open access

Vol 90, No 7 (2019)
Research paper
Published online: 2019-07-26
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Exposure to dolutegravir in pregnant women living with HIV in Central and Eastern Europe and neighboring countries — data from the ECEE Network Group

Deniz Gokengin1, Inka Aho2, Figen Sarıgül Yıldırım3, Pavla Bukovinova4, Ewa Siwak5, Antonios Papadopoulos6, Dalibor Sedlacek7, Justyna Kowalska58
·
Pubmed: 31392711
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Ginekol Pol 2019;90(7):411-415.
Affiliations
  1. Ege University Faculty of Medicine Department of Infectious Diseases, Izmir, Turkey
  2. Helsinki University Hospital, Helsinki, Finland
  3. Health Science University Antalya Education and Training Hospital, Antalya, Turkey
  4. Department of Infectious Diseases and Geographical Medicine UH, Bratislava, Slovakia
  5. Hospital for Infectious Diseases, HIV Out-Patient Clinic, Warsaw, Poland
  6. University Hospital, Athens, Greece
  7. HIV Centre, Department of Infectious Diseases, University Hospital, Plzen, Czech Republic
  8. Medical University of Warsaw, Department of Adult’s Infectious Diseases, Warsaw, Poland

open access

Vol 90, No 7 (2019)
ORIGINAL PAPERS Obstetrics
Published online: 2019-07-26

Abstract

Objectives: The purpose of this study was to investigate dolutegravir (DTG) use among women and exposure to DTG during pregnancy in real world in Central and Eastern Europe and neighboring countries.

Material and methods: Centres from 20 countries included in the Euroguidelines in Central and Eastern Europe (ECEE) Network and Finland were asked to complete an on-line questionnaire.

Results: Seven centres from Czech Republic, Finland, Greece, Poland, Slovakia, and Turkey provided detailed information. DTG exposure was reported in 415 women, of which 26 were during pregnancy. Of those, 22 were on DTG at the time of conception and 4 had started DTG during pregnancy. Few women had conventional risk factors. The data on folic acid usage was unknown for eight women; 14 were using and four were not using folic acid. Four pregnancies were ongoing at the time of the study and of those with an outcome, 77.3% resulted with term, 13.6% preterm delivery, 4.5% spontaneous and 4.5% medical abortion.

Conclusions: The DTG signal report indicates the importance of safety research for drug use in pregnancy and highlights the urgent need for systematic surveillance of pregnancy outcomes and neonatal surveillance. Countries with low- or moderate HIV prevalence should be included in studies reviewing pregnancy outcomes and in any surveillance system to ensure the accuracy of drug safety revision.

Abstract

Objectives: The purpose of this study was to investigate dolutegravir (DTG) use among women and exposure to DTG during pregnancy in real world in Central and Eastern Europe and neighboring countries.

Material and methods: Centres from 20 countries included in the Euroguidelines in Central and Eastern Europe (ECEE) Network and Finland were asked to complete an on-line questionnaire.

Results: Seven centres from Czech Republic, Finland, Greece, Poland, Slovakia, and Turkey provided detailed information. DTG exposure was reported in 415 women, of which 26 were during pregnancy. Of those, 22 were on DTG at the time of conception and 4 had started DTG during pregnancy. Few women had conventional risk factors. The data on folic acid usage was unknown for eight women; 14 were using and four were not using folic acid. Four pregnancies were ongoing at the time of the study and of those with an outcome, 77.3% resulted with term, 13.6% preterm delivery, 4.5% spontaneous and 4.5% medical abortion.

Conclusions: The DTG signal report indicates the importance of safety research for drug use in pregnancy and highlights the urgent need for systematic surveillance of pregnancy outcomes and neonatal surveillance. Countries with low- or moderate HIV prevalence should be included in studies reviewing pregnancy outcomes and in any surveillance system to ensure the accuracy of drug safety revision.

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Keywords

HIV infection; dolutegravir; pregnancy; Central and Eastern Europe

About this article
Title

Exposure to dolutegravir in pregnant women living with HIV in Central and Eastern Europe and neighboring countries — data from the ECEE Network Group

Journal

Ginekologia Polska

Issue

Vol 90, No 7 (2019)

Article type

Research paper

Pages

411-415

Published online

2019-07-26

Page views

1433

Article views/downloads

1031

DOI

10.5603/GP.2019.0070

Pubmed

31392711

Bibliographic record

Ginekol Pol 2019;90(7):411-415.

Keywords

HIV infection
dolutegravir
pregnancy
Central and Eastern Europe

Authors

Deniz Gokengin
Inka Aho
Figen Sarıgül Yıldırım
Pavla Bukovinova
Ewa Siwak
Antonios Papadopoulos
Dalibor Sedlacek
Justyna Kowalska

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