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The powerful association of angiotensin-converting enzyme insertion/deletion polymorphism and idiopathic recurrent pregnancy loss
Affiliations- Department of Medical Genetics, Faculty of Medicine, University of Harran, 63000 Sanliurfa, Türkiye
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Abstract
Objectives: Idiopathic recurrent pregnancy loss (IRPL) is one of the most troublesome complications of pregnancy. Several researches were also conducted to search the possible association with ACE I/D polymorphism and IRPL. In the light of these reports, this case-control study was investigated to genotypes and alleles of ACE I/D polymorphism in IRPL group and control group.
Material and methods: Overall, 1176 subjects (1007 cases, 169 controls) were investigated. Allele genotype distributions were determined by PCR method in both groups. Differences in genotype and allele frequencies between groups were investigated by Pearson chi-square tests. The odds ratio (OR) and 95% confidence intervals (95% CI) were also determined.
Results: For the ACE I/D polymorphism I and D allele frequencies were in the control and case groups respectively; 49.4 and 41.6%, 50.6 and 58.4%. The genotypes of ACE for I/D observed in control and case group respectively were as follows; II (27.2 and 17.9), ID (44.4 and 47.4) and DD (28.4 and 34.7). Regarding the distribution of D allele and genotypes containing D allele, we observed significant statistical differences between case and control groups.
Conclusions: Our results showed that the ACE I/D polymorphism was associated with IRPL, and that women that carried DD or ID genotypes had a 72% elevated risk of developing IRPL than women with the II genotype (OR (95% CI): 1.72 (1.181–2.5)). This odds ratio was found to be 1.61 in a case-control study and 1.28 in a meta-analysis study compiling 11 separate studies, which is consistent with our study data.
Abstract
Objectives: Idiopathic recurrent pregnancy loss (IRPL) is one of the most troublesome complications of pregnancy. Several researches were also conducted to search the possible association with ACE I/D polymorphism and IRPL. In the light of these reports, this case-control study was investigated to genotypes and alleles of ACE I/D polymorphism in IRPL group and control group.
Material and methods: Overall, 1176 subjects (1007 cases, 169 controls) were investigated. Allele genotype distributions were determined by PCR method in both groups. Differences in genotype and allele frequencies between groups were investigated by Pearson chi-square tests. The odds ratio (OR) and 95% confidence intervals (95% CI) were also determined.
Results: For the ACE I/D polymorphism I and D allele frequencies were in the control and case groups respectively; 49.4 and 41.6%, 50.6 and 58.4%. The genotypes of ACE for I/D observed in control and case group respectively were as follows; II (27.2 and 17.9), ID (44.4 and 47.4) and DD (28.4 and 34.7). Regarding the distribution of D allele and genotypes containing D allele, we observed significant statistical differences between case and control groups.
Conclusions: Our results showed that the ACE I/D polymorphism was associated with IRPL, and that women that carried DD or ID genotypes had a 72% elevated risk of developing IRPL than women with the II genotype (OR (95% CI): 1.72 (1.181–2.5)). This odds ratio was found to be 1.61 in a case-control study and 1.28 in a meta-analysis study compiling 11 separate studies, which is consistent with our study data.
Keywords
ACE, polymorphism, recurrent miscarriages, pregnancy loss
About this articleTitle
The powerful association of angiotensin-converting enzyme insertion/deletion polymorphism and idiopathic recurrent pregnancy loss
Journal
Issue
Article type
Research paper
Pages
573-576
Published online
2018-10-31
Page views
1829
Article views/downloads
1112
DOI
Pubmed
Bibliographic record
Ginekol Pol 2018;89(10):573-576.
Keywords
ACE
polymorphism
recurrent miscarriages
pregnancy loss
Authors
Evren Gumus
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