Vol 91, No 12 (2020)
Review paper
Published online: 2020-10-09
Biomarkers of angiogenesis in twin gestations and the risk of preeclampsia — review of the current literature
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Abstract
Twin pregnancy is one of the key risk factors for the development of preeclampsia.
Soluble fms-like tyrosine kinase-1, placental growth factor, and soluble endoglin are molecules involved in the process of
angiogenesis with a proven role in the pathogenesis of preeclampsia. The aim of the review was to summarize available
data on maternal serum levels of the biomarkers of angiogenesis and their usefulness in predicting preeclampsia in twin
pregnancies. Most of available data suggest biomarkers concentrations differ between singleton and twin gestation and
are related to chorionicity of twin pregnancy. Several algorithms including biomarkers of angiogenesis in prediction of
PE in twin pregnancy are available and seem promising, however more large prospective surveys are necessary to assess
their usefulness in general clinic use.
Keywords: placental growth factorserum soluble fms-like tyrosine kinase-1endoglinpreeclampsiatwin pregnancy
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