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Influence of MiRNAs in gestational diabetes mellitus development
, 1
Affiliations- Department of Gynecology and Gynecological Oncology, Medical University of Bialystok, Poland
open access
Abstract
Gestational Diabetes Mellitus (GDM) is a metabolic disorder that is considered a prediabetes state. According to the International Diabetes Federation every year an increase in the number of women diagnosed with gestational diabetes is being noticed. It is known that GDM can cause many complications during pregnancy and labor. What is more, women with GDM history and their offspring are at risk of developing diabetes in the future. A new factor in the pathogenesis of GDM is epigenetics, which is described as changes in gene expression without directly modifying the DNA sequence. One of its regulating mechanisms is based on microRNA (miRNA). A small non-coding RNA sequence that has an influence on protein formation by suppressing gene expression. A better understanding of the miRNA’s function could potentially lead to their usage as potential new biomarkers or treatment targets. In this article we review the most significant miRNA molecules in gestational diabetes.
Abstract
Gestational Diabetes Mellitus (GDM) is a metabolic disorder that is considered a prediabetes state. According to the International Diabetes Federation every year an increase in the number of women diagnosed with gestational diabetes is being noticed. It is known that GDM can cause many complications during pregnancy and labor. What is more, women with GDM history and their offspring are at risk of developing diabetes in the future. A new factor in the pathogenesis of GDM is epigenetics, which is described as changes in gene expression without directly modifying the DNA sequence. One of its regulating mechanisms is based on microRNA (miRNA). A small non-coding RNA sequence that has an influence on protein formation by suppressing gene expression. A better understanding of the miRNA’s function could potentially lead to their usage as potential new biomarkers or treatment targets. In this article we review the most significant miRNA molecules in gestational diabetes.
Keywords
gestational diabetes mellitus; GDM; miRNA; epigenetics
About this articleTitle
Influence of MiRNAs in gestational diabetes mellitus development
Journal
Issue
Article type
Review paper
Pages
579-582
Published online
2021-05-20
Page views
1809
Article views/downloads
1417
DOI
Pubmed
Bibliographic record
Ginekol Pol 2021;92(8):579-582.
Keywords
gestational diabetes mellitus
GDM
miRNA
epigenetics
Authors
Ilona Juchnicka
Mariusz Kuzmicki
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