open access

Vol 92, No 4 (2021)
Review paper
Published online: 2021-03-12
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Contemporary principles of diagnostic and therapeutic management in cervical and ovarian neuroendocrine tumors

Mariusz Bidzinski1, Szymon Piatek1, Jaroslaw Cwikla2, Anna Nasierowska-Guttmejer34, Anna Danska-Bidzinska5
DOI: 10.5603/GP.a2020.0189
·
Pubmed: 33751517
·
Ginekol Pol 2021;92(4):312-317.
Affiliations
  1. Department of Gynecologic Oncology, Maria Sklodowska-Curie National Research Institute of Oncology Warsaw, Poland
  2. Department of Radiology, University of Warmia and Mazury, Olsztyn, Poland
  3. Pathology Department, Central Clinical Hospital of the MSWiA, Warsaw, Poland
  4. Institute of Outcomes Research, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland
  5. 2-nd Clinic of Obstetrics and Gynecology, Medical University of Warsaw, Poland

open access

Vol 92, No 4 (2021)
REVIEW PAPERS Gynecology
Published online: 2021-03-12

Abstract

Enhancing knowledge about neuroendocrine neoplasms causes the need to improve management of these tumors. Although
these tumors are rare in clinical practice, their biological diversity makes both diagnostics and therapy a challenge
for contemporary oncology. The article discusses the latest developments in the diagnostic procedures and methods of
treatment of the cervical and ovarian neuroendocrine tumors. Algorithms are presented to understand the differences in
therapeutic management in these malignancies.

Abstract

Enhancing knowledge about neuroendocrine neoplasms causes the need to improve management of these tumors. Although
these tumors are rare in clinical practice, their biological diversity makes both diagnostics and therapy a challenge
for contemporary oncology. The article discusses the latest developments in the diagnostic procedures and methods of
treatment of the cervical and ovarian neuroendocrine tumors. Algorithms are presented to understand the differences in
therapeutic management in these malignancies.

Get Citation

Keywords

cervical neuroendocrine neoplasm; ovarian neuroendocrine neoplasm; carcinoid; management; small cell hypercalcemic ovarian tumor

About this article
Title

Contemporary principles of diagnostic and therapeutic management in cervical and ovarian neuroendocrine tumors

Journal

Ginekologia Polska

Issue

Vol 92, No 4 (2021)

Article type

Review paper

Pages

312-317

Published online

2021-03-12

DOI

10.5603/GP.a2020.0189

Pubmed

33751517

Bibliographic record

Ginekol Pol 2021;92(4):312-317.

Keywords

cervical neuroendocrine neoplasm
ovarian neuroendocrine neoplasm
carcinoid
management
small cell hypercalcemic ovarian tumor

Authors

Mariusz Bidzinski
Szymon Piatek
Jaroslaw Cwikla
Anna Nasierowska-Guttmejer
Anna Danska-Bidzinska

References (27)
  1. Chun YiK. Neuroendocrine Tumors of the Female Reproductive Tract: A Literature Review. J Pathol Transl Med. 2015 [Epub ahead of print].
  2. Atienza-Amores M, Guerini-Rocco E, Soslow RA, et al. Small cell carcinoma of the gynecologic tract: a multifaceted spectrum of lesions. Gynecol Oncol. 2014; 134(2): 410–418.
  3. Solcia E, Klöppel G, Sobin LH. Histological typing of endocrine tumours. Science & Business Media. 2012.
  4. Kurman RJ, Carcangiu ML, Herrington CS. WHO classification of tumours of the female reproductive organs. Lyon IARC Press 2014.
  5. Chiang YC, Chen YY, Hsieh SF, et al. Taiwan Cervical Cancer Prevention Surveillance Center. Screening frequency and histologic type influence the efficacy of cervical cancer screening: A nationwide cohort study. Taiwan J Obstet Gynecol. 2017; 56(4): 442–448.
  6. Li J, Ouyang Yi, Tao Y, et al. Small cell carcinoma of the cervix: analysis of clinical and pathological findings. Eur J Gynaecol Oncol. 1998; 19(2): 189–192.
  7. Zhou C, Hayes MM, Clement PB, et al. Small cell carcinoma of the uterine cervix: cytologic findings in 13 cases. Cancer. 1998; 84(5): 281–288.
  8. Park HJ, Choi YMi, Chung CK, et al. Pap smear screening for small cell carcinoma of the uterine cervix: a case series and review of the literature. J Gynecol Oncol. 2011; 22(1): 39–43.
  9. Kim MJ, Kim NaR, Cho HY, et al. Differential diagnostic features of small cell carcinoma in the uterine cervix. Diagn Cytopathol. 2008; 36(9): 618–623.
  10. Tempfer CB, Tischoff I, Dogan A, et al. Neuroendocrine carcinoma of the cervix: a systematic review of the literature. BMC Cancer. 2018; 18(1): 530.
  11. Kuji S, Watanabe R, Sato Y, et al. A new marker, insulinoma-associated protein 1 (INSM1), for high-grade neuroendocrine carcinoma of the uterine cervix: Analysis of 37 cases. Gynecol Oncol. 2017; 144(2): 384–390.
  12. McCluggage WG, Kennedy K, Busam KJ. An immunohistochemical study of cervical neuroendocrine carcinomas: Neoplasms that are commonly TTF1 positive and which may express CK20 and P63. Am J Surg Pathol. 2010; 34(4): 525–532.
  13. Castle PE, Pierz A, Stoler MH. A systematic review and meta-analysis on the attribution of human papillomavirus (HPV) in neuroendocrine cancers of the cervix. Gynecol Oncol. 2018; 148(2): 422–429.
  14. Fischerova D, Cibula D, Stenhova H, et al. Transrectal ultrasound and magnetic resonance imaging in staging of early cervical cancer. Int J Gynecol Cancer. 2008; 18(4): 766–772.
  15. Parikh JH, Barton DPJ, Ind TEJ, et al. MR imaging features of vaginal malignancies. Radiographics. 2008; 28(1): 49–63; quiz 322.
  16. Gardner GJ, Reidy-Lagunes D, Gehrig PA. Neuroendocrine tumors of the gynecologic tract: A Society of Gynecologic Oncology (SGO) clinical document. Gynecol Oncol. 2011; 122(1): 190–198.
  17. Lopes Dias J, Cunha TM, Gomes FV, et al. Neuroendocrine tumours of the female genital tract: a case-based imaging review with pathological correlation. Insights Imaging. 2015; 6(1): 43–52.
  18. Modlin IM, Shapiro MD, Kidd M. An analysis of rare carcinoid tumors: clarifying these clinical conundrums. World J Surg. 2005; 29(1): 92–101.
  19. Gadducci A, Carinelli S, Aletti G. Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists. Gynecol Oncol. 2017; 144(3): 637–646.
  20. Zivanovic O, Leitao MM, Park KJ, et al. Small cell neuroendocrine carcinoma of the cervix: Analysis of outcome, recurrence pattern and the impact of platinum-based combination chemotherapy. Gynecol Oncol. 2009; 112(3): 590–593.
  21. Gibbs J, Mei S, Economos K, et al. Clinicopathologic features, incidence, and survival trends of gynecologic neuroendocrine tumors: a SEER database analysis. AJOG. 2019; 221(1): 53.e1–53.e6.
  22. Chen J, Macdonald OK, Gaffney DK. Incidence, mortality, and prognostic factors of small cell carcinoma of the cervix. Obstet Gynecol. 2008; 111(6): 1394–1402.
  23. Embry JR, Kelly MG, Post MD, et al. Large cell neuroendocrine carcinoma of the cervix: prognostic factors and survival advantage with platinum chemotherapy. Gynecol Oncol. 2011; 120(3): 444–448.
  24. Salvo G, Gonzalez Martin A, Gonzales NR, et al. Updates and management algorithm for neuroendocrine tumors of the uterine cervix. Int J Gynecol Cancer. 2019; 29(6): 986–995.
  25. Sehouli J, Woopen H, Paaka M, et al. Neuroendocrine neoplasms of the ovary: a retrospective study of the North Eastern German Society of Gynecologic Oncology (NOGGO). Anticancer Res. 2016; 36: 1003–1010.
  26. Kupryjańczyk J, Dansonka-Mieszkowska A, Moes-Sosnowska J, et al. Ovarian small cell carcinoma of hypercalcemic type - evidence of germline origin and SMARCA4 gene inactivation. a pilot study. Pol J Pathol. 2013; 64(4): 238–246.
  27. Yang X, Chen J, Dong R. Pathological features, clinical presentations and prognostic factors of ovarian large cell neuroendocrine carcinoma: a case report and review of published literature. J Ovarian Res. 2019; 12(1): 69.

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