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The role of the βKlotho gene in uterine endometrial cancer
Affiliations- Clinical Department of Oncological Gynecology, II Department of Gynecology and Obstetrics, Medical University of Lodz, Poland, Poland
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Abstract
Objectives: Endometrial cancer is the most common cancer of the female genital organs in developed countries, accounting for approximately 50% of all gynecological cancers. The Klotho gene was discovered in 1997 as an anti-aging gene that, when overexpressed, may extend the lifespan, but when disrupted, may be a factor responsible for premature aging syndrome. The aim of the study is to assess the relationship between the clinical and pathological features of endometrial cancer and βKlotho gene expression.
Material and methods: The expression of βKlotho gene was studied in 138 cases of endometrioid endometrial carcinoma specimens using Real Time PCR reaction in RNA isolated tissue samples by commercial tests. The expression profile was correlated with the clinicopathological characteristics of endometrial carcinoma. The chi-square independence test and Fisher’s test for four-field tables were used to assess the statistical significance of the observed relationships.
Results: Significant relationships were found between βKlotho gene expression and FIGO clinical stage, the degree of histological differentiation and the presence of metastases in the lymph nodes. Higher levels of gene expression correlate with lower degrees of clinical staging according to FIGO, the presence of highly-differentiated endometrial cancer (G1) and the absence of lymph node metastases.
Conclusions: The βKlotho gene expression might be involved in endometrioid endometrial cancer tumorgenesis. The
βKlotho may in future be used as an useful indicator for endometrial cancer, although further studies are needed.
Abstract
Objectives: Endometrial cancer is the most common cancer of the female genital organs in developed countries, accounting for approximately 50% of all gynecological cancers. The Klotho gene was discovered in 1997 as an anti-aging gene that, when overexpressed, may extend the lifespan, but when disrupted, may be a factor responsible for premature aging syndrome. The aim of the study is to assess the relationship between the clinical and pathological features of endometrial cancer and βKlotho gene expression.
Material and methods: The expression of βKlotho gene was studied in 138 cases of endometrioid endometrial carcinoma specimens using Real Time PCR reaction in RNA isolated tissue samples by commercial tests. The expression profile was correlated with the clinicopathological characteristics of endometrial carcinoma. The chi-square independence test and Fisher’s test for four-field tables were used to assess the statistical significance of the observed relationships.
Results: Significant relationships were found between βKlotho gene expression and FIGO clinical stage, the degree of histological differentiation and the presence of metastases in the lymph nodes. Higher levels of gene expression correlate with lower degrees of clinical staging according to FIGO, the presence of highly-differentiated endometrial cancer (G1) and the absence of lymph node metastases.
Conclusions: The βKlotho gene expression might be involved in endometrioid endometrial cancer tumorgenesis. The
βKlotho may in future be used as an useful indicator for endometrial cancer, although further studies are needed.
Keywords
endometrial cancer; Beta Klotho gene
About this articleTitle
The role of the βKlotho gene in uterine endometrial cancer
Journal
Issue
Article type
Research paper
Pages
563-567
Published online
2018-10-31
Page views
1731
Article views/downloads
1154
DOI
Pubmed
Bibliographic record
Ginekol Pol 2018;89(10):563-567.
Keywords
endometrial cancer
Beta Klotho gene
Authors
Katarzyna Monika Wójcik-Krowiranda
Sylwia Szczepaniec
Andrzej Bieńkiewicz
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