open access

Vol 88, No 11 (2017)
Guidelines / Expert consensus
Published online: 2017-11-30
Get Citation

Folate supplementation during the preconception period, pregnancy and puerperium. Polish Society of Gynecologists and Obstetricians Guidelines

Dorota Bomba-Opoń, Lidia Hirnle, Jarosław Kalinka, Agnieszka Seremak-Mrozikiewicz
DOI: 10.5603/GP.a2017.0113
Pubmed: 29303218
Ginekol Pol 2017;88(11):633-636.

open access

Vol 88, No 11 (2017)
Published online: 2017-11-30


Not available


Not available
Get Citation
About this article

Folate supplementation during the preconception period, pregnancy and puerperium. Polish Society of Gynecologists and Obstetricians Guidelines


Ginekologia Polska


Vol 88, No 11 (2017)

Article type

Guidelines / Expert consensus



Published online


Page views


Article views/downloads






Bibliographic record

Ginekol Pol 2017;88(11):633-636.


Dorota Bomba-Opoń
Lidia Hirnle
Jarosław Kalinka
Agnieszka Seremak-Mrozikiewicz

References (30)
  1. Institute of Medicine Food and Nutrition Board.Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academies Press, Washington, DC: : 1998.
  2. Bean LJH, Allen EG, Tinker SW, et al. Lack of maternal folic acid supplementation is associated with heart defects in Down syndrome: a report from the National Down Syndrome Project. Birth Defects Res A Clin Mol Teratol. 2011; 91(10): 885–893.
  3. Li Z, Ye R, Zhang Le, et al. Folic acid supplementation during early pregnancy and the risk of gestational hypertension and preeclampsia. Hypertension. 2013; 61(4): 873–879.
  4. Wen SWu, Guo Y, Rodger M, et al. Folic Acid Supplementation in Pregnancy and the Risk of Pre-Eclampsia-A Cohort Study. PLoS One. 2016; 11(2): e0149818.
  5. Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med. 1992; 327(26): 1832–1835.
  6. Mulinare J, Cordero JF, Erickson JD, et al. Periconceptional use of multivitamins and the occurrence of neural tube defects. JAMA. 1988; 260(21): 3141–3145.
  7. Milunsky A, Jick H, Jick SS, et al. Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA. 1989; 262(20): 2847–2852.
  8. Centers for Disease Control (CDC). Use of folic acid for prevention of spina bifida and other neural tube defects--1983-1991. MMWR Morb Mortal Wkly Rep. 1991; 40(30): 513–516.
  9. Bower C, Stanley FJ. Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia. Med J Aust. 1989; 150(11): 613–619.
  10. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet. 1991; 338(8760): 131–137.
  11. Atta CAM, Fiest KM, Frolkis AD, et al. Global Birth Prevalence of Spina Bifida by Folic Acid Fortification Status: A Systematic Review and Meta-Analysis. Am J Public Health. 2016; 106(1): e24–e34.
  12. Boulet SL, Yang Q, Mai C, et al. National Birth Defects Prevention Network. Trends in the postfortification prevalence of spina bifida and anencephaly in the United States. Birth Defects Res A Clin Mol Teratol. 2008; 82(7): 527–532.
  13. Shaw GM, O'Malley CD, Wasserman CR, et al. Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. Am J Med Genet. 1995; 59(4): 536–545.
  14. Czeizel AE, Dobó M, Vargha P, et al. Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation. Am J Med Genet. 1996; 62(2): 179–183, doi: 10.1002/(SICI)1096-8628(19960315)62:2<179::AID-AJMG12>3.0.CO;2-L.
  15. Yazdy MM, Honein MA, Xing J. Reduction in orofacial clefts following folic acid fortification of the U.S. grain supply. Birth Defects Res A Clin Mol Teratol. 2007; 79(1): 16–23.
  16. Norsworthy B, Skeaff CM, Adank C, et al. Effects of once-a-week or daily folic acid supplementation on red blood cell folate concentrations in women. Eur J Clin Nutr. 2004; 58(3): 548–54.
  17. Hursthouse NA, Gray AR, Miller JC, et al. Folate status of reproductive age women and neural tube defect risk: the effect of long-term folic acid supplementation at doses of 140 µg and 400 µg per day. Nutrients. 2011; 3(1): 49–62.
  18. Paul L, Selhub J. Interaction between excess folate and low vitamin B12 status. Mol Aspects Med. 2017; 53: 43–47.
  19. Selhub J, Rosenberg IH. Excessive folic acid intake and relation to adverse health outcome. Biochimie. 2016; 126: 71–78.
  20. Yajnik CS, Deshpande SS, Jackson AA, et al. Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study. Diabetologia. 2008; 51(1): 29–38.
  21. Parker SE, Yazdy MM, Tinker SC, et al. The impact of folic acid intake on the association among diabetes mellitus, obesity, and spina bifida. Am J Obstet Gynecol. 2013; 209(3): 239.e1–239.e8.
  22. Zhang Q, Li S, Li L, et al. Metformin Treatment and Homocysteine: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2016; 8(12).
  23. Shankar P, Boylan M, Sriram K. Micronutrient deficiencies after bariatric surgery. Nutrition. 2010; 26(11-12): 1031–1037.
  24. Wang M, Wang ZP, Gao LJ, et al. Maternal body mass index and the association between folic acid supplements and neural tube defects. Acta Paediatr. 2013; 102(9): 908–913.
  25. McMahon DM, Liu J, Zhang H, et al. Maternal obesity, folate intake, and neural tube defects in offspring. Birth Defects Res A Clin Mol Teratol. 2013; 97(2): 115–122.
  26. Jędrzejczak J, Bomba-Opoń D, Jakiel G, et al. Managing epilepsy in women of childbearing age - Polish Society of Epileptology and Polish Gynecological Society Guidelines. Ginekol Pol. 2017; 88(5): 278–284.
  27. Tsang BL, Devine OJ, Cordero AM, et al. Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies. Am J Clin Nutr. 2015; 101(6): 1286–1294.
  28. Prinz-Langenohl R, Brämswig S, Tobolski O, et al. [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->T polymorphism of methylenetetrahydrofolate reductase. Br J Pharmacol. 2009; 158(8): 2014–2021.
  29. Grosse SD, Collins JS. Folic acid supplementation and neural tube defect recurrence prevention. Birth Defects Res A Clin Mol Teratol. 2007; 79(11): 737–742.
  30. Arth A, Tinker S, Moore C, et al. Centers for Disease Control and Prevention. Supplement use and other characteristics among pregnant women with a previous pregnancy affected by a neural tube defect - United States, 1997-2009. MMWR Morb Mortal Wkly Rep. 2015; 64(1): 6–9.


Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: