open access

Vol 90, No 12 (2019)
Research paper
Published online: 2019-12-31
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Ghrelin does not change in hyperemesis gravidarum

Serhat Ege1, Ali Kolusarı2, Güler Buğdaycı3, Numan Çim4, Muhammet Hanifi Bademkıran1, Nurullah Peker5, Selami Erdem1, Çağdaş Özgökçe6, Recep Yıldızhan4
·
Pubmed: 31909462
·
Ginekol Pol 2019;90(12):699-701.
Affiliations
  1. Department of Gynecology and Obstetrics, Health Sciences University, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey
  2. YuzuncuDepartment of Gynecology and Obstetrics, Yüzüncüyıl University, VAN, Turkey
  3. Department of Biochemistry, İzzet Baysal University, Bolu, Turkey
  4. Department of Gynecology and Obstetrics, İstanbul Science University, Florance Nightingale Hospital, İstanbul, Turkey
  5. Department of Gynecology and Obstetrics, Dicle University, Diyarbakır, Turkey
  6. Department of Gynecology and Obstetrics, Akdamar Hospital, VAN, Turkey

open access

Vol 90, No 12 (2019)
ORIGINAL PAPERS Obstetrics
Published online: 2019-12-31

Abstract

Objectives: Ghrelin levels can play an important role in maintaining the energy balance of pregnant women. Therefore,
we investigated the relationship between HG and Ghrelin.
Material and methods: 50 female patients admitted to the VAN Yüzüncü Yıl University, Gynecology and Obstetrics Department
were evaluated. The patients were divided into two groups: Group 1 included 25 pregnant women with HG, Group 2
included 25 healthy pregnant women.
Results: The two groups showed similarities in terms of age, gravidity, B-HCG and gestational age. There was no statistically
significant difference between the two groups in terms of the Ghrelin levels (p = 0.867).
Conclusions: This study shows that there is no difference between Ghrelin levels and HG during pregnancy. Increased
Ghrelin in previous studies was attributed to low oral intake. Another study reported lower Ghrelin levels are not the result
of, but are rather the cause of, reduced oral intake during. The balancing of these two conditions does not lead to a change
in the level of Ghrelin.

Abstract

Objectives: Ghrelin levels can play an important role in maintaining the energy balance of pregnant women. Therefore,
we investigated the relationship between HG and Ghrelin.
Material and methods: 50 female patients admitted to the VAN Yüzüncü Yıl University, Gynecology and Obstetrics Department
were evaluated. The patients were divided into two groups: Group 1 included 25 pregnant women with HG, Group 2
included 25 healthy pregnant women.
Results: The two groups showed similarities in terms of age, gravidity, B-HCG and gestational age. There was no statistically
significant difference between the two groups in terms of the Ghrelin levels (p = 0.867).
Conclusions: This study shows that there is no difference between Ghrelin levels and HG during pregnancy. Increased
Ghrelin in previous studies was attributed to low oral intake. Another study reported lower Ghrelin levels are not the result
of, but are rather the cause of, reduced oral intake during. The balancing of these two conditions does not lead to a change
in the level of Ghrelin.

Get Citation

Keywords

Ghrelin; Hyperemesis Gravidarum; Etiopathogenesis

About this article
Title

Ghrelin does not change in hyperemesis gravidarum

Journal

Ginekologia Polska

Issue

Vol 90, No 12 (2019)

Article type

Research paper

Pages

699-701

Published online

2019-12-31

Page views

1332

Article views/downloads

918

DOI

10.5603/GP.2019.0119

Pubmed

31909462

Bibliographic record

Ginekol Pol 2019;90(12):699-701.

Keywords

Ghrelin
Hyperemesis Gravidarum
Etiopathogenesis

Authors

Serhat Ege
Ali Kolusarı
Güler Buğdaycı
Numan Çim
Muhammet Hanifi Bademkıran
Nurullah Peker
Selami Erdem
Çağdaş Özgökçe
Recep Yıldızhan

References (12)
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  3. Rashid M, Rashid MH, Malik F, et al. Hyperemesis gravidarum and fetal gender: a retrospective study. J Obstet Gynaecol. 2012; 32(5): 475–478.
  4. Shintani M, Ogawa Y, Ebihara K, et al. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes. 2001; 50(2): 227–232.
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  6. Aka N, Atalay S, Sayharman S, et al. Leptin and leptin receptor levels in pregnant women with hyperemesis gravidarum. Aust N Z J Obstet Gynaecol. 2006; 46(4): 274–277.
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  8. Oruç AS, Mert I, Akturk M, et al. Ghrelin and motilin levels in hyperemesis gravidarum. Arch Gynecol Obstet. 2013; 287(6): 1087–1092.
  9. Tschöp M, Wawarta R, Riepl RL, et al. Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest. 2001; 24(6): RC19–RC21.
  10. KAYGUSUZ İ, GÜMÜŞ İİ, YILDIRIM M, et al. Association between maternal ghrelin levels and hyperemesis gravidarum. TURKISH JOURNAL OF MEDICAL SCIENCES. 2013; 43: 790–794.
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  12. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai. 2007; 90(1): 15–20.

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