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Vol 92, No 1 (2021)
Research paper
Published online: 2020-11-19
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The analysis of the prognostic value of the neutrophil/ lymphocyte ratio and the platelet/lymphocyte ratio among advanced endometrial cancer patients

Konrad Piotr Muzykiewicz1, Ewa Iwanska1, Maja Janeczek2, Izabela Glanowska1, Kaziemierz Karolewski1, Pawel Blecharz3
DOI: 10.5603/GP.a2020.0164
·
Pubmed: 33448001
·
Ginekol Pol 2021;92(1):16-23.
Affiliations
  1. Department of Gynaecologic Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Cracow Branch, Poland, Poland
  2. Department of Gynaecology and Obstetrics, Stefan Zeromski Memorial Specialist City Hospital, Cracow, Poland
  3. St. John’s Cancer Centre in Lublin, Lublin, Poland

open access

Vol 92, No 1 (2021)
ORIGINAL PAPERS Gynecology
Published online: 2020-11-19

Abstract

Objectives: About 20% of endometrial cancer (EC) patients have advanced disease (FIGO III & IV) at the moment of diagnosis.
An attempt to evaluate the prognostic value of biochemical markers of inflammation and classic endometrial cancer
prognostic factors in the group of advanced EC (aEC) patients has been made in this study.
Material and methods: Records of 266 patients treated in the Maria Sklodowska-Curie Memorial Cancer Centre and Institute
of Oncology, Cracow Branch between the year 2006 and 2018 were included in the study. Follow-up ranged from 1 to
138 months. Progression free survival (PFS) and overall survival (OS) have been set as endpoints. Tests such as: chi-squared,
Fisher, log-rank, Mann-Whitney, Kruskal-Wallis and Cox proportional hazard ratio were used in the statistical analyses.
Results: In the analysed group high total platelet count (PLT) before operative treatment and high levels of white blood cells
(WBC), PLT, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) before adjuvant therapy (AT) have been
significantly associated with shorter PFS and OS. After setting the cut-off values of NLR and PLR a statistically significant
correlation between those parameters and PFS as well as OS has been shown. Multivariate analysis has indicated that NLR
is an independent prognostic factor of the course of aEC.
Conclusions: NLR and PLR correlate significantly with OS and PFS in aEC. NLR is an independent prognostic factor in this
group. It is possible to distinguish 3 risk groups, among aEC patients, based on NRL and PLR.

Abstract

Objectives: About 20% of endometrial cancer (EC) patients have advanced disease (FIGO III & IV) at the moment of diagnosis.
An attempt to evaluate the prognostic value of biochemical markers of inflammation and classic endometrial cancer
prognostic factors in the group of advanced EC (aEC) patients has been made in this study.
Material and methods: Records of 266 patients treated in the Maria Sklodowska-Curie Memorial Cancer Centre and Institute
of Oncology, Cracow Branch between the year 2006 and 2018 were included in the study. Follow-up ranged from 1 to
138 months. Progression free survival (PFS) and overall survival (OS) have been set as endpoints. Tests such as: chi-squared,
Fisher, log-rank, Mann-Whitney, Kruskal-Wallis and Cox proportional hazard ratio were used in the statistical analyses.
Results: In the analysed group high total platelet count (PLT) before operative treatment and high levels of white blood cells
(WBC), PLT, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) before adjuvant therapy (AT) have been
significantly associated with shorter PFS and OS. After setting the cut-off values of NLR and PLR a statistically significant
correlation between those parameters and PFS as well as OS has been shown. Multivariate analysis has indicated that NLR
is an independent prognostic factor of the course of aEC.
Conclusions: NLR and PLR correlate significantly with OS and PFS in aEC. NLR is an independent prognostic factor in this
group. It is possible to distinguish 3 risk groups, among aEC patients, based on NRL and PLR.

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Keywords

advanced endometrial cancer; NLR; PLR; adjuvant treatment

About this article
Title

The analysis of the prognostic value of the neutrophil/ lymphocyte ratio and the platelet/lymphocyte ratio among advanced endometrial cancer patients

Journal

Ginekologia Polska

Issue

Vol 92, No 1 (2021)

Article type

Research paper

Pages

16-23

Published online

2020-11-19

Page views

1072

Article views/downloads

1054

DOI

10.5603/GP.a2020.0164

Pubmed

33448001

Bibliographic record

Ginekol Pol 2021;92(1):16-23.

Keywords

advanced endometrial cancer
NLR
PLR
adjuvant treatment

Authors

Konrad Piotr Muzykiewicz
Ewa Iwanska
Maja Janeczek
Izabela Glanowska
Kaziemierz Karolewski
Pawel Blecharz

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