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Vol 90, No 1 (2019)
Research paper
Published online: 2019-01-31
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Metabolic and hormonal effects of a combined Myo-inositol and d-chiro-inositol therapy on patients with polycystic ovary syndrome (PCOS)

Marcin Januszewski1, Tadeusz Issat12, Alicja A Jakimiuk3, Malgorzata Santor-Zaczynska1, Artur J Jakimiuk12
DOI: 10.5603/GP.2019.0002
·
Pubmed: 30756365
·
Ginekol Pol 2019;90(1):7-10.
Affiliations
  1. Department of Obstetrics and Gynecology, Central Clinical Hospital of Interior, Warsaw, Poland
  2. Center of Reproductive Health, Institute of Mother and Child, Warsaw, Poland
  3. First Faculty of Medicine, Medical University of Warsaw, Poland

open access

Vol 90, No 1 (2019)
ORIGINAL PAPERS Gynecology
Published online: 2019-01-31

Abstract

Objectives: To evaluate the effects of a combined Myo-inositol (MI) and D-chiro-inositol (DCI) therapy on the hormonal and metabolic parameters of women with PCOS. Prospective clinical study. Clinical Study registration number — EUPAS25705

Material and methods: Seventy women diagnosed with PCOS according to the Rotterdam criteria were enrolled in this study. Patients received a combined therapy of one tablet that contained 550 mg of inositol (myo-inositol (MI) and D-chiro-inositol (DCI) in a ratio of 10:1) twice a day for 6 months. At each of 3 visits, the body weight, height and BMI were all recorded; and serum levels of free testosterone (fT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and glucose with insulin during standard OGTT (75 g) were measured. Also at each visit, transvaginal ultrasonography and skin condition assessments were performed.

Results: Significant body weight reduction and decreases in fT, FSH, LH and insulin levels, as well as significant increase of serum SHBG concentrations were observed. Serum glucose levels during OGTT decreased after 6 months of treatment. Also, skin conditions improved after only three months of treatment.

Conclusions: Combination of MI and DCI in a ratio 10:1 seems to be efficient in improving both metabolic and hormonal parameters in patients with PCOS.  

Abstract

Objectives: To evaluate the effects of a combined Myo-inositol (MI) and D-chiro-inositol (DCI) therapy on the hormonal and metabolic parameters of women with PCOS. Prospective clinical study. Clinical Study registration number — EUPAS25705

Material and methods: Seventy women diagnosed with PCOS according to the Rotterdam criteria were enrolled in this study. Patients received a combined therapy of one tablet that contained 550 mg of inositol (myo-inositol (MI) and D-chiro-inositol (DCI) in a ratio of 10:1) twice a day for 6 months. At each of 3 visits, the body weight, height and BMI were all recorded; and serum levels of free testosterone (fT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and glucose with insulin during standard OGTT (75 g) were measured. Also at each visit, transvaginal ultrasonography and skin condition assessments were performed.

Results: Significant body weight reduction and decreases in fT, FSH, LH and insulin levels, as well as significant increase of serum SHBG concentrations were observed. Serum glucose levels during OGTT decreased after 6 months of treatment. Also, skin conditions improved after only three months of treatment.

Conclusions: Combination of MI and DCI in a ratio 10:1 seems to be efficient in improving both metabolic and hormonal parameters in patients with PCOS.  

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Keywords

inositol; PCOS; OGTT; MI DCI ratio

About this article
Title

Metabolic and hormonal effects of a combined Myo-inositol and d-chiro-inositol therapy on patients with polycystic ovary syndrome (PCOS)

Journal

Ginekologia Polska

Issue

Vol 90, No 1 (2019)

Article type

Research paper

Pages

7-10

Published online

2019-01-31

Page views

7946

Article views/downloads

4976

DOI

10.5603/GP.2019.0002

Pubmed

30756365

Bibliographic record

Ginekol Pol 2019;90(1):7-10.

Keywords

inositol
PCOS
OGTT
MI DCI ratio

Authors

Marcin Januszewski
Tadeusz Issat
Alicja A Jakimiuk
Malgorzata Santor-Zaczynska
Artur J Jakimiuk

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