open access

Vol 92, No 5 (2021)
Research paper
Published online: 2021-03-05
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Pregnancy outcomes in different stages of systemic lupus erythematosus among Chinese women — a retrospective cohort study

Yaping Lu1, Yinghua Yu2, Weilan Xia3, Diwen Chen3, Xingmei Wu3, Tingting Cheng3
DOI: 10.5603/GP.a2020.0151
·
Pubmed: 33751514
·
Ginekol Pol 2021;92(5):365-370.
Affiliations
  1. Department of Obstetrics and Gynecology, Maternal and Child Health Care of Shandong Province, Jinan, China
  2. Department of Obstetrics and Gynecology, Zhongda Hospital Lishui Branch, affiliated to Southeast University, Nanjing, China
  3. Department of Obstetrics and Gynecology, Lishui People’s Hospital, affiliated Hospital 6 to Wenzhou Medical University, Lishui, China

open access

Vol 92, No 5 (2021)
ORIGINAL PAPERS Obstetrics
Published online: 2021-03-05

Abstract

Objectives: To analyze the outcomes of pregnancies and risk factors in Chinese women with different stages of systemic lupus erythematosus (SLE).
Material and methods: A total of 55 conceptions in 52 patients with SLE between Jan 2007 and Jan 2019 were retrospected systematically from a general hospital graded 3A in China. Medical records provided us a good way to retrieve the clinical parameters and lab data of patients.
Results: Pregnant women with SLE activity had significant hyperimmunoglobulin, hypocomplement, low platelet counts, high erythrocyte sedimentation rate, C-reactive protein and 24-h urine protein. Hydroxychloroquine had been used to reduce the rates of SLE activity in pregnant women. Logistic regression analysis showed low platelet counts, hypocomplement and 24-h urine protein were significantly correlated with fetal loss. Compared to those in stable stage, the active SLE patients have more risks of hypertensive disorders of pregnancy, thrombocytopenia, lupus nephritis and placental infarction, and have worse fetal outcomes, including the higher rate of fetal loss, preterm and asphyxia neonatorum.
Conclusions: Different stages of SLE during pregnancy are closely related to maternal and fetal outcomes. It is imperative to provide SLE women with pregnancy consultation and regular multispecialty care.

Abstract

Objectives: To analyze the outcomes of pregnancies and risk factors in Chinese women with different stages of systemic lupus erythematosus (SLE).
Material and methods: A total of 55 conceptions in 52 patients with SLE between Jan 2007 and Jan 2019 were retrospected systematically from a general hospital graded 3A in China. Medical records provided us a good way to retrieve the clinical parameters and lab data of patients.
Results: Pregnant women with SLE activity had significant hyperimmunoglobulin, hypocomplement, low platelet counts, high erythrocyte sedimentation rate, C-reactive protein and 24-h urine protein. Hydroxychloroquine had been used to reduce the rates of SLE activity in pregnant women. Logistic regression analysis showed low platelet counts, hypocomplement and 24-h urine protein were significantly correlated with fetal loss. Compared to those in stable stage, the active SLE patients have more risks of hypertensive disorders of pregnancy, thrombocytopenia, lupus nephritis and placental infarction, and have worse fetal outcomes, including the higher rate of fetal loss, preterm and asphyxia neonatorum.
Conclusions: Different stages of SLE during pregnancy are closely related to maternal and fetal outcomes. It is imperative to provide SLE women with pregnancy consultation and regular multispecialty care.

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Keywords

systemic lupus erythematosus; clinical parameters; lab data; maternal outcome; fetal outcome

About this article
Title

Pregnancy outcomes in different stages of systemic lupus erythematosus among Chinese women — a retrospective cohort study

Journal

Ginekologia Polska

Issue

Vol 92, No 5 (2021)

Article type

Research paper

Pages

365-370

Published online

2021-03-05

DOI

10.5603/GP.a2020.0151

Pubmed

33751514

Bibliographic record

Ginekol Pol 2021;92(5):365-370.

Keywords

systemic lupus erythematosus
clinical parameters
lab data
maternal outcome
fetal outcome

Authors

Yaping Lu
Yinghua Yu
Weilan Xia
Diwen Chen
Xingmei Wu
Tingting Cheng

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