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A comparison in an experimental rat model of the effects on adhesion formation of different hemostatic methods used in abdominopelvic surgery
, 2, 3, 4, 5, 6, 7
Affiliations- Department of Obstetrics and Gynecology, Birecik State Hospital, Şanlıurfa, Turkey
- Department of Obstetrics and Gynecology, Kahramanmaraş Sütçü İmam University, School of Medicine, Turkey
- Department of General Surgery, Kahramanmaraş Sütçü İmam University, School of Medicine, Turkey
- Private Clinic, Kahramanmaraş, Turkey
- Department of Histology and Embriyology, Kahramanmaraş Sütçü İmam University, School of Medicine, Turkey
- Department of Anesthesiology and Reanimation, Kahramanmaraş Sütçü İmam University, School of Medicine, Turkey
- Department of Pathology, Kahramanmaraş Sütçü İmam University, School of Medicine, Turkey
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Abstract
Objectives: To evaluate the effects of different hemostasis methods used in abdominal surgery on the development of abdominal adhesion.
Material and methods: A total of 48 Wistar albino female rats were separated into six groups; Group 1 — Control group, Group 2 — Hemorrhage group, Group 3 — Electrocoautery group, Group 4 — Gel Spon-P®, Group 5 — PAHACEL®, and Group 6 — Ankaferd-Blood Stopper®. Adhesions that developed were scored according to the Knightly classification and the prevalence of adhesions according to the Linsky classification. The total adhesion score was calculated as the total of the severity and prevalence scores.
Results: The lowest total adhesion values were determined in Group 1 (control) and the highest adhesion values were in Group 2 (hemorrhage) group in terms of all parameters. The adhesion values in Group 3, where the rats were administered hemostasis with electrocautery were similar to those of Group 2 (hemorrhage). When the alternative methods were evaluated, the lowest adhesion scores were in Group 6 (Ankaferd-Blood Stopper®).
Conclusions: In cases of minor pelvic or abdominal bleeding, not providing hemostasis or applying hemostasis with electrocautery can increase the development of intra-abdominal adhesions. The use of alternative hemostatic materials instead of electrocautery for hemostasis may reduce the formation of adhesions.
Abstract
Objectives: To evaluate the effects of different hemostasis methods used in abdominal surgery on the development of abdominal adhesion.
Material and methods: A total of 48 Wistar albino female rats were separated into six groups; Group 1 — Control group, Group 2 — Hemorrhage group, Group 3 — Electrocoautery group, Group 4 — Gel Spon-P®, Group 5 — PAHACEL®, and Group 6 — Ankaferd-Blood Stopper®. Adhesions that developed were scored according to the Knightly classification and the prevalence of adhesions according to the Linsky classification. The total adhesion score was calculated as the total of the severity and prevalence scores.
Results: The lowest total adhesion values were determined in Group 1 (control) and the highest adhesion values were in Group 2 (hemorrhage) group in terms of all parameters. The adhesion values in Group 3, where the rats were administered hemostasis with electrocautery were similar to those of Group 2 (hemorrhage). When the alternative methods were evaluated, the lowest adhesion scores were in Group 6 (Ankaferd-Blood Stopper®).
Conclusions: In cases of minor pelvic or abdominal bleeding, not providing hemostasis or applying hemostasis with electrocautery can increase the development of intra-abdominal adhesions. The use of alternative hemostatic materials instead of electrocautery for hemostasis may reduce the formation of adhesions.
Keywords
intra-abdominal hemorrhage; abdominal adhesion; hemostatic agents; pelvic surgery; hemostasis
About this articleTitle
A comparison in an experimental rat model of the effects on adhesion formation of different hemostatic methods used in abdominopelvic surgery
Journal
Issue
Article type
Research paper
Pages
507-512
Published online
2019-09-30
Page views
2192
Article views/downloads
1146
DOI
Pubmed
Bibliographic record
Ginekol Pol 2019;90(9):507-512.
Keywords
intra-abdominal hemorrhage
abdominal adhesion
hemostatic agents
pelvic surgery
hemostasis
Authors
Erkan Mavigök
Murat Bakacak
Fatih Mehmet Yazar
Zeyneb Bakacak
Aslı Yaylalı
Ömer Faruk Boran
Abdulkadir Yasir Bahar
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