open access

Vol 88, No 10 (2017)
Review paper
Published online: 2017-10-31
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Novel biomarkers of overactive bladder syndrome

Andrzej Franciszek Wróbel1, Tomasz Kluz2, Grzegorz Surkont3, Edyta Wlaźlak3, Paweł Skorupski1, Aleksandra Filipczak1, Tomasz Rechberger1
·
Pubmed: 29192418
·
Ginekol Pol 2017;88(10):568-573.
Affiliations
  1. Second Department of Gynecology, Medical University of Lublin,, Jaczewskiego 8, PL 20-090 Lublin, Poland, 20-090 Lublin, Poland
  2. Department of Obstetrics and Gynecology, Fryderyk Chopin University Hospital No 1, Faculty of Medicine, Rzeszow University, Chopina 2, PL 35-055 Rzeszów, Poland, 35-055 Rzeszów, Poland
  3. Department of Operative Gynecology and Gynecologic Oncology, Ist Department of Gynecology and Obstetrics, Medical University of Łódź, Wileńska 37, 94-029 Łódź, Poland, 94-029 Łódź, Poland

open access

Vol 88, No 10 (2017)
REVIEW PAPERS Gynecology
Published online: 2017-10-31

Abstract

The social aspect of overactive bladder syndrome (OAB) and the lack of objective diagnostic methods for this syndrome have spurred research into its potential biomarkers which can constitute useful diagnostic tools, while also allowing the evaluation of the intensity of clinical symptoms and the efficacy of implemented pharmacotherapy in OAB patients. Due to the complex etiopathogenesis of this syndrome, the researchers are seeking biomarkers connected with inflammation or nerve growth. The aim of this review was to analyse the latest literature data regarding potential biomarkers in OAB. The most promising opportunities are connected with the diagnostic use of the nerve growth factor (NGF), the brain derived neurotrophic factor (BDNF), C-reactive protein (CRP), prostaglandins and cytokines. Despite the most promising results to date having been obtained with regards to neurotrophic factors, it seems that, at the moment, none of these meets the criteria for becoming an isolated OAB marker. It is also suggested that the combined use of several biomarkers will facilitate obtaining the appropriate level of specificity and selectivity to allow their use in clinical practice.

Abstract

The social aspect of overactive bladder syndrome (OAB) and the lack of objective diagnostic methods for this syndrome have spurred research into its potential biomarkers which can constitute useful diagnostic tools, while also allowing the evaluation of the intensity of clinical symptoms and the efficacy of implemented pharmacotherapy in OAB patients. Due to the complex etiopathogenesis of this syndrome, the researchers are seeking biomarkers connected with inflammation or nerve growth. The aim of this review was to analyse the latest literature data regarding potential biomarkers in OAB. The most promising opportunities are connected with the diagnostic use of the nerve growth factor (NGF), the brain derived neurotrophic factor (BDNF), C-reactive protein (CRP), prostaglandins and cytokines. Despite the most promising results to date having been obtained with regards to neurotrophic factors, it seems that, at the moment, none of these meets the criteria for becoming an isolated OAB marker. It is also suggested that the combined use of several biomarkers will facilitate obtaining the appropriate level of specificity and selectivity to allow their use in clinical practice.

Get Citation

Keywords

biomarker, overactive bladder, diagnosis

About this article
Title

Novel biomarkers of overactive bladder syndrome

Journal

Ginekologia Polska

Issue

Vol 88, No 10 (2017)

Article type

Review paper

Pages

568-573

Published online

2017-10-31

Page views

2182

Article views/downloads

2081

DOI

10.5603/GP.a2017.0102

Pubmed

29192418

Bibliographic record

Ginekol Pol 2017;88(10):568-573.

Keywords

biomarker
overactive bladder
diagnosis

Authors

Andrzej Franciszek Wróbel
Tomasz Kluz
Grzegorz Surkont
Edyta Wlaźlak
Paweł Skorupski
Aleksandra Filipczak
Tomasz Rechberger

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