open access

Vol 91, No 11 (2020)
Research paper
Published online: 2020-11-30
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Morphological estimation of incomplete uterine scar rupture (dehiscence) in post- cesarean deliveries. Immunohistochemical studies

Maciej Zietek1, Małgorzata Szczuko2, Zbigniew Celewicz1
DOI: 10.5603/GP.2020.0115
·
Pubmed: 33301163
·
Ginekol Pol 2020;91(11):685-692.
Affiliations
  1. Department of Perinatology, Obstetrics and Gynecology, Pomeranian Medical University, Szczecin, Poland
  2. Department of Human Nutrition and Metabolomics Pomeranian Medical University in Szczecin, Poland, Szczecin, Poland

open access

Vol 91, No 11 (2020)
ORIGINAL PAPERS Obstetrics
Published online: 2020-11-30

Abstract

Objectives: No studies were found that analysed the properties of the caesarean scar, therefore the new study analysed
the myometrial immunohistochemical expression of elastin, collagen type VI, alpha smooth muscle actin, smooth muscle
myosin heavy chain, and endothelial cell marker CD31.
The aim of the study was to determine the risk of uterine rupture in future pregnancies.
Material and methods: A total of 89 women of Caucasian ethnicity were eligible: 20 healthy pregnant women, who underwent
repeat caesarean section complicated by incomplete uterine scar rupture before labour, and 69 healthy pregnant
women, who underwent repeat caesarean section without subsequent uterine scar rupture as the control group. In all cases,
uterine tissue sample from the scarred region was collected during the caesarean section operation.
Results: The lack of observed significant changes of elastin, collagen type VI, alpha smooth muscle actin, smooth muscle
myosin heavy chain and endothelial cell marker CD31 concentrations in ruptured and unruptured uteri indicates that these
components cannot be found to be a marker of risk of uterine rupture in future pregnancies.
Conclusions: It could be suggested that the examined components do not contribute to the mechanism of maintaining
integrity and are not responsible for the biomechanical properties of the uterine scar.

Abstract

Objectives: No studies were found that analysed the properties of the caesarean scar, therefore the new study analysed
the myometrial immunohistochemical expression of elastin, collagen type VI, alpha smooth muscle actin, smooth muscle
myosin heavy chain, and endothelial cell marker CD31.
The aim of the study was to determine the risk of uterine rupture in future pregnancies.
Material and methods: A total of 89 women of Caucasian ethnicity were eligible: 20 healthy pregnant women, who underwent
repeat caesarean section complicated by incomplete uterine scar rupture before labour, and 69 healthy pregnant
women, who underwent repeat caesarean section without subsequent uterine scar rupture as the control group. In all cases,
uterine tissue sample from the scarred region was collected during the caesarean section operation.
Results: The lack of observed significant changes of elastin, collagen type VI, alpha smooth muscle actin, smooth muscle
myosin heavy chain and endothelial cell marker CD31 concentrations in ruptured and unruptured uteri indicates that these
components cannot be found to be a marker of risk of uterine rupture in future pregnancies.
Conclusions: It could be suggested that the examined components do not contribute to the mechanism of maintaining
integrity and are not responsible for the biomechanical properties of the uterine scar.

Get Citation

Keywords

uterine scar; elastin; collagen; actin; myosin; endothelial cell marker CD3

About this article
Title

Morphological estimation of incomplete uterine scar rupture (dehiscence) in post- cesarean deliveries. Immunohistochemical studies

Journal

Ginekologia Polska

Issue

Vol 91, No 11 (2020)

Article type

Research paper

Pages

685-692

Published online

2020-11-30

DOI

10.5603/GP.2020.0115

Pubmed

33301163

Bibliographic record

Ginekol Pol 2020;91(11):685-692.

Keywords

uterine scar
elastin
collagen
actin
myosin
endothelial cell marker CD3

Authors

Maciej Zietek
Małgorzata Szczuko
Zbigniew Celewicz

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