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Research paper
Published online: 2021-04-22
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Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism

Fatma Beyazit1, Merve Meliha Hiz2, Hakan Turkon3, Mesut Abdulkerim Unsal1
DOI: 10.5603/GP.a2020.0176
·
Pubmed: 33914321
Affiliations
  1. Department of Obstetrics and Gynecology, Faculty of Medicine, Canakkale Onsekiz Mart University, Canakkale, Turkey
  2. Department of Medical Biology, Faculty of Medicine, Canakkale Onsekiz Mart University, Çanakkale, Turkey
  3. Department of Biochemistry, Meddem Hospital, Isparta, Turkey

open access

Ahead of Print
ORIGINAL PAPERS Gynecology
Published online: 2021-04-22

Abstract

Objectives: Polycystic ovary syndrome (PCOS) is a complex reproductive endocrinopathy among reproductive-aged women and related with body mass and insulin resistance. Adipocytokines produced by adipose tissue seems to take part in the hormonal and metabolic alterations that arise in PCOS. Fat mass and obesity associated (FTO) gene is linked with body mass index (BMI) and diabetes.
Aims — To investigate the association between fat mass related adipocytokines and single nucleotide polymorphisms (SNPs) (rs9939609 T/A) in the FTO gene in women with PCOS.
Material and methods: FTO+rs9939609 gene polymorphism and serum spexin, adiponectin and leptin levels were deter-mined in 91 PCOS women and 86 healthy controls. Study participants were subdivided according to BMI and comparisons were made within each group.
Results: Serum spexin levels were not differed between study groups. Serum levels of adiponectin were found to be de-creased in PCOS women with BMI lower than 25 kg/m2 (10.1 ± 5.6 vs 14.1 ± 9.1, p = 0.015). Serum leptin levels were elevated in obese PCOS women compared to healthy control group (2197.9 ± 596.3 pg/mL vs 1535.9 ± 812.1 pg/mL, p = 0.001). The prevalence of A risk allele of SNP rs9939609 was more frequent in PCOS patients than in the control group. PCOS risk was found to increase 3 times more in AA genotype when compared with TT genotype (OR = 3.04 95% CI: 1.243–7.309; p = 0.013).
Conclusions: Serum adiponectin and leptin levels may serve as independent markers for PCOS diagnosis. Moreover, the FTO+rs9939609 gene polymorphism increase susceptibility to PCOS development independent from serum adipocytokine levels.

Abstract

Objectives: Polycystic ovary syndrome (PCOS) is a complex reproductive endocrinopathy among reproductive-aged women and related with body mass and insulin resistance. Adipocytokines produced by adipose tissue seems to take part in the hormonal and metabolic alterations that arise in PCOS. Fat mass and obesity associated (FTO) gene is linked with body mass index (BMI) and diabetes.
Aims — To investigate the association between fat mass related adipocytokines and single nucleotide polymorphisms (SNPs) (rs9939609 T/A) in the FTO gene in women with PCOS.
Material and methods: FTO+rs9939609 gene polymorphism and serum spexin, adiponectin and leptin levels were deter-mined in 91 PCOS women and 86 healthy controls. Study participants were subdivided according to BMI and comparisons were made within each group.
Results: Serum spexin levels were not differed between study groups. Serum levels of adiponectin were found to be de-creased in PCOS women with BMI lower than 25 kg/m2 (10.1 ± 5.6 vs 14.1 ± 9.1, p = 0.015). Serum leptin levels were elevated in obese PCOS women compared to healthy control group (2197.9 ± 596.3 pg/mL vs 1535.9 ± 812.1 pg/mL, p = 0.001). The prevalence of A risk allele of SNP rs9939609 was more frequent in PCOS patients than in the control group. PCOS risk was found to increase 3 times more in AA genotype when compared with TT genotype (OR = 3.04 95% CI: 1.243–7.309; p = 0.013).
Conclusions: Serum adiponectin and leptin levels may serve as independent markers for PCOS diagnosis. Moreover, the FTO+rs9939609 gene polymorphism increase susceptibility to PCOS development independent from serum adipocytokine levels.

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Keywords

PCOS; FTO gene polymorphism; spexin; adiponectin; leptin

About this article
Title

Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism

Journal

Ginekologia Polska

Issue

Ahead of Print

Article type

Research paper

Published online

2021-04-22

DOI

10.5603/GP.a2020.0176

Pubmed

33914321

Keywords

PCOS
FTO gene polymorphism
spexin
adiponectin
leptin

Authors

Fatma Beyazit
Merve Meliha Hiz
Hakan Turkon
Mesut Abdulkerim Unsal

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