Vol 91, No 3 (2020)
Research paper
Published online: 2020-03-31

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Application of prenatal ultrasonography and magnetic resonance imaging on fetal agenesis of corpus callosum

Ai-Ping Min1, Li-Hua Zou2
Pubmed: 32266953
Ginekol Pol 2020;91(3):132-136.

Abstract

Objectives: To evaluate the diagnostic value and clinical application of prenatal ultrasonography (US) and Magnetic Resonance Imaging (MRI) for different types of fetal Agenesis of the Corpus Callosum (ACC). Material and methods: There were 42 cases of fetal ACC discovered by routine US, including complete ACC 18 cases and partial ACC 24 cases, checked by MRI within 1 week. The results were confirmed by head ultrasound after birth or brain biopsy after labor induction. Results: From prenatal ultrasonic diagnosis, 18 cases were complete ACC and 24 cases were partial ACC. MRI was able to find complete ACC in 11 cases, partial ACC in 16 cases, and non-ACC in 15 cases. Labor induction or birth confirmed that, 11 cases were complete ACC, 14 cases were partial ACC, and 17 cases were non-ACC.The results of different types of ACC were detected by ultrasound and MRI were statistically significant (p < 0.05).MRI examination was superior to ultrasound in specificity, positive predictive value, negative predictive value, Youden index, and diagnostic index. Conclusions: MRI is high specific degrees, diagnostic performance is satisfactory, should be use as a necessary method for prenatal definitive diagnosis of ACC. However, prenatal ultrasound can be tested repeatedly and can be combined with blood flow imaging detection in real time, and it is still the preferred method for screening fetal structural malformation in a comprehensive way, which is suitable for general screening of ACC.

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References

  1. Santo S, D'Antonio F, Homfray T, et al. Counseling in fetal medicine: agenesis of the corpus callosum. Ultrasound Obstet Gynecol. 2012; 40(5): 513–521.
  2. Manevich-Mazor M, Weissmann-Brenner A, Bar Yosef O, et al. Added Value of Fetal MRI in the Evaluation of Fetal Anomalies of the Corpus Callosum: A Retrospective Analysis of 78 Cases. Ultraschall Med. 2018; 39(5): 513–525.
  3. Santirocco M, Rodó C, Illescas T, et al. Accuracy of prenatal ultrasound in the diagnosis of corpus callosum anomalies. J Matern Fetal Neonatal Med. 2019 [Epub ahead of print]: 1–6.
  4. D'Antonio F, Pagani G, Familiari A, et al. Outcomes Associated With Isolated Agenesis of the Corpus Callosum: A Meta-analysis. Pediatrics. 2016; 138(3).
  5. Achiron R, Achiron A. Development of the human fetal corpus callosum: a high-resolution, cross-sectional sonographic study. Ultrasound Obstet Gynecol. 2001; 18(4): 343–347.
  6. Rathee S, Joshi P, Kelkar A, et al. Fetal MRI: A pictorial essay. Indian J Radiol Imaging. 2016; 26(1): 52–62.
  7. Duczkowska A, Olwert A, Duczkowski M, et al. Postnatal verification of prenatal diagnoses established on foetal magnetic resonance imaging. Ginekol Pol. 2018; 89(5): 262–270.
  8. Sotiriadis A, Makrydimas G. Neurodevelopment after prenatal diagnosis of isolated agenesis of the corpus callosum: an integrative review. Am J Obstet Gynecol. 2012; 206(4): 337.e1–337.e5.
  9. Peker N, Turan V, Ergenoglu M, et al. Assessment of total placenta previa by magnetic resonance imaging and ultrasonography to detect placenta accreta and its variants. Ginekol Pol. 2013; 84(3): 186–192.