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Vol 88, No 12 (2017)
Research paper
Published online: 2017-12-29
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Dydrogesterone has no effect on uterine fibroids when used to prevent miscarriage in pregnant women with uterine fibroids

Shan Wang1, Xie-Tong Wang1, Rui-Hua Liu2, Ming Liu1, Yu-Rui Wu1, Xiao-Yan Huang1, Na Zhao, Yu-Lan Mu1
DOI: 10.5603/GP.a2017.0121
·
Pubmed: 29303226
·
Ginekol Pol 2017;88(12):679-685.
Affiliations
  1. Department of Obstetrics and Gynecology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China
  2. Ultrasound room,Yantai Yuhuangding Hospital, Yantai, China

open access

Vol 88, No 12 (2017)
ORIGINAL PAPERS Obstetrics
Published online: 2017-12-29

Abstract

Objectives: To analyse the effect of dydrogesterone use during pregnancy on uterine fibroids, pregnancy complications, and pregnancy outcome. Material and methods: In all, 372 pregnant women with uterine fibroids who were treated at the Affiliated Provincial Hospital of Shandong University were included in this study. Thirty-three of these women received dydrogesterone and constituted the treatment group, and the 27 women who were found to have uterine fibroids during the first trimester but did not receive intervention to prevent miscarriage composed the control group. The changes in uterine fibroids before and after pregnancy and the pregnancy complications were recorded; immunohistochemistry was used to detect the expression of progesterone receptor (PR) and proliferation- and apoptosis-related proteins in the uterine fibroid tissue. Results: No significant difference was observed in the change in uterine fibroid volume during pregnancy between the treatment group and the control group (p > 0.05). The percentage of uterine fibroids with red degeneration was lower in the treatment group than in the control group, but the difference was not statistically significant. No significant difference was observed in newborn weight, height, Apgar score, threatened miscarriage, or premature birth, among other characteristics, between the two groups (p > 0.05). Immunohistochemistry showed no significant difference in the expression of PR, cyclinD1, insulin-like growth factor (IGF1), or B-cell lymphoma 2 (Bcl2) between the two groups. Conclusions: The use of dydrogesterone during pregnancy has no significant effect on uterine fibroids, pregnancy progression, or pregnancy outcomes in pregnant patients with uterine fibroids.

Abstract

Objectives: To analyse the effect of dydrogesterone use during pregnancy on uterine fibroids, pregnancy complications, and pregnancy outcome. Material and methods: In all, 372 pregnant women with uterine fibroids who were treated at the Affiliated Provincial Hospital of Shandong University were included in this study. Thirty-three of these women received dydrogesterone and constituted the treatment group, and the 27 women who were found to have uterine fibroids during the first trimester but did not receive intervention to prevent miscarriage composed the control group. The changes in uterine fibroids before and after pregnancy and the pregnancy complications were recorded; immunohistochemistry was used to detect the expression of progesterone receptor (PR) and proliferation- and apoptosis-related proteins in the uterine fibroid tissue. Results: No significant difference was observed in the change in uterine fibroid volume during pregnancy between the treatment group and the control group (p > 0.05). The percentage of uterine fibroids with red degeneration was lower in the treatment group than in the control group, but the difference was not statistically significant. No significant difference was observed in newborn weight, height, Apgar score, threatened miscarriage, or premature birth, among other characteristics, between the two groups (p > 0.05). Immunohistochemistry showed no significant difference in the expression of PR, cyclinD1, insulin-like growth factor (IGF1), or B-cell lymphoma 2 (Bcl2) between the two groups. Conclusions: The use of dydrogesterone during pregnancy has no significant effect on uterine fibroids, pregnancy progression, or pregnancy outcomes in pregnant patients with uterine fibroids.

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Keywords

pregnancy, uterine fibroids, dydrogesterone, miscarriage

About this article
Title

Dydrogesterone has no effect on uterine fibroids when used to prevent miscarriage in pregnant women with uterine fibroids

Journal

Ginekologia Polska

Issue

Vol 88, No 12 (2017)

Article type

Research paper

Pages

679-685

Published online

2017-12-29

Page views

1813

Article views/downloads

5153

DOI

10.5603/GP.a2017.0121

Pubmed

29303226

Bibliographic record

Ginekol Pol 2017;88(12):679-685.

Keywords

pregnancy
uterine fibroids
dydrogesterone
miscarriage

Authors

Shan Wang
Xie-Tong Wang
Rui-Hua Liu
Ming Liu
Yu-Rui Wu
Xiao-Yan Huang
Na Zhao
Yu-Lan Mu

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