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Morphological estimation of incomplete uterine scar rupture (dehiscence) in post- cesarean deliveries. Immunohistochemical studies
, 2, 1
Affiliations- Department of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland
- Department of Human Nutrition and Metabolomics Pomeranian Medical University in Szczecin, Poland, Szczecin, Poland
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Abstract
Objectives: No studies were found that analysed the properties of the caesarean scar, therefore the new study analysed
the myometrial immunohistochemical expression of elastin, collagen type VI, alpha smooth muscle actin, smooth muscle
myosin heavy chain, and endothelial cell marker CD31.
The aim of the study was to determine the risk of uterine rupture in future pregnancies.
Material and methods: A total of 89 women of Caucasian ethnicity were eligible: 20 healthy pregnant women, who underwent
repeat caesarean section complicated by incomplete uterine scar rupture before labour, and 69 healthy pregnant
women, who underwent repeat caesarean section without subsequent uterine scar rupture as the control group. In all cases,
uterine tissue sample from the scarred region was collected during the caesarean section operation.
Results: The lack of observed significant changes of elastin, collagen type VI, alpha smooth muscle actin, smooth muscle
myosin heavy chain and endothelial cell marker CD31 concentrations in ruptured and unruptured uteri indicates that these
components cannot be found to be a marker of risk of uterine rupture in future pregnancies.
Conclusions: It could be suggested that the examined components do not contribute to the mechanism of maintaining
integrity and are not responsible for the biomechanical properties of the uterine scar.
Abstract
Objectives: No studies were found that analysed the properties of the caesarean scar, therefore the new study analysed
the myometrial immunohistochemical expression of elastin, collagen type VI, alpha smooth muscle actin, smooth muscle
myosin heavy chain, and endothelial cell marker CD31.
The aim of the study was to determine the risk of uterine rupture in future pregnancies.
Material and methods: A total of 89 women of Caucasian ethnicity were eligible: 20 healthy pregnant women, who underwent
repeat caesarean section complicated by incomplete uterine scar rupture before labour, and 69 healthy pregnant
women, who underwent repeat caesarean section without subsequent uterine scar rupture as the control group. In all cases,
uterine tissue sample from the scarred region was collected during the caesarean section operation.
Results: The lack of observed significant changes of elastin, collagen type VI, alpha smooth muscle actin, smooth muscle
myosin heavy chain and endothelial cell marker CD31 concentrations in ruptured and unruptured uteri indicates that these
components cannot be found to be a marker of risk of uterine rupture in future pregnancies.
Conclusions: It could be suggested that the examined components do not contribute to the mechanism of maintaining
integrity and are not responsible for the biomechanical properties of the uterine scar.
Keywords
uterine scar; elastin; collagen; actin; myosin; endothelial cell marker CD3
About this articleTitle
Morphological estimation of incomplete uterine scar rupture (dehiscence) in post- cesarean deliveries. Immunohistochemical studies
Journal
Issue
Article type
Research paper
Pages
685-692
Published online
2020-11-30
Page views
783
Article views/downloads
1185
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(11):685-692.
Keywords
uterine scar
elastin
collagen
actin
myosin
endothelial cell marker CD3
Authors
Maciej Zietek
Małgorzata Szczuko
Zbigniew Celewicz
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