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Perspectives for the pharmacological treatment of overactive bladder syndrome
Affiliations- Second Department of Gynecology, Medical University of Lublin,, Jaczewskiego 8, PL 20-090 Lublin, Poland, 20-090 Lublin, Poland
- Department of Obstetrics and Gynecology, Fryderyk Chopin University Hospital No 1, Faculty of Medicine, Rzeszow University, Chopina 2, PL 35-055 Rzeszów, Poland, 35-055 Rzeszów, Poland
- Department of Operative Gynecology and Gynecologic Oncology, Ist Department of Gynecology and Obstetrics, Medical University of Łódź, Wileńska 37, 94-029 Łódź, Poland, 94-029 Łódź, Poland
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Abstract
It has been found that antimuscarinic drugs, viewed as the “gold standard” in overactive bladder syndrome (OAB) treatment, have an unsatisfactory tolerance profile and limited clinical effectiveness. This fact has given a clear impetus to search for new options in OAB pharmacotherapy. The conducted pre-clinical trials have led to the development of new solutions for the treatment of OAB, which stand a good chance of being applied in clinical practice. The said compounds are characterised by higher receptor and organ specificity than currently used medications.
Abstract
It has been found that antimuscarinic drugs, viewed as the “gold standard” in overactive bladder syndrome (OAB) treatment, have an unsatisfactory tolerance profile and limited clinical effectiveness. This fact has given a clear impetus to search for new options in OAB pharmacotherapy. The conducted pre-clinical trials have led to the development of new solutions for the treatment of OAB, which stand a good chance of being applied in clinical practice. The said compounds are characterised by higher receptor and organ specificity than currently used medications.
Keywords
overactive bladder syndrome, pharmacotherapy, detrusor overactivity
About this articleTitle
Perspectives for the pharmacological treatment of overactive bladder syndrome
Journal
Issue
Article type
Review paper
Pages
504-508
Published online
2017-09-29
Page views
1457
Article views/downloads
1435
DOI
10.5603/GP.a2017.0092
Pubmed
Bibliographic record
Ginekol Pol 2017;88(9):504-508.
Keywords
overactive bladder syndrome
pharmacotherapy
detrusor overactivity
Authors
Andrzej Wróbel
Tomasz Kluz
Grzegorz Surkont
Edyta Wlaźlak
Paweł Miotła
Katarzyna Skorupska
Tomasz Rechberger
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