by Spearman correlation coefficients where appropriate. Scatter plots were given for statistically significant correlations. ROC curve was constructed to illustrate the sensitivity and specificity performance characteristics of IL-22, and a cutoff value was estimated by using the index of Youden.
Results: Maternal serum IL-22 levels were significantly higher in PPROM patients (60.34 ± 139.81 pg/mL) compared to the participants in the control group (20.71 ± 4.36 pg/mL, p < 0.001). When we analyze the area under the ROC curve (AUC), the IL-22 value can be considered a statistically significant parameter for diagnosing PPROM. According to the Youden index, a 23.86 pg/mL cut-off value of IL-22 can be used to diagnosing PPROM with 72% sensitivity and 61.5% specificity. There was no positive correlation between serum IL-22 levels and maternal C-reactive protein (CRP) value, procalcitonin value, latency period, birth week, birth weight, and umbilical cord blood pH value.
Conclusions: Maternal serum IL-22 levels were significantly higher in PPROM patients than healthy pregnant women with an intact membrane. We suggest that IL-22 might be a crucial biomarker of the inflammatory process in PPROM.

Abstract

Objectives: This study aimed to compare the serum IL-22 levels between preterm premature rupture of membranes (PPROM) patients and the control group with intact membranes. We also hypothesized whether serum IL-22 upregulation might contribute to defense against inflammatory responses and improve the pregnancy outcomes.
Material and methods: We performed this prospective case-control study between 24–34 weeks of pregnancy. We enrolled 40 singleton pregnant patients with PPROM and 40 healthy gestational age- and gravidity-matched patients without PPROM. The degree of association between variables and IL-22 were calculated by Spearman correlation coefficients where appropriate. Scatter plots were given for statistically significant correlations. ROC curve was constructed to illustrate the sensitivity and specificity performance characteristics of IL-22, and a cutoff value was estimated by using the index of Youden.
Results: Maternal serum IL-22 levels were significantly higher in PPROM patients (60.34 ± 139.81 pg/mL) compared to the participants in the control group (20.71 ± 4.36 pg/mL, p < 0.001). When we analyze the area under the ROC curve (AUC), the IL-22 value can be considered a statistically significant parameter for diagnosing PPROM. According to the Youden index, a 23.86 pg/mL cut-off value of IL-22 can be used to diagnosing PPROM with 72% sensitivity and 61.5% specificity. There was no positive correlation between serum IL-22 levels and maternal C-reactive protein (CRP) value, procalcitonin value, latency period, birth week, birth weight, and umbilical cord blood pH value.
Conclusions: Maternal serum IL-22 levels were significantly higher in PPROM patients than healthy pregnant women with an intact membrane. We suggest that IL-22 might be a crucial biomarker of the inflammatory process in PPROM.

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Keywords

preterm premature rupture of membranes; interleukin-22; neonatal outcomes

About this article
Title

Maternal serum IL-22 concentrations are significantly upregulated in patients with preterm premature rupture of membranes

Journal

Ginekologia Polska

Issue

Vol 92, No 9 (2021)

Article type

Research paper

Pages

631-636

Published online

2021-04-08

DOI

10.5603/GP.a2021.0036

Pubmed

33844260

Bibliographic record

Ginekol Pol 2021;92(9):631-636.

Keywords

preterm premature rupture of membranes
interleukin-22
neonatal outcomes

Authors

Mustafa Behram
Süleyman Cemil Oğlak
Yusuf Başkıran
Sema Süzen Çaypınar
Sedat Akgöl
Şeyhmus Tunç
Zeynep Gedik Özköse
Emrullah Akay
Ismail Dağ

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