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The assessment of spectral Doppler parameters in uterine arteries of patients with locally advanced squamous cell cervical cancer
, 2, 3, 34, 4, 34
Affiliations- Department of Radiology — Copernicus Memorial Hospital, Lodz, Poland
- Department of Biostatistics and Translational Medicine, Medical University of Lodz, Poland
- Department of Teleradiotherapy, Regional Cancer Centre, Copernicus Memorial Hospital of Lodz, Poland
- Department of Radiotherapy, Chair of Oncology, Medical University of Lodz, Poland
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Abstract
Objectives: Evaluate spectral Doppler parameters peak systolic velocity (PSV), end diastolic velocity (EDV), resistance index (RI) and pulsatility index (PI) in infiltrated and non-infiltrated uterine arteries of patients with locally advanced (stages II B, III B) squamous cell cervical cancer and their changes during treatment.
Material and methods: the study group included 36 patients aged 35–78 years old. At diagnosis, PSV, EDV, RI and PI in uterine arteries were examined and compared with MRI findings. All patients underwent transvaginal doppler ultrasonography prior to the treatment, after external beam radiation therapy and six weeks after the last application of brachytherapy.
Results: The median PSV value in the first examination was higher in infiltrated uterine arteries than compared to non-infiltrated ones (p = 0.001). The PSV values for all vessels decreased between the first and the third observation (p < 0.001). There was a significant difference in PI values between infiltrated and non-infiltrated uterine arteries between the first and the third examination (p = 0.027).
Conclusions: In patients with locally advanced cervical cancer of uterine arteries, assessment of PSV but not EDV, RI or PI can be helpful in differentiating infiltrated from non-infiltrated vessels. In this group of patients, radiotherapy decreases PSV, but not EDV, RI or PI values in uterine arteries. An observation conducted from the onset of radiotherapy to end of the follow-up in uterine arteries reveals that PI, but not RI, PSV or EDV, is different in infiltrated and non-infiltrated vessels.
Abstract
Objectives: Evaluate spectral Doppler parameters peak systolic velocity (PSV), end diastolic velocity (EDV), resistance index (RI) and pulsatility index (PI) in infiltrated and non-infiltrated uterine arteries of patients with locally advanced (stages II B, III B) squamous cell cervical cancer and their changes during treatment.
Material and methods: the study group included 36 patients aged 35–78 years old. At diagnosis, PSV, EDV, RI and PI in uterine arteries were examined and compared with MRI findings. All patients underwent transvaginal doppler ultrasonography prior to the treatment, after external beam radiation therapy and six weeks after the last application of brachytherapy.
Results: The median PSV value in the first examination was higher in infiltrated uterine arteries than compared to non-infiltrated ones (p = 0.001). The PSV values for all vessels decreased between the first and the third observation (p < 0.001). There was a significant difference in PI values between infiltrated and non-infiltrated uterine arteries between the first and the third examination (p = 0.027).
Conclusions: In patients with locally advanced cervical cancer of uterine arteries, assessment of PSV but not EDV, RI or PI can be helpful in differentiating infiltrated from non-infiltrated vessels. In this group of patients, radiotherapy decreases PSV, but not EDV, RI or PI values in uterine arteries. An observation conducted from the onset of radiotherapy to end of the follow-up in uterine arteries reveals that PI, but not RI, PSV or EDV, is different in infiltrated and non-infiltrated vessels.
Keywords
cervical cancer; locally advanced; spectral Doppler; uterine artery; infiltration
About this articleTitle
The assessment of spectral Doppler parameters in uterine arteries of patients with locally advanced squamous cell cervical cancer
Journal
Issue
Article type
Research paper
Pages
622-627
Published online
2019-11-28
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950
Article views/downloads
1054
DOI
Pubmed
Bibliographic record
Ginekol Pol 2019;90(11):622-627.
Keywords
cervical cancer
locally advanced
spectral Doppler
uterine artery
infiltration
Authors
Adam Tomalczyk
Bartlomiej Tomasik
Malgorzata Moszynska-Zielinska
Jacek Fijuth
Michal Spych
Leszek Gottwald
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