Clinicopathological factors of pelvic lymph nodes involvement in advanced serous ovarian cancer
Abstract
Objectives: Retroperitoneal lymph nodes metastases occur frequently in patients with ovarian cancer. Lymphadenectomy
increases risk of perioperative complications. In clinical practice to reduce rate of complications aortocaval lymphadenectomy
is omitted and solely resection of pelvic lymph nodes is performed. To establish factors affecting metastases to pelvic
lymph nodes in advanced ovarian cancer.
Material and methods: A retrospective study among patients with serous advanced ovarian cancer (FIGO IIIB–IVB) was
conducted at the 1st Department of Obstetrics and Gynecology, Medical University of Warsaw and Department of Gynecologic
Oncology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw. All patients underwent
surgical treatment including pelvic lymphadenectomy between 2014 and 2017. Data including age, body mass index
(BMI), pretreatment CA125 serum level, tumor volume, grading, one-/both-sided tumor, menopausal status, ascites were
analysed as possible factors influencing the pelvic lymph nodes involvement. The statistical analysis was performed with
Python software.
Results: 87 consecutive patients were eligible for the study. Metastases to pelvic lymph nodes were found in 29 (33.33%)
patients. Pretreatment serum CA-125 concentration (652 U/mL vs 360.9 U/mL, p < 0.05) and high grade histology corresponded
with pelvic nodal involvement.
Conclusions: The knowledge of factors influencing metastases to pelvic lymph nodes may help clinicians in proper counselling
and tailoring of therapy.
Keywords: ovarian cancermetastasis to pelvic lymph nodeclinicopathological factors
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