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Strategy and early results of treatment of advanced cervical cancer patients with synchronous cancers observed in PET-CT imaging
Affiliations- Department of Radiotherapy and Oncological Gynecology, Greater Poland Cancer Center, Poznań, Poland, ul. Garbary 15, 61-866 Poznań, Poland
- Department of Nuclear Medicine, Greater Poland Cancer Center, Poznań, Poland, ul. Garbary 15, 61-866 Poznań, Poland
- Department of Electroradiology, Poznań University of Medical Sciences, Poznań, Poland, ul. Garbary 15, 61-866 Poznań, Poland
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Abstract
Objectives: The aim of this study was to present strategy and early results of treatment of advanced cervical cancer patients with synchronous cancers observed in PET-CT imaging, treated at the Greater Poland Cancer Center.
Material and methods: The study included a group of 200 patients with diagnosed stage IIB-IIIB cervical cancer who received PET-CT for the purpose of radiotherapy treatment planning.
Results: Among our study group, four patients (2%) were found to have a synchronous cancer. Two of the cases were diagnosed as breast cancer. However, cancers diagnosed in the other two patients were head and neck malignancies — hypopharyngeal and laryngeal cancer. The choice of an optimal therapeutic approach requires taking into account characteristics of particular malignancies, their stage and histopathology. The whole therapy included radiotherapy of cervical cancer with various combinations of systemic treatment, radiotherapy or surgery of synchronous cancer. According to treatment results, patients diagnosed with breast cancer and hypopharyngeal cancer achieved complete remission of both primary and secondary tumour. Patient diagnosed with laryngeal malignancy, despite achieving complete remission of cervical cancer, finished radiotherapy of the synchronous cancer at a palliative dose.
Conclusions: The growing availability of PET-CT and other imaging methods in cancer diagnosis will increase the number of diagnosed synchronous cancers. Second primary cancers are often detected at an early stage, where radical treatment can be performed for both primary and secondary tumour. However, treatment of such complicated clinical cases as synchronous cancers should be carried out by multidisciplinary teams.
Abstract
Objectives: The aim of this study was to present strategy and early results of treatment of advanced cervical cancer patients with synchronous cancers observed in PET-CT imaging, treated at the Greater Poland Cancer Center.
Material and methods: The study included a group of 200 patients with diagnosed stage IIB-IIIB cervical cancer who received PET-CT for the purpose of radiotherapy treatment planning.
Results: Among our study group, four patients (2%) were found to have a synchronous cancer. Two of the cases were diagnosed as breast cancer. However, cancers diagnosed in the other two patients were head and neck malignancies — hypopharyngeal and laryngeal cancer. The choice of an optimal therapeutic approach requires taking into account characteristics of particular malignancies, their stage and histopathology. The whole therapy included radiotherapy of cervical cancer with various combinations of systemic treatment, radiotherapy or surgery of synchronous cancer. According to treatment results, patients diagnosed with breast cancer and hypopharyngeal cancer achieved complete remission of both primary and secondary tumour. Patient diagnosed with laryngeal malignancy, despite achieving complete remission of cervical cancer, finished radiotherapy of the synchronous cancer at a palliative dose.
Conclusions: The growing availability of PET-CT and other imaging methods in cancer diagnosis will increase the number of diagnosed synchronous cancers. Second primary cancers are often detected at an early stage, where radical treatment can be performed for both primary and secondary tumour. However, treatment of such complicated clinical cases as synchronous cancers should be carried out by multidisciplinary teams.
Keywords
cervical cancer, synchronous cancer, second primary cancer, PET-CT
About this articleTitle
Strategy and early results of treatment of advanced cervical cancer patients with synchronous cancers observed in PET-CT imaging
Journal
Issue
Article type
Research paper
Pages
475-480
Published online
2017-09-29
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1359
Article views/downloads
1343
DOI
Pubmed
Bibliographic record
Ginekol Pol 2017;88(9):475-480.
Keywords
cervical cancer
synchronous cancer
second primary cancer
PET-CT
Authors
Michał Płachta
Witold Cholewiński
Ewa Burchardt
Paulina Cegła
Bartosz Urbański
Żaneta Wareńczak-Florczak
Andrzej Roszak
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