open access

Vol 89, No 10 (2018)
Research paper
Published online: 2018-10-31
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The role of the βKlotho gene in uterine endometrial cancer

Katarzyna Monika Wójcik-Krowiranda1, Sylwia Szczepaniec1, Andrzej Bieńkiewicz1
DOI: 10.5603/GP.a2018.0096
·
Pubmed: 30393845
·
Ginekol Pol 2018;89(10):563-567.
Affiliations
  1. Clinical Department of Oncological Gynecology, II Department of Gynecology and Obstetrics, Medical University of Lodz, Poland, Poland

open access

Vol 89, No 10 (2018)
ORIGINAL PAPERS Gynecology
Published online: 2018-10-31

Abstract

Objectives: Endometrial cancer is the most common cancer of the female genital organs in developed countries, accounting for approximately 50% of all gynecological cancers. The Klotho gene was discovered in 1997 as an anti-aging gene that, when overexpressed, may extend the lifespan, but when disrupted, may be a factor responsible for premature aging syndrome. The aim of the study is to assess the relationship between the clinical and pathological features of endometrial cancer and βKlotho gene expression.
Material and methods: The expression of βKlotho gene was studied in 138 cases of endometrioid endometrial carcinoma specimens using Real Time PCR reaction in RNA isolated tissue samples by commercial tests. The expression profile was correlated with the clinicopathological characteristics of endometrial carcinoma. The chi-square independence test and Fisher’s test for four-field tables were used to assess the statistical significance of the observed relationships.
Results: Significant relationships were found between βKlotho gene expression and FIGO clinical stage, the degree of histological differentiation and the presence of metastases in the lymph nodes. Higher levels of gene expression correlate with lower degrees of clinical staging according to FIGO, the presence of highly-differentiated endometrial cancer (G1) and the absence of lymph node metastases.
Conclusions: The βKlotho gene expression might be involved in endometrioid endometrial cancer tumorgenesis. The
βKlotho may in future be used as an useful indicator for endometrial cancer, although further studies are needed.

Abstract

Objectives: Endometrial cancer is the most common cancer of the female genital organs in developed countries, accounting for approximately 50% of all gynecological cancers. The Klotho gene was discovered in 1997 as an anti-aging gene that, when overexpressed, may extend the lifespan, but when disrupted, may be a factor responsible for premature aging syndrome. The aim of the study is to assess the relationship between the clinical and pathological features of endometrial cancer and βKlotho gene expression.
Material and methods: The expression of βKlotho gene was studied in 138 cases of endometrioid endometrial carcinoma specimens using Real Time PCR reaction in RNA isolated tissue samples by commercial tests. The expression profile was correlated with the clinicopathological characteristics of endometrial carcinoma. The chi-square independence test and Fisher’s test for four-field tables were used to assess the statistical significance of the observed relationships.
Results: Significant relationships were found between βKlotho gene expression and FIGO clinical stage, the degree of histological differentiation and the presence of metastases in the lymph nodes. Higher levels of gene expression correlate with lower degrees of clinical staging according to FIGO, the presence of highly-differentiated endometrial cancer (G1) and the absence of lymph node metastases.
Conclusions: The βKlotho gene expression might be involved in endometrioid endometrial cancer tumorgenesis. The
βKlotho may in future be used as an useful indicator for endometrial cancer, although further studies are needed.

Get Citation

Keywords

endometrial cancer; Beta Klotho gene

About this article
Title

The role of the βKlotho gene in uterine endometrial cancer

Journal

Ginekologia Polska

Issue

Vol 89, No 10 (2018)

Article type

Research paper

Pages

563-567

Published online

2018-10-31

DOI

10.5603/GP.a2018.0096

Pubmed

30393845

Bibliographic record

Ginekol Pol 2018;89(10):563-567.

Keywords

endometrial cancer
Beta Klotho gene

Authors

Katarzyna Monika Wójcik-Krowiranda
Sylwia Szczepaniec
Andrzej Bieńkiewicz

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