open access

Vol 92, No 6 (2021)
Research paper
Published online: 2021-03-10
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Vaginal dinoprostone and misoprostol are equally safe in labour induction at term whereas dinoprostone is less efficacious for cervical ripening and shortening the time of labour

Maciej Zietek1, Malgorzata Swiatkowska-Freud2, Kinga Grajnert1, Zbigniew Celewicz1, Malgorzata Szczuko3
DOI: 10.5603/GP.a2021.0189
·
Ginekol Pol 2021;92(6):428-435.
Affiliations
  1. Department of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland
  2. Department of Obstetrics, Medical University in Gdansk, Poland
  3. Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, Poland

open access

Vol 92, No 6 (2021)
ORIGINAL PAPERS Obstetrics
Published online: 2021-03-10

Abstract

Objectives: The aims of the study is to analyze the effectiveness and safety of the use of intravaginal inserts with prostaglandin analogues: dinoprostone and misoprostol, in the labor induction.
Material and methods: Pregnant women (177), with use of dinoprostone (n = 69) or misoprostol (n = 108) for labor induction were analyzed.
Results: The length of time of delivery differed significantly between primiparous and multiparous women and depended on the type of prostaglandin. The incidence of cesarean sections did not differ significantly in analysed groups. The risk of failed induction was over two-fold higher in the dinoprostone group as compared to misoprostol. A statistically significant longer duration of the first and second stage of labor was observed in primiparous compared to multiparous women as well as differences of cervical ripening were observed. There was no statistically significant relationship between the occurrence of hyperstimulation and worsening the newborns condition determined after delivery.
Conclusions: Vaginal dinoprostone and misoprostol are equally safe in labor induction at term whereas dinoprostone is less efficacious for cervical ripening and shortening the time of labor. There was no advantage of any of the prostaglandins used in increasing the risk of having a child in a worse condition and increasing the percentage of caesarean sections.

Abstract

Objectives: The aims of the study is to analyze the effectiveness and safety of the use of intravaginal inserts with prostaglandin analogues: dinoprostone and misoprostol, in the labor induction.
Material and methods: Pregnant women (177), with use of dinoprostone (n = 69) or misoprostol (n = 108) for labor induction were analyzed.
Results: The length of time of delivery differed significantly between primiparous and multiparous women and depended on the type of prostaglandin. The incidence of cesarean sections did not differ significantly in analysed groups. The risk of failed induction was over two-fold higher in the dinoprostone group as compared to misoprostol. A statistically significant longer duration of the first and second stage of labor was observed in primiparous compared to multiparous women as well as differences of cervical ripening were observed. There was no statistically significant relationship between the occurrence of hyperstimulation and worsening the newborns condition determined after delivery.
Conclusions: Vaginal dinoprostone and misoprostol are equally safe in labor induction at term whereas dinoprostone is less efficacious for cervical ripening and shortening the time of labor. There was no advantage of any of the prostaglandins used in increasing the risk of having a child in a worse condition and increasing the percentage of caesarean sections.

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Keywords

dinoprostone; misoprostol; labor induction

About this article
Title

Vaginal dinoprostone and misoprostol are equally safe in labour induction at term whereas dinoprostone is less efficacious for cervical ripening and shortening the time of labour

Journal

Ginekologia Polska

Issue

Vol 92, No 6 (2021)

Article type

Research paper

Pages

428-435

Published online

2021-03-10

DOI

10.5603/GP.a2021.0189

Bibliographic record

Ginekol Pol 2021;92(6):428-435.

Keywords

dinoprostone
misoprostol
labor induction

Authors

Maciej Zietek
Malgorzata Swiatkowska-Freud
Kinga Grajnert
Zbigniew Celewicz
Malgorzata Szczuko

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