Assisted reproductive medicine in Poland, 2013–2016: Polish Society of Reproductive Medicine and Embryology (PTMRiE) and Fertility and Sterility Special Interest Group of the Polish Society of Gynaecologists and Obstetricians (SPiN PTGiP) report
Abstract
Objectives: The purpose of this publication is to present data on the results and complications associated with infertility
treatment using assisted reproductive technology (ART) and intrauterine insemination (IUI) in Poland between 2013 and 2016.
Material and methods: The report was prepared by the Polish Society of Reproductive Medicine and Embryology (PTMRiE)
and the Fertility and Sterility Special Interest Group of the Polish Society of Gynaecologists and Obstetrics (SPiN PTGiP) as
a part of the European IVF Monitoring program (EIM) for the European Society of Human Reproduction and Embryology
(ESHRE). Reporting was voluntary and the data was not subject to external control. The report presents the availability and
structure of infertility treatment services, the number of procedures, their effectiveness and complications.
Results: Between 2013 and 2016, a total of 106,718 treatment cycles using ART [64,413 classical in vitro fertilization and
in vitro fertilization with intracytoplasmic sperm injection (IVF + ICSI), 36,041 frozen embryo replacements (FER)] and
51,405 IUI were recorded. The clinical pregnancy rates per embryo transfer in IVF, ICSI and FER were 38.3%, 38.1% and 32.4%,
respectively. The effectiveness of IUI with husband/partner’s semen (IUI-H) was 11.1% and with donor semen (IUI-D) 16.7%.
Multiple delivery rates were 11.3% and 6.2% in IVF + ICSI and IUI, respectively. The most common complication was the
ovarian hyperstimulation syndrome (OHSS) (0.34%).
Conclusions: PTMRiE and SPiN PTGiP report is the only national study documenting Polish reproductive medicine. The
results of infertility treatment effectiveness in Poland are comparable with the European data, complications are less frequent
than in other countries. The low percentage of multiple pregnancies, and so perinatal complications, is especially
valuable. However, due to the lack of a central database and register, the possibility of external control and monitoring of
pregnancies and births is limited. Thus, a fully reliable assessment of the treatment quality in our country is not possible.
Keywords: PTMRiE and SPiN PTGiP reportinfertility treatmentassisted reproduction techniquesIVFICSIIUI
References
- programme TEm. Assisted reproductive technology in Europe, 1997. Results generated from European registers by ESHRE. Hum Reprod. 2001; 16(2): 384–391.
- Nygren KG, Andersen AN. European IVF-monitoring programme (EIM). Assisted reproductive technology in Europe, 1998. Results generated from European registers by ESHRE. European Society of Human Reproduction and Embryology. Hum Reprod. 2001; 16(11): 2459–2471.
- Nygren KG, Andersen AN. Assisted reproductive technology in Europe, 1999. Results generated from European registers by ESHRE. Hum Reprod. 2002; 17(12): 3260–3274.
- Nyboe Andersen A, Gianaroli L, Nygren KG, et al. European IVF-monitoring programme, European Society of Human Reproduction and Embryology. Assisted reproductive technology in Europe, 2000. Results generated from European registers by ESHRE. Hum Reprod. 2004; 19(3): 490–503.
- Andersen NA, Gianaroli L, Felberbaum R, et al. Assisted reproductive technology in Europe, 2001. Results generated from European registers by ESHRE. Hum Reprod. 2005; 20(5): 1158–1176.
- Andersen AN, Gianaroli L, Felberbaum R, et al. Assisted reproductive technology in Europe, 2002. Results generated from European registers by ESHRE. Hum Reprod. 2006; 21(7): 1680–1697.
- Andersen AN, Goossens V, Gianaroli L, et al. Assisted reproductive technology in Europe, 2003. Results generated from European registers by ESHRE. Hum Reprod. 2007; 22(6): 1513–1525.
- Andersen AN, Goossens V, Ferraretti AP, et al. European IVF-monitoring (EIM) Consortium, European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2004: results generated from European registers by ESHRE. Hum Reprod. 2008; 23(4): 756–771.
- Nyboe Andersen A, Goossens V, Bhattacharya S, et al. European IVF-monitoring (EIM) Consortium, for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology and intrauterine inseminations in Europe, 2005: results generated from European registers by ESHRE: ESHRE. The European IVF Monitoring Programme (EIM), for the European Society of Human Reproduction and Embryology (ESHRE). Hum Reprod. 2009; 24(6): 1267–1287.
- de Mouzon J, Goossens V, Bhattacharya S, et al. European IVF-monitoring (EIM) Consortium, for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE. Hum Reprod. 2010; 25(8): 1851–1862.
- Mouzon Jde, Goossens V, Bhattacharya S, et al. Assisted reproductive technology in Europe, 2007: results generated from European registers by ESHRE. Hum Reprod. 2012; 27(4): 954–966.
- Ferraretti AP, Goossens V, Mouzon Jde, et al. Assisted reproductive technology in Europe, 2008: results generated from European registers by ESHRE†. Hum Reprod. 2012; 27(9): 2571–2584.
- Ferraretti AP, Goossens V, Kupka M, et al. Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE†. Hum Reprod. 2013; 28(9): 2318–2331.
- Kupka MS, Ferraretti AP, de Mo, et al. Assisted reproductive technology in Europe, 2010: results generated from European registers by ESHRE. Hum Reprod. 2014; 29(10): 2099–2113.
- Kupka MS, D'Hooghe T, Ferraretti AP, et al. European IVF-Monitoring Consortium (EIM), European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2011: results generated from European registers by ESHRE. Hum Reprod. 2016; 31(2): 233–248.
- Calhaz-Jorge C, De Geyter C, Kupka MS, et al. European IVF-monitoring Consortium (EIM), European Society of Human Reproduction and Embryology (ESHRE), European IVF-Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHRE. Hum Reprod. 2016; 31(8): 1638–1652.
- De Geyter Ch, Calhaz-Jorge C, Kupka MS, et al. European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE), European IVF-monitoring Consortium (EIM), European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2013: results generated from European registers by ESHRE. Hum Reprod. 2017; 32(10): 1957–1973.
- Geyter ChDe, Calhaz-Jorge C, Kupka MS, et al. ART in Europe, 2014: results generated from European registries by ESHRE†. Hum Reprod. 2018; 33(9): 1586–1601.
- De Geyter C, Calhaz-Jorge C, Kupka MS, et al. European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE), European IVF-monitoring Consortium (EIM)‡ for the European Society of Human Reproduction and Embryology (ESHRE) , European IVF-monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE) . ART in Europe, 2015: results generated from European registries by ESHRE. Hum Reprod Open. 2020; 2020(1): hoz038.
- Program – Leczenie Niepłodności Metodą Zapłodnienia Pozaustrojowego na lata 2013 – 2016. Ministerstwo Zdrowia, Warszawa 2013.
- Ustawa z dnia 25 czerwca 2015 roku o leczeniu niepłodności – The Act on infertility treatment (Dz.U. 2015 poz. 1087).
- https://roib.rejestrymedyczne.csioz.gov.pl/.
- Janicka A, Spaczyńiski RZ, Kurzawa R, et al. SPiN PTG, Fertility Clinics, Polish Gynaecological Society. Assisted reproductive medicine in Poland --Fertility and Sterility Special Interest Group of the Polish Gynaecological Society (SPiN PTG) 2012 report. Ginekol Pol. 2015; 86(12): 932–939.
- Zegers-Hochschild F, Adamson G, Dyer S, et al. The International Glossary on Infertility and Fertility Care, 2017†‡§. Hum Reprod. 2017; 32(9): 1786–1801.
- Janicka A, Spaczyński RZ, Kurzawa R. [Assisted reproductive medicine in Poland, 2011--SPiN PTG report]. Ginekol Pol. 2014; 85(7): 549–556.
- Rocznik demograficzny 2017. Główny Urząd Statystyczny, Warszawa 2017.
- ESHRE Capri Workshop Group. Social determinants of human reproduction. Hum Reprod. 2001; 16(7): 1518–1526.
- McLernon DJ, Harrild K, Bergh C, et al. Clinical effectiveness of elective single versus double embryo transfer: meta-analysis of individual patient data from randomised trials. BMJ. 2010; 341: c6945.
- Gelbaya TA, Tsoumpou I, Nardo LG. The likelihood of live birth and multiple birth after single versus double embryo transfer at the cleavage stage: a systematic review and meta-analysis. Fertil Steril. 2010; 94(3): 936–945.