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The role of biological markers in predicting infertility associated with non-obstructive endometriosis
Affiliations- “Carol Davila” University of Medicine and Pharmacy, Department of Obstetrics and Gynecology, Bucharest, Romania
- Gynaecology Department - Filantropia Clinical Hospital, Bucharest, Romania
open access
Abstract
Objectives: Our study evaluates if the use of biological markers can predict the infertility in women with non-obstructive
endometriosis.
Material and methods: Two prospective, non-randomised studies were conducted to identify if CA-125, IL-6 and IL-8 can be
used as predictive markers for infertility in women with non-obstructive endometriosis. Peripheral levels of CA-125, IL-6 and
IL-8 were measured before laparoscopy in all patients.
Results: We found a total number of 152 patients with non-obstructive endometriosis, we divided them in two groups: fertile
and infertile women. There was a statistically significant difference of the mean of CA-125 values between the two groups
(p = 0.00). The patients with infertility had a significantly higher IL-6 serum values than the fertile patients (p = 0.00). Regarding
the IL-8 serum values, there was no statistically significant difference between the two groups fertile vs infertile, (p = 0.06).
Conclusions: The elevated serum levels of CA-125 and IL-6 was associated with an increased probability of being diagnosed
with infertility. The IL-8 had no value in predicting infertility associated with non-obstructive endometriosis.
Abstract
Objectives: Our study evaluates if the use of biological markers can predict the infertility in women with non-obstructive
endometriosis.
Material and methods: Two prospective, non-randomised studies were conducted to identify if CA-125, IL-6 and IL-8 can be
used as predictive markers for infertility in women with non-obstructive endometriosis. Peripheral levels of CA-125, IL-6 and
IL-8 were measured before laparoscopy in all patients.
Results: We found a total number of 152 patients with non-obstructive endometriosis, we divided them in two groups: fertile
and infertile women. There was a statistically significant difference of the mean of CA-125 values between the two groups
(p = 0.00). The patients with infertility had a significantly higher IL-6 serum values than the fertile patients (p = 0.00). Regarding
the IL-8 serum values, there was no statistically significant difference between the two groups fertile vs infertile, (p = 0.06).
Conclusions: The elevated serum levels of CA-125 and IL-6 was associated with an increased probability of being diagnosed
with infertility. The IL-8 had no value in predicting infertility associated with non-obstructive endometriosis.
Keywords
CA-125; IL-6; IL-8; biological marker; non-obstructive endometriosis; prediction of infertility
About this articleTitle
The role of biological markers in predicting infertility associated with non-obstructive endometriosis
Journal
Issue
Article type
Research paper
Pages
189-192
Published online
2020-04-29
Page views
1526
Article views/downloads
1172
DOI
Pubmed
Bibliographic record
Ginekol Pol 2020;91(4):189-192.
Keywords
CA-125
IL-6
IL-8
biological marker
non-obstructive endometriosis
prediction of infertility
Authors
Nicolae Gica
Anca Maria Panaitescu
George Iancu
Radu Botezatu
Gheorghe Peltecu
Corina Gica
References (14)- Giudice L, Kao L. Endometriosis. The Lancet. 2004; 364(9447): 1789–1799.
- Fassbender A. Biomarkers of endometriosis. Fertility and Sterility. 2013; 99: 1135–1144.
- Eskenazi B, Warner M. Epidemiology of endometriosis. Obstetrics and Gynecology Clinics of North America. 1997; 24(2): 235–258.
- Fassbender A, Burney RO, O DF, et al. Update on Biomarkers for the Detection of Endometriosis. Biomed Res Int. 2015; 2015: 130854.
- Counseller V. Endometriosis. American Journal of Obstetrics and Gynecology. 1938; 36(5): 877–888.
- de Ziegler D, Pirtea P, Carbonnel M, et al. Implantation markers and endometriosis. Reprod Biomed Online. 2005; 11(4): 464–468.
- Carmona F, Chapron C, Martínez-Zamora MÁ, et al. Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6. J Reprod Immunol. 2012; 95(1-2): 80–95.
- Carp HJA, Selmi C, Shoenfeld Y. The autoimmune bases of infertility and pregnancy loss. J Autoimmun. 2012; 38(2-3): 266–274.
- May KE, Conduit-Hulbert SA, Villar J, et al. Peripheral biomarkers of endometriosis: a systematic review. Hum Reprod Update. 2010; 16(6): 1–24.
- Gupta S, Agarwal A, Sekhon L, et al. Serum and peritoneal abnormalities in endometriosis: potential use as diagnostic markers. Minerva Ginecol. 2006; 58(6): 527–551.
- Othman EED, Hornung D, Salem HT, et al. Serum cytokines as biomarkers for nonsurgical prediction of endometriosis. Eur J Obstet Gynecol Reprod Biol. 2008; 137(2): 240–246.
- Bedaiwy MA, Falcone T, Sharma RK, et al. Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial. Hum Reprod. 2002; 17(2): 426–431.
- Ohata Y, Harada T, Miyakoda H, et al. Serum interleukin-8 levels are elevated in patients with ovarian endometrioma. Fertil Steril. 2008; 90(4): 994–999.
- Salmeri FM, Laganà AS, Sofo V, et al. Behaviour of cytokine levels in serum and peritoneal fluid of women with endometriosis. Gynecol Obstet Invest. 2002; 54(2): 82–87.
