A comparison in an experimental rat model of the effects on adhesion formation of different hemostatic methods used in abdominopelvic surgery
, 2, 3, 4, 5, 6, 7
Abstract
Objectives: To evaluate the effects of different hemostasis methods used in abdominal surgery on the development of abdominal adhesion.
Material and methods: A total of 48 Wistar albino female rats were separated into six groups; Group 1 — Control group, Group 2 — Hemorrhage group, Group 3 — Electrocoautery group, Group 4 — Gel Spon-P®, Group 5 — PAHACEL®, and Group 6 — Ankaferd-Blood Stopper®. Adhesions that developed were scored according to the Knightly classification and the prevalence of adhesions according to the Linsky classification. The total adhesion score was calculated as the total of the severity and prevalence scores.
Results: The lowest total adhesion values were determined in Group 1 (control) and the highest adhesion values were in Group 2 (hemorrhage) group in terms of all parameters. The adhesion values in Group 3, where the rats were administered hemostasis with electrocautery were similar to those of Group 2 (hemorrhage). When the alternative methods were evaluated, the lowest adhesion scores were in Group 6 (Ankaferd-Blood Stopper®).
Conclusions: In cases of minor pelvic or abdominal bleeding, not providing hemostasis or applying hemostasis with electrocautery can increase the development of intra-abdominal adhesions. The use of alternative hemostatic materials instead of electrocautery for hemostasis may reduce the formation of adhesions.
Keywords: intra-abdominal hemorrhageabdominal adhesionhemostatic agentspelvic surgeryhemostasis
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