open access

Vol 89, No 7 (2018)
Research paper
Published online: 2018-07-31
Get Citation

Maternal hypoglycaemia on the 50 g oral glucose challenge test — evaluation of obstetric and neonatal outcomes

Mehmet Şükrü Budak1, Eşref Araç12
DOI: 10.5603/GP.a2018.0063
·
Pubmed: 30091446
·
Ginekol Pol 2018;89(7):370-374.
Affiliations
  1. University of Health Sciences Diyarbakır Gazi Yaşargil Training and Research Hospital Department of Obstetrics and Gynecology, TR 21500 Diyarbakır, Turkey
  2. Health Sciences University Diyarbakır Gazi Yaşargil Training and Research Hospital, Department of Internal Medicine, Diyarbakır, Turkey

open access

Vol 89, No 7 (2018)
ORIGINAL PAPERS Obstetrics
Published online: 2018-07-31

Abstract

Objectives: To discuss obstetric and neonatal outcomes of maternal hypoglycaemia observed after the 50 g oral glucose challenge test.

Material and methods: A retrospective evaluation was made of the results of patients at 24–28 weeks gestation of a live singleton pregnancy who underwent a 50 g OGCT at the Health Sciences University Gazi Yaşargil Training and Research Hos­pital, between September 2016 and August 2017. In the 50 g OGCT, 1-hour blood glucose results were divided into Low OGCT (< 90 mg/dL) and Normal OGCT (90–139 mg/dL). The groups were compared in respect of obstetrics and neonatal outcomes.

Results: Of 2623 pregnant patients applied with the 50 g OGCT, blood glucose was < 140 mg/dL in 77.16% (n = 2024), with 11.9% (n = 312) in the Low OGCT group, and the remaining 65.26% (n = 1712) in the Normal OGCT group. Based on the comparison of the groups, the SGA rate was 7% in the Low OGCT group and 4% in the Normal OGCT group; the 5th minute APGAR score was < 7 in 2% of the Low OGCT group and in 1% of the Normal OGCT group, while caesarean section rates were 25% and 32% respectively (p < 0.05).

Conclusions: The results of the study showed a significant association between maternal hypoglycaemia and increased SGA rate, decreased 5-minute APGAR scores and reduced caesarean section rates, and this relationship should be confirmed with further comprehensive studies.

Abstract

Objectives: To discuss obstetric and neonatal outcomes of maternal hypoglycaemia observed after the 50 g oral glucose challenge test.

Material and methods: A retrospective evaluation was made of the results of patients at 24–28 weeks gestation of a live singleton pregnancy who underwent a 50 g OGCT at the Health Sciences University Gazi Yaşargil Training and Research Hos­pital, between September 2016 and August 2017. In the 50 g OGCT, 1-hour blood glucose results were divided into Low OGCT (< 90 mg/dL) and Normal OGCT (90–139 mg/dL). The groups were compared in respect of obstetrics and neonatal outcomes.

Results: Of 2623 pregnant patients applied with the 50 g OGCT, blood glucose was < 140 mg/dL in 77.16% (n = 2024), with 11.9% (n = 312) in the Low OGCT group, and the remaining 65.26% (n = 1712) in the Normal OGCT group. Based on the comparison of the groups, the SGA rate was 7% in the Low OGCT group and 4% in the Normal OGCT group; the 5th minute APGAR score was < 7 in 2% of the Low OGCT group and in 1% of the Normal OGCT group, while caesarean section rates were 25% and 32% respectively (p < 0.05).

Conclusions: The results of the study showed a significant association between maternal hypoglycaemia and increased SGA rate, decreased 5-minute APGAR scores and reduced caesarean section rates, and this relationship should be confirmed with further comprehensive studies.

Get Citation

Keywords

oral glucose challenge test, hypoglycaemia, obstetric outcome

About this article
Title

Maternal hypoglycaemia on the 50 g oral glucose challenge test — evaluation of obstetric and neonatal outcomes

Journal

Ginekologia Polska

Issue

Vol 89, No 7 (2018)

Article type

Research paper

Pages

370-374

Published online

2018-07-31

DOI

10.5603/GP.a2018.0063

Pubmed

30091446

Bibliographic record

Ginekol Pol 2018;89(7):370-374.

Keywords

oral glucose challenge test
hypoglycaemia
obstetric outcome

Authors

Mehmet Şükrü Budak
Eşref Araç

References (19)
  1. Jovanovic L, Pettitt DJ. Gestational diabetes mellitus. JAMA. 2001; 286(20): 2516–2518.
  2. Casey BM, Lucas MJ, Mcintire DD, et al. Pregnancy outcomes in women with gestational diabetes compared with the general obstetric population. Obstet Gynecol. 1997; 90(6): 869–873.
  3. Metzger BE, Lowe LP, Dyer AR, et al. HAPO Study Cooperative Research Group. Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008; 358(19): 1991–2002.
  4. American College of Obstetricians and Gynecologists Committee on Practice Bulletins-Obstetrics.ACOG Practice Bulletin.Clinical managment guidlelines for ostetrrician-gynecologists. September Gynecol. 2001; 98(30): 525–538.
  5. Kjos SL, Buchanan TA. Gestational diabetes mellitus. N Engl J Med. 1999; 341(23): 1749–1756.
  6. Berger H, Gagnon R, Sermer M. Diabetes in Pregnancy. Journal of Obstetrics and Gynaecology Canada. 2016; 38(7): 667–679.e1.
  7. van Leeuwen M, Louwerse MD, Opmeer BC, et al. Glucose challenge test for detecting gestational diabetes mellitus: a systematic review. BJOG. 2012; 119(4): 393–401.
  8. Melamed N, Hiersch L, Peled Y, et al. The association between low 50 g glucose challenge test result and fetal growth restriction. J Matern Fetal Neonatal Med. 2013; 26(11): 1107–1111.
  9. Shinohara S, Hirai M, Hirata S, et al. Relation between low 50-g glucose challenge test results and small-for-gestational-age infants. J Obstet Gynaecol Res. 2015; 41(11): 1752–1756.
  10. Ma KK, Mele L, Landon MB, et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. The obstetric and neonatal implications of a low value on the 50-g glucose screening test. Am J Perinatol. 2013; 30(9): 715–722.
  11. Coustan DR, Carpenter MW, Carpenter MW, et al. Criteria for screening tests for gestational diabetes. Am J Obstet Gynecol. 1982; 144(7): 768–773.
  12. American College of Obstetricians and Gynecologists. ACOG Practice bulletin no. 134: fetal growth restriction. Obstet Gynecol. 2013; 121(5): 1122–1133.
  13. Shinohara S, Uchida Y, Hirai M, et al. Relationship between maternal hypoglycaemia and small-for-gestational-age infants according to maternal weight status: a retrospective cohort study in two hospitals. BMJ Open. 2016; 6(12): e013749.
  14. Kwon H, Lee J, Lee BW, et al. The Association Between Low 50 g Glucose Challenge Test Values and Adverse Pregnancy Outcomes. J Womens Health (Larchmt). 2018; 27(6): 801–807.
  15. Limesand SW, Rozance PJ, Brown LD, et al. Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep. Am J Physiol Endocrinol Metab. 2009; 296(4): E879–E887.
  16. Feinberg JH, Magann EF, Morrison JC, et al. Does maternal hypoglycemia during screening glucose assessment identify a pregnancy at-risk for adverse perinatal outcome? J Perinatol. 2005; 25(8): 509–513.
  17. McIntire DD, Bloom SL, Casey BM, et al. Birth weight in relation to morbidity and mortality among newborn infants. N Engl J Med. 1999; 340(16): 1234–1238.
  18. Roberts CL, Bell JC, Ford JB, et al. The accuracy of reporting of the hypertensive disorders of pregnancy in population health data. Hypertens Pregnancy. 2008; 27(3): 285–297.
  19. Bateman BT, Bansil P, Hernandez-Diaz S, et al. Prevalence, trends, and outcomes of chronic hypertension: a nationwide sample of delivery admissions. Am J Obstet Gynecol. 2012; 206(2): 134.e1–134.e8.

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl